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MTPN antibody (Middle Region)

MTPN Reactivity: Human, Mouse, Rat, Dog, Cow, Rabbit, Guinea Pig, Zebrafish (Danio rerio), Horse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2785128
  • Target See all MTPN Antibodies
    MTPN (Myotrophin (MTPN))
    Binding Specificity
    • 15
    • 3
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivity
    • 24
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog, Cow, Rabbit, Guinea Pig, Zebrafish (Danio rerio), Horse
    Host
    • 21
    • 4
    Rabbit
    Clonality
    • 23
    • 2
    Polyclonal
    Conjugate
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MTPN antibody is un-conjugated
    Application
    • 25
    • 13
    • 13
    • 8
    • 5
    • 3
    • 3
    • 2
    • 2
    Western Blotting (WB)
    Sequence
    GRKPLHYAAD CGQLEILEFL LLKGADINAP DKHHITPLLS AVYEGHVSCV
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
    Characteristics
    This is a rabbit polyclonal antibody against MTPN. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human MTPN
    Top Product
    Discover our top product MTPN Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 118 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Nghiem, Hoffman, Mittal, Brown, Schatzberg, Ghimbovschi, Wang, Kornegay: "Sparing of the dystrophin-deficient cranial sartorius muscle is associated with classical and novel hypertrophy pathways in GRMD dogs." in: The American journal of pathology, Vol. 183, Issue 5, pp. 1411-24, (2013) (PubMed).

  • Target
    MTPN (Myotrophin (MTPN))
    Alternative Name
    MTPN (MTPN Products)
    Synonyms
    MGC76285 antibody, GCDP antibody, V-1 antibody, Gcdp antibody, wu:fa10f07 antibody, zgc:64078 antibody, 5033418D15Rik antibody, V1 antibody, myotrophin antibody, myotrophin S homeolog antibody, mtpn antibody, MTPN antibody, Mtpn antibody, mtpn.S antibody
    Background
    MTPN has a potential role in cerebellar morphogenesis. MTPN may function in differentiation of cerebellar neurons, particularly of granule cells. MTPN seems to be associated with cardiac hypertrophy.The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease.
    Alias Symbols: FLJ31098, GCDP, V-1
    Protein Interaction Partner: RBBP4, RAB1A, PTPN11, OXCT1, MTAP, PDIA3, ATP6V1A, UBC, NPLOC4, ELAVL1, MAPK1, CAPZB, RELA, NFKB1, REL, DSTYK,
    Protein Size: 118
    Molecular Weight
    13 kDa
    Gene ID
    136319
    NCBI Accession
    NM_145808, NP_665807
    UniProt
    P58546
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