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AGO2 antibody (AA 1-377)

AGO2 Reactivity: Human WB, ELISA, IF, IHC (p), RNAi Host: Mouse Monoclonal 2E12-1C9 unconjugated
Catalog No. ABIN565346
  • Target See all AGO2 Antibodies
    AGO2 (Argonaute 2 (AGO2))
    Binding Specificity
    • 8
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-377
    Reactivity
    • 45
    • 22
    • 14
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 44
    • 3
    Mouse
    Clonality
    • 32
    • 15
    Monoclonal
    Conjugate
    • 24
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This AGO2 antibody is un-conjugated
    Application
    • 28
    • 17
    • 14
    • 9
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), RNA Interference (RNAi)
    Purpose
    Mouse monoclonal antibody raised against a full length recombinant EIF2C2.
    Sequence
    MPIQGQPCFC KYAQGADSVE PMFRHLKNTY AGLQLVVVIL PGKTPVYAEV KRVGDTVLGM ATQCVQMKNV QRTTPQTLSN LCLKINVKLG GVNNILLPQG RPPVFQQPVI FLGADVTHPP AGDGKKPSIA AVVGSMDAHP NRYCATVRVQ QHRQEIIQDL AAMVRELLIQ FYKSTRFKPT RIIFYRDGVS EGQFQQVLHH ELLAIREACI KLEKDYQPGI TFIVVQKRHH TRLFCTDKNE RVGKSGNIPA GTTVDTKITH PTEFDFYLCS HAGIQGTSRP SHYHVLWDDN RFSSDELQIL TYQLCHTYVR CTRSVSIPAP AYYAHLVAFR ARYHLVDKEH DSAEGSHTSG QSNGRDHQAL AKAVQVHQDT LRTMYFA
    Cross-Reactivity
    Human
    Characteristics
    Antibody Reactive Against Recombinant Protein.
    Immunogen
    EIF2C2 (AAH07633.1, 483 a.a. ~ 859 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
    Clone
    2E12-1C9
    Isotype
    IgG1
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Buffer
    In 1x PBS, pH 7.4
    Handling Advice
    Aliquot to avoid repeated freezing and thawing.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Mantel, Hjelmqvist, Walch, Kharoubi-Hess, Nilsson, Ravel, Ribeiro, Grüring, Ma, Padmanabhan, Trachtenberg, Ankarklev, Brancucci, Huttenhower, Duraisingh, Ghiran, Kuo, Filgueira, Martinelli, Marti: "Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria." in: Nature communications, Vol. 7, pp. 12727, (2016) (PubMed).

    Wang, Ye, Wei, Han, He, Chen, Chen: "LncRNAs H19 and HULC, activated by oxidative stress, promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner." in: Journal of hematology & oncology, Vol. 9, Issue 1, pp. 117, (2016) (PubMed).

    Xiao, Wang, Ni, Li, Zhang, Liu, Pu, Xu, Gao, Zhao, Mu, Wang, Sun, Du, Xu, Zhang, Hiscox, Goodfellow, Zhou: "MicroRNA miR-24-3p Promotes Porcine Reproductive and Respiratory Syndrome Virus Replication through Suppression of Heme Oxygenase-1 Expression." in: Journal of virology, Vol. 89, Issue 8, pp. 4494-503, (2015) (PubMed).

    Zhang, Guo, Gao, Huang, Li, Jia, Liu, Feng: "MicroRNA-23 inhibits PRRSV replication by directly targeting PRRSV RNA and possibly by upregulating type I interferons." in: Virology, Vol. 450-451, pp. 182-95, (2014) (PubMed).

    Nakanishi, Taccioli, Palatini, Fernandez-Cymering, Cui, Kim, Volinia, Croce: "Loss of miR-125b-1 contributes to head and neck cancer development by dysregulating TACSTD2 and MAPK pathway." in: Oncogene, Vol. 33, Issue 6, pp. 702-12, (2014) (PubMed).

    Sasaki, Gross, Xing, Goshima, Bassell: "Identification of axon-enriched microRNAs localized to growth cones of cortical neurons." in: Developmental neurobiology, Vol. 74, Issue 3, pp. 397-406, (2014) (PubMed).

    Pai, Siripornmongcolchai, Berentsen, Pakzad, Vieuille, Pallesen, Pajak, Simpson, Armstrong, Wibrand, Bramham: "NMDA receptor-dependent regulation of miRNA expression and association with Argonaute during LTP in vivo." in: Frontiers in cellular neuroscience, Vol. 7, pp. 285, (2014) (PubMed).

    Le Guillou, Marthey, Laloë, Laubier, Mobuchon, Leroux, Le Provost: "Characterisation and comparison of lactating mouse and bovine mammary gland miRNomes." in: PLoS ONE, Vol. 9, Issue 3, pp. e91938, (2014) (PubMed).

    Zhang, Zuo, Yang, Li, Xue, Zhou, Huang, Zhao, Zhou, Yan, Zhang, Guo, Sun, Guo, Zhang, Fu: "MicroRNA directly enhances mitochondrial translation during muscle differentiation." in: Cell, Vol. 158, Issue 3, pp. 607-19, (2014) (PubMed).

    Kamel, Segerman, Punga, Akusjärvi: "Small RNA sequence analysis of adenovirus VA RNA-derived miRNAs reveals an unexpected serotype-specific difference in structure and abundance." in: PLoS ONE, Vol. 9, Issue 8, pp. e105746, (2014) (PubMed).

    Llobet-Navas, Rodriguez-Barrueco, de la Iglesia-Vicente, Olivan, Castro, Saucedo-Cuevas, Marshall, Putcha, Castillo-Martin, Bardot, Ezhkova, Iavarone, Cordon-Cardo, Silva: "The microRNA 424/503 cluster reduces CDC25A expression during cell cycle arrest imposed by transforming growth factor ? in mammary epithelial cells." in: Molecular and cellular biology, Vol. 34, Issue 23, pp. 4216-31, (2014) (PubMed).

    Xue, Ouyang, Huang, Zhou, Ouyang, Li, Wang, Wu, Wei, Bi, Jiang, Cai, Sun, Zhang, Zhang, Chen, Fu: "Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits." in: Cell, Vol. 152, Issue 1-2, pp. 82-96, (2013) (PubMed).

    Wei, Nazari-Jahantigh, Chan, Zhu, Heyll, Corbalán-Campos, Hartmann, Thiemann, Weber, Schober: "The microRNA-342-5p fosters inflammatory macrophage activation through an Akt1- and microRNA-155-dependent pathway during atherosclerosis." in: Circulation, Vol. 127, Issue 15, pp. 1609-19, (2013) (PubMed).

    Laffont, Corduan, Plé, Duchez, Cloutier, Boilard, Provost: "Activated platelets can deliver mRNA regulatory Ago2•microRNA complexes to endothelial cells via microparticles." in: Blood, Vol. 122, Issue 2, pp. 253-61, (2013) (PubMed).

    Zheng, Zhang, Zhang, Wang, Ye, Xi, Du, Liang: "Single modification at position 14 of siRNA strand abolishes its gene-silencing activity by decreasing both RISC loading and target degradation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 27, Issue 10, pp. 4017-26, (2013) (PubMed).

    Curtale, Mirolo, Renzi, Rossato, Bazzoni, Locati: "Negative regulation of Toll-like receptor 4 signaling by IL-10-dependent microRNA-146b." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 28, pp. 11499-504, (2013) (PubMed).

    Karginov, Hannon: "Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates." in: Genes & development, Vol. 27, Issue 14, pp. 1624-32, (2013) (PubMed).

    Fan, Krutilina, Sun, Sethuraman, Yang, Wu, Yue, Pfeffer: "Comprehensive analysis of microRNA (miRNA) targets in breast cancer cells." in: The Journal of biological chemistry, Vol. 288, Issue 38, pp. 27480-93, (2013) (PubMed).

    Martinez-Sanchez, Dudek, Murphy: "Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145)." in: The Journal of biological chemistry, Vol. 287, Issue 2, pp. 916-24, (2012) (PubMed).

    Chiang, Sung, Rice: "Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes." in: Journal of virology, Vol. 86, Issue 6, pp. 3244-52, (2012) (PubMed).

  • Target
    AGO2 (Argonaute 2 (AGO2))
    Alternative Name
    EIF2C2 (AGO2 Products)
    Synonyms
    EIF2C2 antibody, T19E23.7 antibody, T19E23_7 antibody, argonaute 2 antibody, Q10 antibody, Eif2c2 antibody, Argonaute2 antibody, eif2c1 antibody, eif2c2 antibody, 1110029L17Rik antibody, 2310051F07Rik antibody, AI225898 antibody, AL022874 antibody, AW546247 antibody, ENSMUSG00000072493 antibody, Gerp95 antibody, Gm10365 antibody, mKIAA4215 antibody, AGO2 antibody, AG02 antibody, AGO 2 antibody, Ago-2 antibody, Ago2 antibody, CG13452 antibody, CG7439 antibody, Dm Ago2 antibody, Dmel\\CG7439 antibody, ago antibody, ago-2 antibody, ago2 antibody, dAGO2 antibody, dAgo2 antibody, eIF2C2 antibody, argonaute 2, RISC catalytic component antibody, Argonaute family protein antibody, argonaute 2, RISC catalytic component L homeolog antibody, argonaute RISC catalytic subunit 2 antibody, argonaute RISC catalytic component 2 antibody, Argonaute 2 antibody, AGO2 antibody, Ago2 antibody, ago2.L antibody, ago2 antibody
    Background
    Full Gene Name: eukaryotic translation initiation factor 2C, 2
    Synonyms: AGO2,MGC3183,Q10
    Gene ID
    27161
    Pathways
    Fc-epsilon Receptor Signaling Pathway, Regulatory RNA Pathways, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Ribonucleoprotein Complex Subunit Organization
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