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DDX58 antibody (C-Term)

DDX58 Reactivity: Human, Mouse WB Host: Rabbit Polyclonal RB8008 unconjugated
Catalog No. ABIN388602
  • Target See all DDX58 Antibodies
    DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))
    Binding Specificity
    • 15
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 894-925, C-Term
    Reactivity
    • 63
    • 40
    • 17
    • 2
    • 1
    Human, Mouse
    Host
    • 58
    • 8
    • 1
    Rabbit
    Clonality
    • 60
    • 7
    Polyclonal
    Conjugate
    • 34
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This DDX58 antibody is un-conjugated
    Application
    • 60
    • 19
    • 14
    • 14
    • 14
    • 11
    • 7
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This RIG-I antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 894-925 amino acids from the C-terminal region of human RIG-I.
    Clone
    RB8008
    Isotype
    Ig Fraction
    Top Product
    Discover our top product DDX58 Primary Antibody
  • Application Notes
    WB: 1:1000. WB: 1:2000. WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Munday, Howell, Barr, Hiscox: "Proteomic analysis of mitochondria in respiratory epithelial cells infected with human respiratory syncytial virus and functional implications for virus and cell biology." in: The Journal of pharmacy and pharmacology, Vol. 67, Issue 3, pp. 300-18, (2015) (PubMed).

    Huang, Kolokoltsova, Yun, Seregin, Ronca, Koma, Paessler: "Highly Pathogenic New World and Old World Human Arenaviruses Induce Distinct Interferon Responses in Human Cells." in: Journal of virology, Vol. 89, Issue 14, pp. 7079-88, (2015) (PubMed).

    Crill, Furr-Rogers, Marriott: "RIG-I is required for VSV-induced cytokine production by murine glia and acts in combination with DAI to initiate responses to HSV-1." in: Glia, (2015) (PubMed).

    Feng, Langereis, Lork, Nguyen, Hato, Lanke, Emdad, Bhoopathi, Fisher, Lloyd, van Kuppeveld: "Enterovirus 2Apro targets MDA5 and MAVS in infected cells." in: Journal of virology, Vol. 88, Issue 6, pp. 3369-78, (2014) (PubMed).

    Huang, Kolokoltsova, Yun, Seregin, Poussard, Walker, Brasier, Zhao, Tian, de la Torre, Paessler: "Junín virus infection activates the type I interferon pathway in a RIG-I-dependent manner." in: PLoS neglected tropical diseases, Vol. 6, Issue 5, pp. e1659, (2012) (PubMed).

    Furr, Moerdyk-Schauwecker, Grdzelishvili, Marriott: "RIG-I mediates nonsegmented negative-sense RNA virus-induced inflammatory immune responses of primary human astrocytes." in: Glia, Vol. 58, Issue 13, pp. 1620-9, (2010) (PubMed).

    Barral, Sarkar, Fisher, Racaniello: "RIG-I is cleaved during picornavirus infection." in: Virology, Vol. 391, Issue 2, pp. 171-6, (2009) (PubMed).

    Bao, Liu, Shan, Li, Garofalo, Casola: "Human metapneumovirus glycoprotein G inhibits innate immune responses." in: PLoS pathogens, Vol. 4, Issue 5, pp. e1000077, (2008) (PubMed).

    Liao, Bao, Liu, Lai, Li, Garofalo, Casola: "Role of retinoic acid inducible gene-I in human metapneumovirus-induced cellular signalling." in: The Journal of general virology, Vol. 89, Issue Pt 8, pp. 1978-86, (2008) (PubMed).

  • Target
    DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))
    Alternative Name
    RIG-I (DDX58 Products)
    Synonyms
    RIG-I antibody, RIGI antibody, RLR-1 antibody, 6430573D20Rik antibody, C330021E21 antibody, RHIV-1 antibody, RIG-1 antibody, DExD/H-box helicase 58 antibody, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 antibody, DEXD/H-box helicase 58 antibody, DDX58 antibody, Ddx58 antibody
    Background
    DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. RIG-I contains RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, RIG-I triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). This protein is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV.
    Molecular Weight
    106600
    Gene ID
    23586
    NCBI Accession
    NP_055129
    UniProt
    O95786
    Pathways
    Activation of Innate immune Response, Hepatitis C
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