COX6A2 antibody (AA 37-66)

Catalog No. ABIN653569

Product Details anti-COX6A2 Antibody

Target: COX6A2 (Cytochrome C Oxidase Subunit VIa Polypeptide 2 (COX6A2))

Binding Specificity: AA 37-66

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COX6A2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This COX6A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids from the Central region of human COX6A2.

Clone: RB23260

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-COX6A2 antibody (ABIN653569)

Boczonadi, Giunta, Lane, Tulinius, Schara, Horvath: "Investigating the role of the physiological isoform switch of cytochrome c oxidase subunits in reversible mitochondrial disease." in: The international journal of biochemistry & cell biology, (2015) (PubMed).

Target Details for COX6A2

Target: COX6A2 (Cytochrome C Oxidase Subunit VIa Polypeptide 2 (COX6A2))

Alternative Name: COX6A2 (COX6A2 Products)

Synonyms: COX6AH antibody, COXVIAH antibody, CoxVIaH antibody, VIaH antibody, cytochrome c oxidase subunit 6A2 antibody, cytochrome c oxidase subunit VIa polypeptide 2 antibody, COX6A2 antibody, Cox6a2 antibody

Background: Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (heart/muscle isoform) of subunit VIa, and polypeptide 2 is present only in striated muscles. Polypeptide 1 (liver isoform) of subunit VIa is encoded by a different gene, and is found in all non-muscle tissues. These two polypeptides share 66 % amino acid sequence identity.

Molecular Weight: 10815

Gene ID: 1339

NCBI Accession: NP_005196

UniProt: Q02221