ZP4 antibody (C-Term)

Catalog No. ABIN656652

Product Details anti-ZP4 Antibody

Target: ZP4 (Zona Pellucida Glycoprotein 4 (ZP4))

Binding Specificity: AA 445-474, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZP4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ZP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 445-474 amino acids from the C-terminal region of human ZP4.

Clone: RB32332

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:2000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: ZP4 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Expiry Date: 6 months

References for anti-ZP4 antibody (ABIN656652)

Mask, Schoenecker, Kane, Ransom, Bruemmer: "Serum antibody immunoreactivity to equine zona protein after SpayVac vaccination." in: Theriogenology, Vol. 84, Issue 2, pp. 261-7, (2015) (PubMed).

Target Details for ZP4

Target: ZP4 (Zona Pellucida Glycoprotein 4 (ZP4))

Alternative Name: ZP4 (ZP4 Products)

Synonyms: ZPB antibody, xlZPB antibody, lzpb-a antibody, MGC154827 antibody, zbp antibody, zp1 antibody, ZBP antibody, TAC4 antibody, MGC154888 antibody, ZP1 antibody, Zp-4 antibody, ZP3-ALPHA antibody, ZP antibody, Zp-X antibody, zona pellucida glycoprotein 4 S homeolog antibody, zona pellucida glycoprotein 4 antibody, zona pellucida glycoprotein 4 L homeolog antibody, zp4.S antibody, zp4 antibody, ZP4 antibody, zp4.L antibody, Zp4 antibody

Background: The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4.

Molecular Weight: 59400

Gene ID: 57829

NCBI Accession: NP_067009

UniProt: Q12836