CAMKK2 antibody (C-Term)

Catalog No. ABIN1882069

Product Details anti-CAMKK2 Antibody

Target: CAMKK2 (Calcium/calmodulin-Dependent Protein Kinase Kinase 2, beta (CAMKK2))

Binding Specificity: AA 483-512, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAMKK2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This CAMKK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 483-512 amino acids from the C-terminal region of human CAMKK2.

Clone: RB12560

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CAMKK2 antibody (ABIN1882069)

Wang, Zhang, Liang, Zhang, Xu, Zhang, Fuji, Mu, Li, Jiang, Ju, Wang: "Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin." in: Scientific reports, Vol. 5, pp. 12012, (2015) (PubMed).

Goravanahally, Salem, Yao, Inskeep, Flores: "Differential gene expression in the bovine corpus luteum during transition from early phase to midphase and its potential role in acquisition of luteolytic sensitivity to prostaglandin F2 alpha." in: Biology of reproduction, Vol. 80, Issue 5, pp. 980-8, (2009) (PubMed).

Hsu, Chen, Lee, Chi, Cheng, Chen: "Human Ca2+/calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity." in: The Journal of biological chemistry, Vol. 276, Issue 33, pp. 31113-23, (2001) (PubMed).

Hsu, Tsou, Chi, Lee, Chen: "Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase." in: Journal of biomedical science, Vol. 5, Issue 2, pp. 141-9, (1998) (PubMed).

Anderson, Means, Huang, Kemp, Goldstein, Selbert, Edelman, Fremeau, Means: "Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta." in: The Journal of biological chemistry, Vol. 273, Issue 48, pp. 31880-9, (1998) (PubMed).

Target Details for CAMKK2

Target: CAMKK2 (Calcium/calmodulin-Dependent Protein Kinase Kinase 2, beta (CAMKK2))

Alternative Name: CAMKK2 (CAMKK2 Products)

Background: CAMKK2 belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. CAMKK2 appears to be involved in hippocampal activation of CREB1.

Molecular Weight: 64746

NCBI Accession: NP_001257414, NP_001257415, NP_006540, NP_705719, NP_705720, NP_757363, NP_757364, NP_757365, NP_757380

UniProt: Q96RR4

Pathways: AMPK Signaling