C1S antibody

Catalog No. ABIN1944822

Product Details anti-C1S Antibody

Target: C1S (Complement Component 1, S Subcomponent (C1S))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C1S antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Isotype: IgG1

Application Details

Application Notes: WB: 1:500-1:1000. IHC: 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Storage: 4 °C,-20 °C

References for anti-C1S antibody (ABIN1944822)

Endo, Takahashi, Nakao, Saiga, Sekine, Matsushita, Nonaka, Fujita: "Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 161, Issue 9, pp. 4924-30, (1998) (PubMed).

Mackinnon, Carter, Smyth, Dunbar, Fothergill: "Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence." in: European journal of biochemistry / FEBS, Vol. 169, Issue 3, pp. 547-53, (1988) (PubMed).

Kusumoto, Hirosawa, Salier, Hagen, Kurachi: "Human genes for complement components C1r and C1s in a close tail-to-tail arrangement." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, Issue 19, pp. 7307-11, (1988) (PubMed).

Tosi, Duponchel, Meo, Julier: "Complete cDNA sequence of human complement Cls and close physical linkage of the homologous genes Cls and Clr." in: Biochemistry, Vol. 26, Issue 26, pp. 8516-24, (1988) (PubMed).

Target Details for C1S

Target: C1S (Complement Component 1, S Subcomponent (C1S))

Alternative Name: C1S (C1S Products)

Synonyms: AA959438 antibody, AI255193 antibody, AI327365 antibody, C1sa antibody, r-gsp antibody, C1S antibody, complement C1s antibody, complement component 1, s subcomponent 1 antibody, complement component 1, s subcomponent antibody, complement component 1, s subcomponent L homeolog antibody, complement C1s subcomponent antibody, C1S antibody, C1s1 antibody, C1s antibody, c1s antibody, c1s.L antibody, LOC100558615 antibody

Background: C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.

Molecular Weight: 76684 Da

Gene ID: 716

UniProt: P09871

Pathways: Complement System