Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Predicted Reactivity
X, Rat
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This SDHA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 577-605 amino acids from the C-terminal region of human SDHA.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Parfait, Chretien, Rötig, Marsac, Munnich, Rustin: "Compound heterozygous mutations in the flavoprotein gene of the respiratory chain complex II in a patient with Leigh syndrome." in: Human genetics, Vol. 106, Issue 2, pp. 236-43, (2000) (PubMed).
Hirawake, Wang, Kuramochi, Kojima, Kita: "Human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of the flavoprotein (Fp) subunit of liver mitochondria." in: Journal of biochemistry, Vol. 116, Issue 1, pp. 221-7, (1995) (PubMed).
Morris, Farnsworth, Ackrell, Turnbull, Birch-Machin: "The cDNA sequence of the flavoprotein subunit of human heart succinate dehydrogenase." in: Biochimica et biophysica acta, Vol. 1185, Issue 1, pp. 125-8, (1994) (PubMed).
Target
SDHA
(Succinate Dehydrogenase Complex, Subunit A, Flavoprotein (Fp) (SDHA))
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor.