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GRK4 antibody (C-Term)

GRK4 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB0901 unconjugated
Catalog No. ABIN1882085
  • Target See all GRK4 Antibodies
    GRK4 (G Protein-Coupled Receptor Kinase 4 (GRK4))
    Binding Specificity
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 549-577, C-Term
    Reactivity
    • 27
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 21
    • 7
    Rabbit
    Clonality
    • 22
    • 6
    Polyclonal
    Conjugate
    • 18
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GRK4 antibody is un-conjugated
    Application
    • 17
    • 12
    • 6
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This GRK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 549-577 amino acids from the C-terminal region of human GRK4.
    Clone
    RB0901
    Isotype
    Ig Fraction
    Top Product
    Discover our top product GRK4 Primary Antibody
  • Application Notes
    WB: 1:1000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Villar, Jones, Armando, Palmes-Saloma, Yu, Pascua, Keever, Arnaldo, Wang, Luo, Felder, Jose: "G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor." in: The Journal of biological chemistry, Vol. 284, Issue 32, pp. 21425-34, (2009) (PubMed).

    Perroy, Adam, Qanbar, Chénier, Bouvier: "Phosphorylation-independent desensitization of GABA(B) receptor by GRK4." in: The EMBO journal, Vol. 22, Issue 15, pp. 3816-24, (2003) (PubMed).

    Watanabe, Xu, Bengra, Jose, Felder: "Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4." in: Kidney international, Vol. 62, Issue 3, pp. 790-8, (2002) (PubMed).

    Sallese, Mariggiò, Collodel, Moretti, Piomboni, Baccetti, De Blasi: "G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells." in: The Journal of biological chemistry, Vol. 272, Issue 15, pp. 10188-95, (1997) (PubMed).

    Premont, Macrae, Stoffel, Chung, Pitcher, Ambrose, Inglese, MacDonald, Lefkowitz: "Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants." in: The Journal of biological chemistry, Vol. 271, Issue 11, pp. 6403-10, (1996) (PubMed).

    Sallese, Lombardi, De Blasi: "Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning." in: Biochemical and biophysical research communications, Vol. 199, Issue 2, pp. 848-54, (1994) (PubMed).

  • Target
    GRK4 (G Protein-Coupled Receptor Kinase 4 (GRK4))
    Alternative Name
    GRK4 (GRK4 Products)
    Synonyms
    GPRK2L antibody, GPRK4 antibody, GRK4a antibody, IT11 antibody, A830025H08Rik antibody, GRK antibody, Gprk2l antibody, Gprk4 antibody, AMPK antibody, AMPKalpha antibody, CG3051 antibody, DmAMPK alpha antibody, Dmel\\CG3051 antibody, EG:132E8.2 antibody, FBgn0023169 antibody, Gprk-4 antibody, ampk antibody, ampkalpha antibody, dAMPKa antibody, dAMPKalpha antibody, snf1a antibody, gprk4 antibody, gprk4-a antibody, grk4 antibody, GRK4 antibody, gprk4-b antibody, zgc:153020 antibody, gprk2l antibody, grk4a antibody, it11 antibody, G protein-coupled receptor kinase 4 antibody, AMP-activated protein kinase alpha subunit antibody, G protein-coupled receptor kinase 4 L homeolog antibody, G protein-coupled receptor kinase 4 S homeolog antibody, GRK4 antibody, Grk4 antibody, AMPKalpha antibody, grk4.L antibody, grk4.S antibody, grk4 antibody, LOC100540688 antibody
    Background
    Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).
    Molecular Weight
    66583
    NCBI Accession
    NP_001004056, NP_001004057, NP_892027
    UniProt
    P32298
    Pathways
    Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling
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