Neuregulin 2 antibody (C-Term)

Catalog No. ABIN1882105

Product Details anti-Neuregulin 2 Antibody

Target: Neuregulin 2 (NRG2)

Binding Specificity: AA 358-389, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neuregulin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This NRG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 358-389 amino acids from the C-terminal region of human NRG2.

Clone: RB1278

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-Neuregulin 2 antibody (ABIN1882105)

Yamada, Ichino, Nishii, Sawada, Higashiyama, Ishiguro, Nagatsu: "Characterization of the human NTAK gene structure and distribution of the isoforms for rat NTAK mRNA." in: Gene, Vol. 255, Issue 1, pp. 15-24, (2000) (PubMed).

Ring, Chang, Guilbot, Brice, LeGuern, Francke: "The human neuregulin-2 (NRG2) gene: cloning, mapping and evaluation as a candidate for the autosomal recessive form of Charcot-Marie-Tooth disease linked to 5q." in: Human genetics, Vol. 104, Issue 4, pp. 326-32, (1999) (PubMed).

Higashiyama, Horikawa, Yamada, Ichino, Nakano, Nakagawa, Miyagawa, Matsushita, Nagatsu, Taniguchi, Ishiguro: "A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4." in: Journal of biochemistry, Vol. 122, Issue 3, pp. 675-80, (1998) (PubMed).

Carraway, Weber, Unger, Ledesma, Yu, Gassmann, Lai: "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases." in: Nature, Vol. 387, Issue 6632, pp. 512-6, (1997) (PubMed).

Busfield, Michnick, Chickering, Revett, Ma, Woolf, Comrack, Dussault, Woolf, Goodearl, Gearing: "Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus." in: Molecular and cellular biology, Vol. 17, Issue 7, pp. 4007-14, (1997) (PubMed).

Target Details for Neuregulin 2

Target: Neuregulin 2 (NRG2)

Alternative Name: NRG2 (NRG2 Products)

Background: Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the Erbb family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. There are six NRG2 alternatively spliced transcripts which are variable between the epidermal growth factor-like (EGF-like) and the transmembrane domains. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease.

Molecular Weight: 91679

NCBI Accession: NP_001171864, NP_004874, NP_053584, NP_053585, NP_053586

UniProt: O14511

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway