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IL-6 antibody

IL6 Reactivity: Human ELISA, FACS, Func, ELISpot Host: Mouse Monoclonal B-E8 unconjugated
Catalog No. ABIN1383944
  • Target See all IL-6 (IL6) Antibodies
    IL-6 (IL6) (Interleukin 6 (IL6))
    Reactivity
    • 169
    • 129
    • 69
    • 28
    • 22
    • 21
    • 15
    • 13
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    Human
    Host
    • 195
    • 81
    • 54
    • 11
    • 4
    • 3
    • 2
    Mouse
    Clonality
    • 213
    • 134
    • 1
    Monoclonal
    Conjugate
    • 189
    • 57
    • 26
    • 10
    • 9
    • 8
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL-6 antibody is un-conjugated
    Application
    • 262
    • 131
    • 104
    • 52
    • 49
    • 46
    • 41
    • 41
    • 38
    • 30
    • 25
    • 25
    • 22
    • 19
    • 15
    • 8
    • 7
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA, Flow Cytometry (FACS), Functional Studies (Func), ELISpot
    Specificity
    Recognises both natural and recombinant human IL-6
    Purification
    Ion exchange chromatography
    Sterility
    0.22 μm filtered
    Immunogen
    Recombinant human IL-6,Myeloma X63/AG.8653 x Balb/c spleen cells
    Clone
    B-E8
    Isotype
    IgG1 kappa
    Biological Activity Comment
    Inhibits IL-6 induced proliferation on XG1 Cell line
    Top Product
    Discover our top product IL6 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free
    Preservative
    Without preservative
    Storage
    4 °C
    Storage Comment
    Stable at +2-8°C for 12 months. For longer storage freeze aliquots.
  • Sprynski, Hose, Caillot, Réme, Shaughnessy, Barlogie, Seckinger, Moreaux, Hundemer, Jourdan, Meissner, Jauch, Mahtouk, Kassambara, Bertsch, Rossi, Goldschmidt, Klein: "The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor." in: Blood, Vol. 113, Issue 19, pp. 4614-26, (2009) (PubMed).

    Adam, Rabe, Suthaus, Grötzinger, Rose-John, Scheller: "Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor." in: Journal of virology, Vol. 83, Issue 10, pp. 5117-26, (2009) (PubMed).

    Moreau, Garban, Attal, Michallet, Marit, Hulin, Benboubker, Doyen, Mohty, Yakoub-Agha, Leyvraz, Casassus, Avet-Loiseau, Garderet, Mathiot, Harousseau: "Long-term follow-up results of IFM99-03 and IFM99-04 trials comparing nonmyeloablative allotransplantation with autologous transplantation in high-risk de novo multiple myeloma." in: Blood, Vol. 112, Issue 9, pp. 3914-5, (2008) (PubMed).

    Garban, Attal, Michallet, Hulin, Bourhis, Yakoub-Agha, Lamy, Marit, Maloisel, Berthou, Dib, Caillot, Deprijck, Ketterer, Harousseau, Sotto, Moreau: "Prospective comparison of autologous stem cell transplantation followed by dose-reduced allograft (IFM99-03 trial) with tandem autologous stem cell transplantation (IFM99-04 trial) in high-risk de novo multiple myeloma." in: Blood, Vol. 107, Issue 9, pp. 3474-80, (2006) (PubMed).

    Moreau, Hullin, Garban, Yakoub-Agha, Benboubker, Attal, Marit, Fuzibet, Doyen, Voillat, Berthou, Ketterer, Casassus, Monconduit, Michallet, Najman, Sotto, Bataille, Harousseau: "Tandem autologous stem cell transplantation in high-risk de novo multiple myeloma: final results of the prospective and randomized IFM 99-04 protocol." in: Blood, Vol. 107, Issue 1, pp. 397-403, (2005) (PubMed).

    Song, Torphy, Griswold, Shealy: "Coming of age: anti-cytokine therapies." in: Molecular interventions, Vol. 2, Issue 1, pp. 36-46, (2004) (PubMed).

    Moreaux, Legouffe, Jourdan, Quittet, Rème, Lugagne, Moine, Rossi, Klein, Tarte: "BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone." in: Blood, Vol. 103, Issue 8, pp. 3148-57, (2004) (PubMed).

    Derhaschnig, Bergmair, Marsik, Schlifke, Wijdenes, Jilma: "Effect of interleukin-6 blockade on tissue factor-induced coagulation in human endotoxemia." in: Critical care medicine, Vol. 32, Issue 5, pp. 1136-40, (2004) (PubMed).

    Smith, Barg, Weedon, Papengelis, Smeets, Tak, Kraan, Coleman, Ahern: "Microarchitecture and protective mechanisms in synovial tissue from clinically and arthroscopically normal knee joints." in: Annals of the rheumatic diseases, Vol. 62, Issue 4, pp. 303-7, (2003) (PubMed).

    Ancey, Menet, Corbi, Fredj, Garcia, Rücker-Martin, Bescond, Morel, Wijdenes, Lecron, Potreau: "Human cardiomyocyte hypertrophy induced in vitro by gp130 stimulation." in: Cardiovascular research, Vol. 59, Issue 1, pp. 78-85, (2003) (PubMed).

    Choy: "Interleukin 6 receptor as a target for the treatment of rheumatoid arthritis." in: Annals of the rheumatic diseases, Vol. 62 Suppl 2, pp. ii68-9, (2003) (PubMed).

    Derenne, Monia, Dean, Taylor, Rapp, Harousseau, Bataille, Amiot: "Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells." in: Blood, Vol. 100, Issue 1, pp. 194-9, (2002) (PubMed).

    Delneste, Charbonnier, Herbault, Magistrelli, Caron, Bonnefoy, Jeannin: "Interferon-gamma switches monocyte differentiation from dendritic cells to macrophages." in: Blood, Vol. 101, Issue 1, pp. 143-50, (2002) (PubMed).

    Leblond, Dhedin, Mamzer Bruneel, Choquet, Hermine, Porcher, Nguyen Quoc, Davi, Charlotte, Dorent, Barrou, Vernant, Raphael, Levy: "Identification of prognostic factors in 61 patients with posttransplantation lymphoproliferative disorders." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 19, Issue 3, pp. 772-8, (2001) (PubMed).

    Jego, Bataille, Pellat-Deceunynck: "Interleukin-6 is a growth factor for nonmalignant human plasmablasts." in: Blood, Vol. 97, Issue 6, pp. 1817-22, (2001) (PubMed).

    Menetrier-Caux, Thomachot, Alberti, Montmain, Blay: "IL-4 prevents the blockade of dendritic cell differentiation induced by tumor cells." in: Cancer research, Vol. 61, Issue 7, pp. 3096-104, (2001) (PubMed).

    Corbellino, Bestetti, Scalamogna, Calattini, Galazzi, Meroni, Manganaro, Fasan, Moroni, Galli, Parravicini: "Long-term remission of Kaposi sarcoma-associated herpesvirus-related multicentric Castleman disease with anti-CD20 monoclonal antibody therapy." in: Blood, Vol. 98, Issue 12, pp. 3473-5, (2001) (PubMed).

    Haddad, Paczesny, Leblond, Seigneurin, Stern, Achkar, Bauwens, Delwail, Debray, Duvoux, Hubert, Hurault de Ligny, Wijdenes, Durandy, Fischer: "Treatment of B-lymphoproliferative disorder with a monoclonal anti-interleukin-6 antibody in 12 patients: a multicenter phase 1-2 clinical trial." in: Blood, Vol. 97, Issue 6, pp. 1590-7, (2001) (PubMed).

    Kube, Holtick, Vockerodt, Ahmadi, Haier, Behrmann, Heinrich, Diehl, Tesch: "STAT3 is constitutively activated in Hodgkin cell lines." in: Blood, Vol. 98, Issue 3, pp. 762-70, (2001) (PubMed).

    Foussat, Wijdenes, Bouchet, Gaidano, Neipel, Balabanian, Galanaud, Couderc, Emilie: "Human interleukin-6 is in vivo an autocrine growth factor for human herpesvirus-8-infected malignant B lymphocytes." in: European cytokine network, Vol. 10, Issue 4, pp. 501-8, (2000) (PubMed).

  • Target
    IL-6 (IL6) (Interleukin 6 (IL6))
    Alternative Name
    IL-6 (IL6 Products)
    Synonyms
    BSF2 antibody, HGF antibody, HSF antibody, IFNB2 antibody, IL-6 antibody, Il-6 antibody, ILg6 antibody, Ifnb2 antibody, il6 antibody, CHIL-6 antibody, interleukin 6 antibody, interleukin-6 antibody, IL6 antibody, Il6 antibody, il-6 antibody, IL-6 antibody
    Pathways
    TLR Signaling, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagy, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome
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