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Human Monoclonal ALOX15 Primary Antibody for FACS, IF - ABIN2455602
Fredman, Li, Dalli, Chiang, Serhan: Self-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA. in Scientific reports 2012
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Human Monoclonal ALOX15 Primary Antibody for IHC (p), ELISA - ABIN513270
Calandria, Marcheselli, Mukherjee, Uddin, Winkler, Petasis, Bazan: Selective survival rescue in 15-lipoxygenase-1-deficient retinal pigment epithelial cells by the novel docosahexaenoic acid-derived mediator, neuroprotectin D1. in The Journal of biological chemistry 2009
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Cow (Bovine) Polyclonal ALOX15 Primary Antibody for WB - ABIN2786489
McCaskie, Beilby, Hung, Chapman, McQuillan, Powell, Thompson, Palmer: 15-Lipoxygenase gene variants are associated with carotid plaque but not carotid intima-media thickness. in Human genetics 2008
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Human Polyclonal ALOX15 Primary Antibody for WB - ABIN513269
Leconet, Petit, Peraldi-Roux, Bresson: Nonviral delivery of small interfering RNA into pancreas-associated immune cells prevents autoimmune diabetes. in Molecular therapy : the journal of the American Society of Gene Therapy 2012
Human Polyclonal ALOX15 Primary Antibody for ELISA, WB - ABIN449570
McDuffie, Maybee, Keller, Stevens, Garmey, Morris, Kropf, Rival, Ma, Carter, Tersey, Nunemaker, Nadler: Nonobese diabetic (NOD) mice congenic for a targeted deletion of 12/15-lipoxygenase are protected from autoimmune diabetes. in Diabetes 2007
The crystal structure of a mammalian 12-lipoxygenase reveals a plausible substrate access channel for oxygen.
12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter (show ABCA13 Antibodies) G1.
EPR (show EREG Antibodies) spectroscopy and electrospray mass spectroscopy reveal distinctive features of the iron site in leukocyte arachidonate 12-lipoxygenase (show ALOX12 Antibodies).
Studied human umbilical cord mesenchymal stem cell (hucMSCs) transplantation in DSS (show NR0B1 Antibodies)-induced inflammatory bowel disease (IBD); hucMSC transplantation significantly relieved IBD symptoms thru the regulation of 15-LOX-1 expression and modulation of inflammatory responses in macrophages.
These results indicated that 15-LOX-1 is a potential target for inhibiting the trafficking of DCs to lymphoid organs and inflamed tissues and decreasing the inflammatory response attenuating symptoms of certain immunologic and inflammatory disorders such as dermatitis.
Kelavkar and Badr (1999) stated that the ALOX15 gene maps to 17p13.3 in close proximity to the tumor-suppressor gene TP53 (show TP53 Antibodies) and stated that the ALOX15 gene product is implicated in antiinflammation, membrane remodeling, and cancer development/metastasis.
we propose that increased ALOX15 expression in heart tissue under ischemic conditions may lead to increased production of 15-HETE, potentially contributing to thrombosis.
the results of the present study indicated that the natural products, CA, quercetin and morin hydrate, offer potential as adjuvant therapeutic agents for SMinduced toxicity, not only by reducing inflammation mediated by the p38 (show CRK Antibodies) and LOX (show LOX Antibodies) signaling pathways, but also by decreasing the generation of ROS (show ROS1 Antibodies) and nitrate/nitrite.
15-LOX-1 re-expression downregulates the expression of MTA1 (show MTA1 Antibodies) in colorectal cancer cell lines.
The molecular origin of substrate specificity of 15-LOX-1 for linoleic acid in comparison with arachidonic acid has been analyzed.
Hypoxia increase the production of ROS (show ROS1 Antibodies) through the 15-Lipoxygenase/15-Hydroxyeicosatetraenoiccid pathway.
The role of 15-LOX-1 in colitis and colitis-associated colorectal cancer
variation in inflammation related genes ALOX15 and IL6 (show IL6 Antibodies) was associated with bone microarchitecture and density in young adult women, but appears to be less important in the elderly
Results indicate 15-lipoxygenase modified LDL as a new inducer for LOX-1 (show OLR1 Antibodies) expression and as a new ligand for LOX-1 (show OLR1 Antibodies).
Findings suggest a pivotal role for 12/15-lipoxygenase (12/15-LOX) in both caspase (show CASP3 Antibodies)-dependent and caspase (show CASP3 Antibodies)-independent apoptotic pathways following global cerebral ischemia and suggest a novel therapeutic approach to reduce brain injury following cardiac arrest.
The present study investigated the roles of arachidonate 15-lipoxygenase (Alox15) in the clearance of dying adipocytes by adipose tissue macrophages.
data support that endothelial, rather than monocytic/macrophagic, 12/15-LO has a critical role in hyperglycemia-induced ICAM-1 (show ICAM1 Antibodies) expression, leukocyte adhesion, and subsequent local retinal barrier dysfunction.
This study determined that 1) deletion of 12/15-lipoxygenase (LOX (show LOX Antibodies)) promotes the generation of epoxyeicosatrienoic acids, the cytochrome P-450 (show CYP Antibodies)-derived metabolites in postmyocardial infarction (post-MI) healing; 2) acute exposure of fatty acids to 12/15-LOX(-/-) mice drives leukocyte (neutrophils and macrophages) clearance post-MI; and 3) metabolic transformation of fats is the significant contributor in leukocyte clearance
These data suggest that systemic inactivation of the Alox15 gene normalizes the reduced fertility of male Sec46Ala-Gpx4(+/-) mice by improving the motility of their sperm. If these data can be confirmed in humans, ALOX15 inhibitors might counteract male infertility related to GPX4 deficiency.
The 12/15-LOX plays an important role in the metabolism of eicosanoids in response to allergen-induced airway inflammation.
12/15-LO-derived oxidized lipids regulate histone modifications associated with profibrotic gene expression in MCs (show SMCP Antibodies), and 12/15-LO can mediate similar actions of TGF-beta1 (show TGFB1 Antibodies) and diabetes.
In experimental postoperative ileus, 12/15-lipoxygenase was expressed, mainly in CX3CR1 (show CX3CR1 Antibodies)(+)/Ly6C(+) infiltrating monocytes, not Ly6G(+) neutrophils. 12/15-LOX mediates ileus resolution by producing proresolving docosahexaenoic acid-derived protectin (show CD59 Antibodies) DX.
we show that oxidized phospholipids generated by 12/15-LOX can act as substrates for key proteins required for effective autophagy and that cells deficient in this enzyme show evidence of autophagic dysfunction
SHH (show SHH Antibodies)-responsive 5-lipoxygenase (show ALOX5 Antibodies), 15-lipoxygenase and COX-2 (show COX2 Antibodies) modulate Dectin-1 (show CLEC7A Antibodies)-induced inflammatory cytokines.
demonstrates 12-lipoxygenase and some 15-lipoxygenase enzyme activity
, Arachidonate 15-lipoxygenase
, arachidonate 12-lipoxygenase, 12S-type
, arachidonate omega-6 lipoxygenase
, erythroid cell-specific 15-lipoxygenase
, omega-6 lipoxygenase
, arachidonate 12-lipoxygenase, leukocyte-type