Browse our CCL21 Proteins (CCL21)

Full name:
Chemokine (C-C Motif) Ligand 21 Proteins (CCL21)
On are 57 Chemokine (C-C Motif) Ligand 21 (CCL21) Proteins from 18 different suppliers available. Additionally we are shipping CCL21 Antibodies (191) and CCL21 Kits (51) and many more products for this protein. A total of 308 CCL21 products are currently listed.
6Ckine, ccl21, Ccl21b, CKb9, ECL, exodus-2, Scya21, Scya21b, Scya21c, SLC, TCA4
list all proteins Gene Name GeneID UniProt
CCL21 6366 O00585
CCL21 65956 P86792 , P86793

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CCL21 Proteins (CCL21) by Origin

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Top referenced CCL21 Proteins

  1. Human CCL21 Protein expressed in Baculovirus infected Insect Cells - ABIN2002927 : Christopherson, Campbell, Hromas: Transgenic overexpression of the CC chemokine CCL21 disrupts T-cell migration. in Blood 2001 (PubMed)
    Show all 3 references for 2002927

  2. Human CCL21 Protein expressed in Escherichia coli (E. coli) - ABIN2666610 : Hedrick, Zlotnik: Identification and characterization of a novel beta chemokine containing six conserved cysteines. in Journal of immunology (Baltimore, Md. : 1950) 1997 (PubMed)
    Show all 3 references for 2666610

  3. Rhesus Monkey CCL21 Protein expressed in Baculovirus infected Insect Cells - ABIN2009910 : Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ... in Genome research 2003 (PubMed)
    Show all 2 references for 2009910

  4. Human CCL21 Protein expressed in Escherichia coli (E. coli) - ABIN667761 : Gunn, Tangemann, Tam, Cyster, Rosen, Williams: A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
    Show all 2 references for 667761

More Proteins for CCL21 Interaction Partners

Human Chemokine (C-C Motif) Ligand 21 (CCL21) interaction partners

  1. Results provide evidence for an association between an increase level of CCL21 and IP-10 (show CXCL10 Proteins) in the blood and pulmonary involvement in systemic lupus erythematosus patients.

  2. Gata1 (show GATA1 Proteins)-KO(DC) DCs have reduced polysialic acid levels on their surface, which is a known determinant for the proper migration of DCs toward CCL21.

  3. CCL21 and CXCL13 (show CXCL13 Proteins) levels are increased in the minor salivary glands of patients with Sjogren's syndrome.

  4. Deletion of this extended C-terminus reduces CCL21's affinity for heparin and transferring the CCL21 C-terminus to CCL19 (show CCL19 Proteins) enhances heparin binding mainly through non-specific, electrostatic interactions

  5. CCL21/CCR7 (show CCR7 Proteins) interaction contributes to the time-dependent proliferation of PTC (show F9 Proteins) cells by upregulating cyclin A (show CCNA2 Proteins), cyclin B1 (show CCNB1 Proteins) and cyclin-dependent kinase 1 (CDK1 (show CDK1 Proteins)) expression via the extracellular signal-regulated kinase (ERK (show EPHB2 Proteins)) pathway associated with iodine.

  6. CCL21 can facilitate chemoresistance and stem cell property of colorectal cancer cells via the upregulation of P-gp (show ABCB4 Proteins), Bmi-1 (show BMI1 Proteins), Nanog (show NANOG Proteins), and OCT-4 (show POU5F1 Proteins) through AKT (show AKT1 Proteins)/GSK-3beta/Snail (show SNAI1 Proteins) signals.

  7. CCL21/CCR7 (show CCR7 Proteins) induce VEGF-D (show Figf Proteins) up-regulation and promote lymphangiogenesis via ERK (show EPHB2 Proteins)/Akt (show AKT1 Proteins) pathway in lung cancer.

  8. Our findings suggested that MUC1 (show MUC1 Proteins) plays an important role in CCL21-CCR7 (show CCR7 Proteins)-induced lymphatic metastasis and may serve as a therapeutic target in esophageal squamous cell carcinoma .

  9. TGF-beta1 (show TGFB1 Proteins) promoted CCL21 expression in lymphatic endothelial cells. CCL21 acted in a paracrine fashion to mediate chemotactic migration of EMT (show ITK Proteins) cells toward lymphatic endothelial cells.

  10. The chemotactic interaction between CCR7 (show CCR7 Proteins) and its ligand, CCL21, may be a critical event during progression in pancreatic cancer

Mouse (Murine) Chemokine (C-C Motif) Ligand 21 (CCL21) interaction partners

  1. the CCR7 (show CCR7 Proteins)/CCL21 signaling pathway leading to T lymphocyte migration on fibronectin (show FN1 Proteins) is a beta1 integrin-dependent pathway involving transient ERK1/2 phosphorylation, which is modulated by PLCgamma1 (show PLCG1 Proteins)

  2. Data suggest that lymphotoxin (show LTB Proteins)-dependent and -independent regulation of CC chemokine ligand 21-b and -c plays a role in balancing the central and peripheral immune responses between lymphoid and nonlymphoid tissues.

  3. CCL21 and, to a lesser extent, CCL19 (show CCL19 Proteins) play significant roles in the distinctive localization of marginal zone macrophages within the splenic marginal zone.

  4. CCL21 and 5'-Nase may be involved in the interaction between infiltrating cells and lymphatic vessels to induce the functional changes of lymphatic endothelial cells during insulitic and diabetic development

  5. CXCL9 (show CXCL9 Proteins) has a role in graft rejection in the absence of CCL19 (show CCL19 Proteins) and CCL21

  6. T-cell defects in the nasal-associated lymphoid tissue of lymphotoxin (show LTB Proteins)(-/-) mice can be attributed to the impaired expression of CCL21.

  7. alpha-GalCer-loaded dendritic cells expressing tumor-associated antigen along with SLC (show CCL21A Proteins) can stimulate multiple subsets of effector cells to induce a potent therapeutic effect against peritoneally disseminated tumor cells.

  8. following Leishmania donovani infection of mice, the migration of splenic DC is regulated by the CCR7 (show CCR7 Proteins) ligands CCL19 (show CCL19 Proteins)/CCL21

  9. Results suggest that CCR7 (show CCR7 Proteins)-positive fibrocytes infiltrate the kidney via CCL21-positive vessels, thereby contributing to the pathogenesis of renal fibrosis.

  10. The presence of CCL21 during the in vitro stimulation of CD4 (show CD4 Proteins)+ T cells with anti-CD3 (show CD3E Proteins) plus anti-CD28 (show CD28 Proteins) significantly enhanced in vitro AICD induction of the restimulated T cells, partially through enhancing expression of Fas ligand (show FASL Proteins).

CCL21 Protein Profile

Protein Summary

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).

Alternative names and synonyms associated with CCL21

  • chemokine (C-C motif) ligand 21 (CCL21)
  • CCL21 (SLC)
  • C-C motif chemokine 21 (ccl21)
  • small inducible cytokine A24 (LOC100354652)
  • chemokine (C-C motif) ligand 21C (leucine) (Ccl21c)
  • 6Ckine protein
  • ccl21 protein
  • Ccl21b protein
  • CKb9 protein
  • ECL protein
  • exodus-2 protein
  • Scya21 protein
  • Scya21b protein
  • Scya21c protein
  • SLC protein
  • TCA4 protein

Protein level used designations for CCL21

C-C motif chemokine 21 , CC chemokine ligand 21 , putative CCL21 chemokine , small inducible cytokine A21 , CCL21 , small inducible cytokine A24 , Efficient Chemoattractant for Lymphocytes , beta chemokine exodus-2 , secondary lymphoid tissue chemokine , small inducible cytokine subfamily A (Cys-Cys), member 21 , chemokine CCL21/6CKINE , small-inducible cytokine A21 , C-C motif chemokine 21b , C-C motif chemokine 21c , Ccl21-leu , Small-inducible cytokine A21b , beta-chemokine exodus-2 , small inducible cytokine A21c , small-inducible cytokine A21c , thymus-derived chemotactic agent 4

448796 Canis lupus familiaris
448797 Sus scrofa
511112 Bos taurus
746205 Pan troglodytes
100144337 Oryctolagus cuniculus
100196238 Salmo salar
100354652 Oryctolagus cuniculus
6366 Homo sapiens
574183 Macaca mulatta
65956 Mus musculus
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