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anti-Mouse (Murine) CCR7 Antibodies:
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Human Polyclonal CCR7 Primary Antibody for ELISA, FACS - ABIN152135
Schweickart, Raport, Godiska, Byers, Eddy, Shows, Gray: Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2. in Genomics 1995
Show all 31 Pubmed References
Human Monoclonal CCR7 Primary Antibody for FACS - ABIN4895614
Santra, Tomaras, Warrier, Nicely, Liao, Pollara, Liu, Alam, Zhang, Cocklin, Shen, Duffy, Xia, Schutte, Pemble Iv, Dennison, Li, Chao, Vidnovic, Evans, Klein, Kumar, Robinson, Landucci, Forthal et al.: Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques. ... in PLoS pathogens 2015
Show all 34 Pubmed References
Human Monoclonal CCR7 Primary Antibody for FACS - ABIN4895619
Kaur, Sanford, Garry, Lang, Klumpp, Watanabe, Bronson, Lifson, Rosati, Pavlakis, Felber, Knipe, Desrosiers: Ability of herpes simplex virus vectors to boost immune responses to DNA vectors and to protect against challenge by simian immunodeficiency virus. in Virology 2006
Show all 34 Pubmed References
Human Monoclonal CCR7 Primary Antibody for FACS - ABIN4895613
Wilson, Ives, Rao, Lau, Payne, Kobayashi, Arkwright, Peake, Wong, Adelstein, Smart, French, Fulcher, Picard, Bustamante, Boisson-Dupuis, Gray, Stepensky, Warnatz, Freeman, Rossjohn, McCluskey et al.: STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function. ... in The Journal of experimental medicine 2015
Show all 34 Pubmed References
Human Monoclonal CCR7 Primary Antibody for FACS - ABIN4895618
Billingsley, Rajakumar, Connole, Salisch, Adnan, Kuzmichev, Hong, Reeves, Kang, Li, Li, Haase, Johnson: Characterization of CD8+ T cell differentiation following SIVΔnef vaccination by transcription factor expression profiling. in PLoS pathogens 2015
Show all 34 Pubmed References
Human Monoclonal CCR7 Primary Antibody for CyTOF, FACS - ABIN4899110
Lee, Fertig, Jin, Sukumar, Pandey, Popel: Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis. in Nature communications 2014
Show all 46 Pubmed References
Human Monoclonal CCR7 Primary Antibody for FACS - ABIN2689061
Kim, Pelus, White, Broxmeyer: Macrophage-inflammatory protein-3 beta/EBI1-ligand chemokine/CK beta-11, a CC chemokine, is a chemoattractant with a specificity for macrophage progenitors among myeloid progenitor cells. in Journal of immunology (Baltimore, Md. : 1950) 1998
Show all 10 Pubmed References
Human Monoclonal CCR7 Primary Antibody for FACS - ABIN2689059
Birkenbach, Josefsen, Yalamanchili, Lenoir, Kieff: Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. in Journal of virology 1993
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Human Monoclonal CCR7 Primary Antibody for FACS - ABIN2689060
Burgstahler, Kempkes, Steube, Lipp: Expression of the chemokine receptor BLR2/EBI1 is specifically transactivated by Epstein-Barr virus nuclear antigen 2. in Biochemical and biophysical research communications 1995
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Human Monoclonal CCR7 Primary Antibody for FACS - ABIN4895609
Iyer, Gangadhara, Victor, Gomez, Basu, Hong, Labranche, Montefiori, Villinger, Moss, Amara: Codelivery of Envelope Protein in Alum with MVA Vaccine Induces CXCR3-Biased CXCR5+ and CXCR5- CD4 T Cell Responses in Rhesus Macaques. in Journal of immunology (Baltimore, Md. : 1950) 2015
Show all 7 Pubmed References
Ccr7 functions during axis formation as a GPCR (show GPRC6A Antibodies) to inhibit beta-catenin (show CTNNB1 Antibodies), likely by promoting Ca(2 (show CA2 Antibodies)+) transients throughout the blastula.
Prominent mucosal immune responses in CCR7-deficient mice increased the efficiency of bacteria clearance from the FRT(female reproductive tract) while reducing tissue-associated inflammation and pathology; increased numbers of lymphocytes within the FRT result in pathogen clearance with reduced immune-mediated pathology
CCR7 is required to mount a robust immune response against enteropathogenic Y. pseudotuberculosis by promoting Th17-like responses in mesenteric lymph nodes.
CCR7 overexpression and RelB (show RELB Antibodies) knockdown (KD) in imDCs improve skin-graft survival in a murine skin-transplantation model. Transfection with Ad-CCR7 and RelB (show RELB Antibodies) KD in imDCs may be an effective approach inducing immune tolerance, thus being potentially valuable for inhibiting allograft rejection.
data point to Ccr7 as a critical host defense restriction factor limiting neuroinflammation during acute West Nile virus infection
The results suggest that CCR7 plays a causal role in maintaining innate and adaptive immunity in obesity.
these data indicate that CCR7 and BTLA (show BTLA Antibodies) cooverexpression imparts an intermediate immune phenotype in mmature dendritic cells when compared to that in CCR7- or BTLA (show BTLA Antibodies)-expressing counterparts that show a more immunocompetent or immunotolerant phenotype
Results suggest that baicalin exerts an inhibitory effect on airway inflammation, and this effect may be associated with the inhibition of CCR7 and its ligands, CCL19 (show CCL19 Antibodies) and CCL21 (show CCL21 Antibodies), as well as on the nuclear factor-Kappa B (NF-kappaB (show NFKB1 Antibodies)) pathway in a mouse model of asthma.
This study reveals a role for CCR7 in limiting Treg recirculation back to the thymus and enables separation of the mechanisms controlling Treg production and thymic recirculation.
data reveal that CCR7 plays multifaceted roles in regulating collecting vessel permeability and fibrosis, with one of the key players being IRF4 (show IRF4 Antibodies)-dependent DCs.
the graft site microenvironment plays a critical role in alloimmunity by determining DC trafficking through the CCR7-CCL19 (show CCL19 Antibodies)/21 axis.
The analysis of gene amplification and mRNA levels showed the expression of CCR7 in breast cancer correlated with better prognosis.
that CCR7 mediates TGF-beta1 (show TGFB1 Antibodies)-induced MMP2 (show MMP2 Antibodies)/9 expression through NF-kappaB (show NFKB1 Antibodies) signaling
leukocyte subsets express distinct patterns of CCR7 sialylation that contribute to receptor signaling and fine-tuning chemotactic responses.
tumor microenvironment stimulation down-regulated the migration of CCR7-expressing tumor cells toward CCL21 (show CCL21 Antibodies) and inhibited the formation of directional protrusions toward CCL21 (show CCL21 Antibodies) in a novel 3-dimensional hydrogel system.
CCR7 expression levels in human tumors correlate with signatures of CD141 (show THBD Antibodies)(+) DC, intratumoral T cells, and better clinical outcomes.
specific role for CCL21/CCR7 in promoting EMT and metastasis in CD133+ pancreatic cancer stem-like cells
This study showed that CCR7 are overexpressed in CD4 (show CD4 Antibodies)(-) CD8 (show CD8A Antibodies)(-) thymocytes of myasthenia gravis patients.
High tumoral CCR7 expression correlated with potential lymphatic involvement and poor prognosis of metastatic renal cell carcinoma (show MOK Antibodies) patients treated with tyrosine kinase (show TXK Antibodies) inhibitors.
Results show that upregulation of CCR7 promotes cell proliferation and inflammation in A549 non-small cell lung cancer cells. However, silencing of CCR7 via siRNA treatment promotes cell apoptosis and suppresses the inflammatory response and TGF-beta1 (show TGFB1 Antibodies)-induced EMT (show ITK Antibodies), which may be associated with NF-kappaB (show NFKB1 Antibodies) signaling.
Down-regulating CCR7 expression in MG63 cells could apparently inhibit cell proliferation, migration and invasion abilities of MG63 cells, and also induce cell apoptosis.
Fluorescent dye-labeled gammadelta T cells from afferent and efferent lymph lack CCR7 surface expression and display high levels of CD62L (show SELL Antibodies) compared with CD4 (show CD4 Antibodies) T cells, which do express CCR7.
CCR7 transcripts were minimally expressed in ex vivo and proliferating WC1(+)gammadelta T cells, a unique cell population with proinflammatory characteristics
the pattern of expression of CCR7 in different populations of porcine lymphocytes appears to be similar to that of human, highlighting the value of the pig as a useful animal model for biomedical studies.
Pre-translntation of sertli cell CCR7 significantly suppresses lymphocyte proliferation and prolongs allogeneic skin graft survival.
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor.
C-C chemokine receptor type 7
, CC chemokine receptor 7
, chemokine (C-C motif) receptor 7 a
, chemokine (C-C motif) receptor 7
, c-C chemokine receptor type 7-like
, C-C CKR-7
, EBV-induced G-protein coupled receptor 1
, MIP-3 beta receptor
, chemokine (C-C) receptor 7
, epstein-Barr virus-induced G-protein coupled receptor 1
, EBV-induced G protein-coupled receptor 1
, Epstein-Barr virus induced G-protein coupled receptor
, Epstein-Barr virus induced gene 1
, lymphocyte-specific G protein-coupled peptide receptor
, chemokine receptor 7