Browse our anti-HAX1 (HAX1) Antibodies

Full name:
anti-HCLS1 Associated Protein X-1 Antibodies (HAX1)
On www.antibodies-online.com are 143 HCLS1 Associated Protein X-1 (HAX1) Antibodies from 19 different suppliers available. Additionally we are shipping HAX1 Proteins (12) and HAX1 Kits (4) and many more products for this protein. A total of 165 HAX1 products are currently listed.
Synonyms:
HAX-1, hax1, HCLSBP1, Hs1bp1, HSP1BP-1, mHAX-1s, SCN3, SIG-111, Silg111

Most Popular Reactivities for anti-HAX1 (HAX1) Antibodies

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Top referenced anti-HAX1 Antibodies

  1. Human Monoclonal HAX1 Primary Antibody for WB - ABIN393488 : Burnicka-Turek, Kata, Buyandelger, Ebermann, Kramann, Burfeind, Hoyer-Fender, Engel, Adham: Pelota interacts with HAX1, EIF3G and SRPX and the resulting protein complexes are associated with the actin cytoskeleton. in BMC cell biology 2010 (PubMed)
    Show all 5 references for 393488

  2. Human Polyclonal HAX1 Primary Antibody for EIA, IHC (p) - ABIN952684 : Johns, Doceul, Everett, Crooke, Charleston, Seago: The classical swine fever virus N-terminal protease N(pro) binds to cellular HAX-1. in The Journal of general virology 2010 (PubMed)
    Show all 3 references for 952684

  3. Human Monoclonal HAX1 Primary Antibody for EIA, WB - ABIN400856 : Klein, Grudzien, Appaswamy, Germeshausen, Sandrock, Schäffer, Rathinam, Boztug, Schwinzer, Rezaei, Bohn, Melin, Carlsson, Fadeel, Dahl, Palmblad, Henter, Zeidler, Grimbacher, Welte: HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease). in Nature genetics 2006 (PubMed)
    Show all 2 references for 400856

  4. Human Polyclonal HAX1 Primary Antibody for ELISA, WB - ABIN449906 : Chao, Parganas, Boyd, Hong, Opferman, Ihle: Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons. in Nature 2008 (PubMed)

  5. Human Monoclonal HAX1 Primary Antibody for IF, IP - ABIN968198 : Suzuki, Demoliere, Kitamura, Takeshita, Deuschle, Watanabe: HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases. in Journal of immunology (Baltimore, Md. : 1950) 1997 (PubMed)

  6. Cow (Bovine) Polyclonal HAX1 Primary Antibody for IHC, WB - ABIN2784795 : Lees, Hart, Marshall: Existence of multiple isoforms of HS1-associated protein X-1 in murine and human tissues. in Journal of molecular biology 2008 (PubMed)

  7. Human Polyclonal HAX1 Primary Antibody for IHC (p), WB - ABIN656245 : Han, Goldstein, Hou, Froelich, Watkins, Rabinowich: Deregulation of mitochondrial membrane potential by mitochondrial insertion of granzyme B and direct Hax-1 cleavage. in The Journal of biological chemistry 2010 (PubMed)

More Antibodies against HAX1 Interaction Partners

Human HCLS1 Associated Protein X-1 (HAX1) interaction partners

  1. results suggest that miR (show MLXIP Antibodies)-223 increases the sensitivity of TNBCSCs to TRAIL-induced apoptosis by targeting HAX-1

  2. The authors describe the first case series of patients with CN caused by HAX1 mutation who presented with HLH. They hypothesize that severe neutropenia persists after an HLH episode in children without FHLH mutations (especially infants) because these patients have CN caused by HAX1 mutations.

  3. Study indicates that the overexpression of HAX-1 is essential in the development of chemoresistance in breast cancer.

  4. Kv3.3 (show KCNC3 Antibodies) regulates Arp2 (show ACTR2 Antibodies)/3-dependent cortical actin nucleation mediated by Hax-1; resulting cortical actin structures interact with the channel's gating machinery to slow its inactivation rate during sustained membrane depolarizations; a mutation that leads to late-onset spinocerebellar ataxia (show USP14 Antibodies) type 13.

  5. Results show that mRNA and protein levels of HAX-1 in prostate cancer cell lines were significantly higher and inhibits cell apoptosis through caspase-9 (show CASP9 Antibodies) inactivation.

  6. HAX-1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation.

  7. HAX1 knockdown significantly decreased the proliferation. In addition, the expression levels of ki67 (show MKI67 Antibodies) and phosphorylatedakt were inhibited following HAX1 knockdown.

  8. HAX-1 was significantly elevated in laryngeal carcinoma.

  9. Authors showed that HAX1 promotes auto-ubiquitination and degradation of cIAPs by facilitating the intermolecular homodimerization of RING finger (show PCGF1 Antibodies) domain.

  10. HAX-1 is involved in mRNA processing as an element of P-body interaction network.

Mouse (Murine) HCLS1 Associated Protein X-1 (HAX1) interaction partners

  1. HAX1 plays a general role in B cell receptor-mediated internalization events and BCR (show BCR Antibodies)-mediated apoptosis.

  2. The hydrophilic sequences within loop 2, and the matrix-localized hydrophilic domain of UCP3 (show UCP3 Antibodies), were necessary for binding to Hax-1 at the C-terminal domain, adjacent to the mitochondrial inner membrane.

  3. Protease Omi (show HTRA2 Antibodies) impairs mitochondrial function by cleaving Hax-1, which induces apoptosis in oxygen-glucose deprivation and reoxygenation -treated N2a cells and causes reperfusion injury in middle cerebral artery occlusion mice.

  4. Knockdown of HAX1 and EB2 (show MAPRE2 Antibodies) in skin epidermal cells stabilizes focal adhesions and impairs epidermal migration.

  5. These findings reveal the role of HAX-1 in regulating cyclophilin-D (show PPIF Antibodies) levels via an Hsp90 (show HSP90 Antibodies)-dependent mechanism, resulting in protection against activation of mPTP (show PTPN2 Antibodies) and subsequent cell death responses.

  6. anti-apoptotic role of HAX-1 versus BCL-XL (show BCL2L1 Antibodies) in cytokine-dependent bone marrow-derived cells

  7. The expression of Hax-1 in normal brain tissue and reduction of Hax-1 in ischemic brain tissue indicate its possible involvement in pathophysiological functions in the brain.

  8. Cardiac ischemia-reperfusion injury is associated with decreases in HAX-1 levels. Overexpression of HAX-1 promotes cardiomyocyte survival, via its interaction with Hsp90 (show HSP90 Antibodies) and specific inhibition of IRE-1 (show ERN1 Antibodies) signaling at the ER/sarcoplasmic reticulum.

  9. Focal cerebral ischemia significantly decreased cytosolic accumulation of HAX-1, induced an upregulation of HtrA2 (show HTRA2 Antibodies), an upregulation of AIF (show AIFM1 Antibodies) and activation of caspase-3 (show CASP3 Antibodies)

  10. HAX1 deficiency: impact on lymphopoiesis and B-cell development.

HAX1 Antigen Profile

Antigen Summary

The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with HAX1

  • HCLS1 associated protein X-1 (HAX1) antibody
  • HCLS1-associated protein X-1 (hax1) antibody
  • zgc:92196 (zgc:92196) antibody
  • HCLS1 associated protein X-1 (LOC100348155) antibody
  • HCLS1 associated protein X-1 (Hax1) antibody
  • HCLS1 associated X-1 (Hax1) antibody
  • HAX-1 antibody
  • hax1 antibody
  • HCLSBP1 antibody
  • Hs1bp1 antibody
  • HSP1BP-1 antibody
  • mHAX-1s antibody
  • SCN3 antibody
  • SIG-111 antibody
  • Silg111 antibody

Protein level used designations for HAX1

HCLS1 associated protein X-1 , HCLS1-associated protein X-1 , HAX-1 , HCLS1 (and PKD2) associated protein , HS1 binding protein , HS1-associating protein X-1 , HS1-binding protein 1 , HSP1BP-1 , HS1-associated protein X-1

GENE ID SPECIES
457347 Pan troglodytes
100194877 Salmo salar
436609 Danio rerio
100348155 Oryctolagus cuniculus
10456 Homo sapiens
480134 Canis lupus familiaris
506895 Bos taurus
291202 Rattus norvegicus
23897 Mus musculus
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