Browse our Nephrin (NPHS1) ELISA Kits

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Nephrosis 1, Congenital, Finnish Type (Nephrin) ELISA Kits (NPHS1)
On www.antibodies-online.com are 44 Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1) ELISA Kits from 9 different suppliers available. Additionally we are shipping Nephrin Antibodies (190) and Nephrin Proteins (20) and many more products for this protein. A total of 263 Nephrin products are currently listed.
Synonyms:
CNF, nephrin, NephrinB, NPHN, nphs1, nphs1l
list all ELISA KIts Gene Name GeneID UniProt
NPHS1 4868 O60500
NPHS1 64563 Q9R044
NPHS1 54631 Q9QZS7

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Top referenced Nephrin ELISA Kits

  1. Rat (Rattus) Nephrin ELISA Kit for Sandwich ELISA - ABIN431840 : Alter, Kretschmer, Von Websky, Tsuprykov, Reichetzeder, Simon, Stasch, Hocher: Early urinary and plasma biomarkers for experimental diabetic nephropathy. in Clinical laboratory 2012 (PubMed)

  2. Human Nephrin ELISA Kit for Sandwich ELISA - ABIN1116131 : Petrica, Vlad, Gluhovschi, Gadalean, Dumitrascu, Gluhovschi, Velciov, Bob, Vlad, Popescu, Milas, Ursoniu: Proximal tubule dysfunction is associated with podocyte damage biomarkers nephrin and vascular endothelial growth factor in type 2 diabetes mellitus patients: a cross-sectional study. in PLoS ONE 2014 (PubMed)

More ELISA Kits for Nephrin Interaction Partners

Zebrafish Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1) interaction partners

  1. zApoL1 is essential for proper blood filtration in the zebrafish glomerulus and that zApoL1 affects the expression of nephrin

  2. Nephrin signal bordered the lateral membrane of podocytes, which were columnar in shape

  3. Using two models, zebrafish and mice, that the absence of nephrin results in poorly developed muscles and incompletely fused myotubes, respectively.

Human Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1) interaction partners

  1. WHSC1L1 (show WHSC1L1 ELISA Kits)-L acts as a histone methyltransferase in podocytes and regulates nephrin gene expression, which may in turn contribute to the integrity of the slit diaphragm of the glomerular filtration barrier.

  2. Two novel putatively deleterious NPHS1 variants were identified in children with steroid-resistant nephrotic syndrome.

  3. On genetic analysis of NPHS1 a paternally derived heterozygous frame-shift mutation caused by an 8 bp deletion, resulting in a stop codon in exon 16 (c.2156-2163 delTGCACTGC causing p.L719DfsX4), and a novel, maternally derived nonsense mutation in exon 15 (c.1978G>T causing p.E660X) were identified.

  4. Case Reports: NPHS1 mutations in four Brazilian cases of congenital nephrotic syndrome.

  5. The classical form is CNF, which is caused by mutations in the nephrin gene (NPHS1), leading to massive proteinuria, hypoproteinemia and edema in the newborn period

  6. there is a link found of the glomerular protein nephrin and the antihypertensive action of angiotensin receptor antagonists in the treatment of hypertension.

  7. A novel nonsense mutation in NPHS1 linking aortic stenosis associated with congenital nephropathy, is reported.

  8. Activated IQGAP1, as an intracellular partner of nephrin, is involved in actin cytoskeleton organization and functional regulation of podocytes.

  9. NPHS1 rs437168 variant is associated with nephrotic syndrome in children.

  10. biochemical reconstitution on supported lipid bilayers of protein clusters containing the adhesion receptor Nephrin and its cytoplasmic partners, Nck (show NCK1 ELISA Kits) and N-WASP (show WASL ELISA Kits), is reported.

Mouse (Murine) Nephrosis 1, Congenital, Finnish Type (Nephrin) (NPHS1) interaction partners

  1. WHSC1L1 (show WHSC1L1 ELISA Kits)-L acts as a histone methyltransferase in podocytes and regulates nephrin gene expression, which may in turn contribute to the integrity of the slit diaphragm of the glomerular filtration barrier.

  2. Data (including data from studies using transgenic mice, an murine experimental model of diabetes, and mouse/human cell lines) suggest prostaglandin I2 receptor (Ptgir (show PTGIR ELISA Kits)) is involved in insulin (show INS ELISA Kits) secretion in pancreatic beta-cells and in permselectivity in glomerular podocytes; the mechanism appears to involve regulation of post-translational phosphorylation of nephrin.

  3. the interaction between nephrin and MAGI-1 regulates Rap1 activation in podocytes to maintain long term slit diaphragm structure

  4. interaction of full-length suPAR with alphavbeta3 integrin expressed on podocytes results in down-modulation of nephrin that may affect kidney functionality in different human pathologies characterized by increased concentration of suPAR.

  5. Nphs1 is an activity dependent gene in mouse olfactory sensory neurons.

  6. ACE2 (show ACE2 ELISA Kits) deficiency exacerbates kidney inflammation, oxidative stress and adverse renal injury in the ApoE (show APOE ELISA Kits)-mutant mice through modulation of the nephrin, NOX4 (show NOX4 ELISA Kits) and TNF-alpha (show TNF ELISA Kits)-TNFRSF1A (show TNFRSF1A ELISA Kits) signaling.

  7. Nephrin is involved in pancreatic beta-cell survival signaling; a marked decrease in nephrin expression and phosphorylated Akt (show AKT1 ELISA Kits) was observed in pancreatic islets of leptin receptor (show LEPR ELISA Kits)-deficient diabetic mice.

  8. SHP-1 (show PTPN6 ELISA Kits) contributes to nephrin deactivation in podocytes exposed to high glucose levels.

  9. The aPKC-Par3 (show F2RL2 ELISA Kits) complex regulates the cell-surface localization of nephrin.

  10. A novel direct interaction between the Sema3a (show SEMA3A ELISA Kits) signaling receptor plexinA1 and nephrin, linking extracellular Sema3a (show SEMA3A ELISA Kits) signals to the slit-diaphragm signaling complex, was identified.

Nephrin (NPHS1) Antigen Profile

Antigen Summary

This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.

Alternative names and synonyms associated with Nephrin (NPHS1)

  • nephrosis 1, congenital, Finnish type (nephrin) (NPHS1) Elisa Kit
  • nephrosis 1, congenital, Finnish type (nephrin) (nphs1) Elisa Kit
  • nephrin (nphs1) Elisa Kit
  • nephrin (AaeL_AAEL003853) Elisa Kit
  • nephrosis 1, congenital, Finnish type (nephrin) (Nphs1) Elisa Kit
  • nephrosis 1, nephrin (Nphs1) Elisa Kit
  • CNF Elisa Kit
  • nephrin Elisa Kit
  • NephrinB Elisa Kit
  • NPHN Elisa Kit
  • nphs1 Elisa Kit
  • nphs1l Elisa Kit

Protein level used designations for NPHS1

nephrosis 1, congenital, Finnish type (nephrin) , nephrin , renal glomerulus-specific cell adhesion receptor , nephrosis 1 homolog, nephrin , nephrin 1

GENE ID SPECIES
468841 Pan troglodytes
692352 Danio rerio
734213 Xenopus laevis
5579127 Aedes aegypti
4868 Homo sapiens
64563 Rattus norvegicus
100354996 Oryctolagus cuniculus
100713185 Cavia porcellus
100622946 Sus scrofa
484571 Canis lupus familiaris
519706 Bos taurus
101115895 Ovis aries
54631 Mus musculus
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