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anti-Human PREX1 Antibodies:
anti-Mouse (Murine) PREX1 Antibodies:
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Human Polyclonal PREX1 Primary Antibody for ICC, IF - ABIN4342143
Lindsay, Lawn, Campbell, Faller, Rambow, Mort, Timpson, Li, Cammareri, Ridgway, Morton, Doyle, Hegarty, Rafferty, Murphy, McDermott, Sheahan, Pedone, Finn, Groben, Thomas, Hao, Carson, Norman et al.: P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. ... in Nature communications 2011
Show all 3 Pubmed References
Human Polyclonal PREX1 Primary Antibody for ELISA, IHC (p) - ABIN4342144
Qin, Xie, Wang, Hoshino, Wolff, Zhao, Scofield, Dowd, Lin, Tu: Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis. in Oncogene 2009
Data suggest that PREX1 and PREX2 (show DEPDC2 Antibodies) share similarities in amino acid sequence, domain structure, activation by PIP(3) [phosphatidylinositol 3,4,5-triphosphate] and G-protein-coupled receptors beta/gamma subunits; expression of PREX1 and PREX2 (show DEPDC2 Antibodies) is altered in many cancers. [REVIEW]
upon ligation of the T-cell antigen receptor (TCR), the TCR associates with and transactivates CXCR4 (show CXCR4 Antibodies) via phosphorylation of S339-CXCR4 (show CXCR4 Antibodies) in order to activate a PREX1-Rac1-signaling pathway that stabilizes interleukin-2(IL-2 (show IL2 Antibodies)), IL-4 (show IL4 Antibodies), and IL-10 (show IL10 Antibodies) messenger RNA (mRNA) transcripts.
data point to multiple mechanisms of PREX1 negative regulation by PAKs within receptor tyrosine kinase and GPCR-stimulated signaling pathways
PREX1 overexpression reduced staurosporine-induced apoptosis whereas its shRNA knockdown promoted apoptosis in response to staurosporine or the anti-estrogen drug tamoxifen.
An unexpected role for P-Rex1 and Rac1 activation in the genesis of prostate cancer stem cells and resistance to bevacizumab and sunitinib.
P-Rex1 contributes to the spatiotemporal localization of type I PKA, which tightly regulates this guanine exchange factor by a multistep mechanism.
findings suggest a vital role of P-Rex1 signaling in CA1 (show CA1 Antibodies) LTD that is critical for social behavior and cognitive function and offer new insight into the etiology of ASDs
The P-Rex1-Rac1 interface is critical for Rac1 activation in breast cancer cells.
P-REX1 promotes both PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) and MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) signaling in breast cancer.
PREX1 gene promoter hypomethylation is a prognostic marker of poor patient survival.
A novel mechanism of P-Rex1 regulation through the GPCR (show GPBAR1 Antibodies)-adaptor protein Norbin (show NCDN Antibodies).
Tiam1 and P-Rex1 promote Rac1 anti- and pro-migratory signalling cascades.
regulates GPCR-driven Rac signalling and actin polarity in neutrophils
Platelet P-Rex and Vav (show VAV1 Antibodies) family Rac (show AKT1 Antibodies)-GEFs play important proinflammatory roles in leukocyte recruitment.
We have elucidated a proliferative role of P-Rex1 when Rac1 is deleted in melanoblasts.
P-Rex1 may serve as a biomarker to predict response to single-agent PI3K inhibitors within a subset of breast cancers.
In vivo, in an ischemia-reperfusion-induced model of acute kidney injury, abolished selectin-mediated integrin activation contributed to decreased neutrophil recruitment and reduced kidney damage in P-Rex1-deficient mice.
P-rex1 expressed in endothelial cells is a critical mediator of vascular barrier disruption by an upstream pathway.
Data conclude that P-Rex1 has an important role in melanoblast migration and cancer progression to metastasis in mice and humans.
The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
, phosphatidylinositol 3,4,5-trisphosphate-dependent RAC exchanger 1
, phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein-like
, phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
, ptdIns(3,4,5)-dependent Rac exchanger 1
, SET domain containing 6