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Human SLIT2 ELISA Kit for Sandwich ELISA - ABIN414767
Bauer, Dowejko, Bosserhoff, Reichert, Bauer: Slit-2 facilitates interaction of P-cadherin with Robo-3 and inhibits cell migration in an oral squamous cell carcinoma cell line. in Carcinogenesis 2011
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Human SLIT2 ELISA Kit for Sandwich ELISA - ABIN365765
Zhou, Yu, Xie, Huang, Xu, Li: The role of SLIT-ROBO signaling in proliferative diabetic retinopathy and retinal pigment epithelial cells. in Molecular vision 2011
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The alteration of Slit2 (show SLIT3 ELISA Kits) and Robo1 (show ROBO1 ELISA Kits) expression in the retinas of diabetic rats and patients with proliferative diabetic retinopathy suggests a role for the Slit-Robo signal in the various stages diabetic retinopathy.
human placental multipotent mesenchymal stromal cell express Slit2 (show SLIT3 ELISA Kits) and both Robo1 (show ROBO1 ELISA Kits) and Robo4 (show ROBO4 ELISA Kits) are present in human umbilical vein endothelial cells.
Slit2 (show SLIT3 ELISA Kits)-Robo1 (show ROBO1 ELISA Kits) signaling promoted the adhesion, invasion and migration of tongue carcinoma cells by upregulating the expression levels of MMP2 (show MMP2 ELISA Kits) and MMP9 (show MMP9 ELISA Kits) and, downregulating the expression of E-cadherin (show CDH1 ELISA Kits).
findings suggest that AK3 and SLIT2 may be potential candidates involved in genetic susceptibility to colorectal cancer
Low Slit2 expression is associated with glioma.
Results indicate the importance of SLIT2 (show SLIT3 ELISA Kits)-ROBO1 (show ROBO1 ELISA Kits)-CDC42 (show CDC42 ELISA Kits) signaling pathway in predicting tumor progression.
We postulate that Robo1 (show ROBO1 ELISA Kits) promotes tumor invasion partly by the upregulation of MMP2 (show MMP2 ELISA Kits) after activation of PI3K (show PIK3CA ELISA Kits)/Akt (show AKT1 ELISA Kits) signaling pathway. Notably, Slit2 (show SLIT3 ELISA Kits) knockdown caused the upregulation of Robo1 (show ROBO1 ELISA Kits) expression both at the mRNA and protein levels. Thus, the stimulatory effects of Slit2 (show SLIT3 ELISA Kits) knockdown on tumor progression can be ascribed, at least in part, to the upregulation of Robo1 (show ROBO1 ELISA Kits) and its positive role in tumor progression.
expression of the evolutionarily conserved slit2 (show SLIT3 ELISA Kits) Gene Promoter Requires Sp1 (show PSG1 ELISA Kits)
Study shows that Slit2 (show SLIT3 ELISA Kits) mRNA and protein levels were significantly reduced in papillary thyroid cancer (PTC (show F9 ELISA Kits)) specimens and implicates Slit2 (show SLIT3 ELISA Kits) functions as a negative regulator in the development and progression of PTC (show F9 ELISA Kits).
Overexpression of Slit2 induces its tumor suppressive effects in Breast cancer.
While Slit1 (show SLIT1 ELISA Kits) and Robo2 (show ROBO2 ELISA Kits) are only expressed in peripheral axons and their cell bodies, Slit2, Slit3 (show SLIT3 ELISA Kits) and Robo1 (show ROBO1 ELISA Kits) are also expressed in satellite cells of the dorsal root ganglion, Schwann cells and fibroblasts of peripheral nerves.
Transgenic over-expression of slit2 enhances disruption of blood-brain barrier and increases cell death after traumatic brain injury in mice. This suggest that over expression of slit2 plays a detrimental role in the pathophysiology of mild TBI.
Slit2 induces a robust activation of PKA signaling, which is required for its prothermogenic activity.
Robo1-Slit2 interaction required for pathfinding mechanism essential to establish the functionally important habenulo-interpeduncular connection.
Together, these observations suggest that Slit2 serves as a factor utilized by muscle Ctnnb1 (show CTNNB1 ELISA Kits) to direct presynaptic differentiation.
Slit2 acts as a repellant cue to mediate axon guidance in the formation of the anterior commissure.
Slit2/Robo1 (show ROBO1 ELISA Kits) signaling promotes intestinal tumorigenesis through Src (show SRC ELISA Kits)-mediated activation of the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) pathway.
the two genes neuropeptide Y (Npy (show NPY ELISA Kits)) and Slit homolog 2 (Drosophila) (Slit2) gradually increase during aging, and upon suppression of these two genes
Data shows that modulation of angiostatic factor Slit2 by EphA2 receptor regulates endothelial responses to VEGF-mediated angiogenesis and tumor neovascularization.
administration of Slit2 to atherosclerosis-prone LDL receptor (show LDLR ELISA Kits)-deficient mice inhibited monocyte recruitment to nascent atherosclerotic lesions.
These data supports a model whereby Wnt signaling through Frizzled-3a attenuates expression of Slit2 in the rostral midline of the forebrain.
In embryonic axon tracts, Robo2 (show ROBO2 ELISA Kits) responds to signals from slit2 and slit3 (show SLIT3 ELISA Kits).
Data show that Hedgehog (show SHH ELISA Kits) signaling is required for commissure formation, glial bridge formation, and the restricted expression of the guidance molecules slit1a, slit2, slit3 (show SLIT3 ELISA Kits) and sema3d (show SEMA3D ELISA Kits).
Slit acts via Robo2 (show ROBO2 ELISA Kits) in dendrites as a branching/growth factor but not in guidance, while Robo2 (show ROBO2 ELISA Kits) and Robo3 (show ROBO3 ELISA Kits) function in concert in axons to mediate axonal interactions and respond to Slits as guidance factors
Combining Slit2 with VEGFs adjusts VEGFR2 (show KDR ELISA Kits)-mediated angiogenic effects into a more physiological direction
acts as a ligand for glypican-1, a heparan sulfate proteoglycan\; may play a role in neurogenesis and midline development
slit homolog 2 protein
, downregulated during adipocyte differentiation-1
, neurogenic extracellular slit protein
, slit homolog 2 (Drosophila)