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Results of this study provide evidence for a role for spectrin in different steps of megakaryocyte development through its participation in the formation of invaginated membranes and in the maintenance of proplatelet structure.
Mutational characteristics of ANK1 (show ANK1 ELISA Kits) and SPTB genes in Korean hereditary spherocytosis have been described.
a new mutation in the SPTB gene (466insG) leading to a frameshift and a premature stop codon 29 codons downstream in the region encoding the C-terminal part of the dimerization domain; instability of mutant mRNA results in spectrin deficiency and clinically moderate to serious hereditary spherocytosis
Variations in both alpha-spectrin (show SPTAN1 ELISA Kits) (SPTA1 (show SPTA1 ELISA Kits)) and beta-spectrin ( SPTB ) were found in a neonate with prolonged jaundice in a family where nine individuals had hereditary elliptocytosis.
analysis of glycosylation of erythrocyte spectrin and its modification in visceral leishmaniasis
Data postulate that direct interactions between spectrin ankBDn and PE-rich domains play an important role in stabilizing the structure of the spectrin-based membrane skeleton.
Results suggest that it is possible for cellular proteins to differentially associate with the C-termini of different beta-spectrin isoforms to regulate alpha- and beta-spectrin association to form functional spectrin tetramers.
through the use of an ATP-driven phospholipid translocase (flippase), erythrocytes have evolved a protective mechanism against spectrin glycation and thus maintain their optimal membrane function during their long circulatory life span
CD45 lateral mobility is regulated by the spectrin-ankyrin cytoskeleton of T cells
Important region in the beta-spectrin C-terminus for association with the alpha chain and for spectrin tetramer formation is defined.
The spectrin-ankyrin skeleton controls CD45 (show PTPRC ELISA Kits) surface display and interleukin-2 (show IL2 ELISA Kits) production
This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cell membrane organization and stability. The protein encoded by this locus functions in stability of erythrocyte membranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. Alternatively spliced transcript variants have been described.
spectrin, beta, erythrocytic
, spectrin beta
, spectrin, beta, erythrocytic (includes spherocytosis, clinical type I)
, spectrin beta chain, erythrocyte
, beta-I spectrin
, beta-spectrin 1
, brain erythroid spectrin (235E)
, spectrin R
, spectrin beta 1
, spectrin beta chain, erythrocytic
, membrane cytoskeletal protein
, erythroid spectrin beta