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Suggest Y chromosome gene TMSB4Y may function as a tumor suppressor gene in male breast cancer.
TMSB4Y has been found to encode a novel HLA-A*3303-restricted minor histocompatibility H-Y antigen, revealed during cytotoxicity assays of T cell lines from a female-to-male hemopoietic stem cell transplantation patient.
T beta 4 is a key activator of NK cell cytotoxicity.
This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X escapes X inactivation and encodes an actin sequestering protein.
thymosin beta-4, Y isoform
, thymosin beta-4, Y-chromosomal
, thymosin, beta 4, Y chromosome