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WASH deficiency impairs the association of RNF2 (show RNF2 ELISA Kits) with AMBRA1 (show AMBRA1 ELISA Kits) to impede AMBRA1 (show AMBRA1 ELISA Kits) degradation.
WASH complex regulates Arp2 (show AICDA ELISA Kits)/3 complex and is required for cytokinesis and polar body extrusion.
WASH is required for the differentiation commitment of hematopoietic stem cells by acting as an upstream regulator to modulate c-Myc (show MYC ELISA Kits) transcription.
WASH can suppress Beclin 1 (show BECN1 ELISA Kits) ubiquitination to inactivate Vps34 (show PIK3C3 ELISA Kits) activity leading to suppression of autophagy.
WASH is a newly recognized regulator of T cell receptor, CD28 (show CD28 ELISA Kits), LFA-1 (show ITGAL ELISA Kits), and GLUT1 (show SLC2A1 ELISA Kits) endosome-to-membrane recycling.
WASH-mediated F-actin is requisite for the integrity of both endosomal and lysosomal networks in mammalian cells.
WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation, whereas the N-terminal portion is required for its regulation and localization in the cells
show that WASH generates an actin network on a restricted domain of sorting and recycling endosomes.
Stress-internalized EGFR co-segregates with exogenously expressed pre-melanosomal markers OA1 and fibrillar PMEL, following early endosomal sorting by the actin polymerization-promoting WASH complex
FAM21 not only functions as an integral component of the cytoplasmic WASH complex, but also modulates NF-kappaB (show NFKB1 ELISA Kits) gene transcription in the nucleus.
The WASH-VPEF/FAM21-retromer complexe mediates endosome fission and sorting of virus-containing vesicles prior to virus core uncoating in the cytoplasm.
The USP7 deubiquitinating enzyme is an integral component of the MAGE-L2-TRIM27 ligase and is essential for WASH-mediated endosomal actin assembly and protein recycling.
WASH and the exocyst complex are required for matrix degradation by an exocytic mechanism that involves tubular connections between MT1-MMP (show MMP14 ELISA Kits)-positive late endosomes and the plasma membrane in contact with the matrix.
Data show that a component of the WASH regulatory complex (SHRC), FAM21, directly interacts with the retromer CSC protein VPS35 (show vps35 ELISA Kits).
WASH and Arp2 (show ACTR2 ELISA Kits)/3 regulates integrin alpha5beta1-mediated invasive cell migration.
Actin polymerization by WASH influences the shape and maturation of endosomes, and highlights a previously unrecognized role for WASH and the Arp2 (show ACTR2 ELISA Kits)/3 complex in the degradative steps of endocytic trafficking.
WASH exists in a multiprotein complex containing FAM21, which links WASH to endosomes and is required for WASH-dependent retromer-mediated sorting.
Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (By similarity).
WAS protein family homolog 1
, WAS protein family homolog 2
, CXYorf1-like protein on chromosome 9
, FLJ00075 protein
, family with sequence similarity 39, member E
, WAS protein family homolog 2 pseudogene
, family with sequence similarity 39, member B