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Clk1 (show CDK11B Proteins), Clk2 and Clk4 (show CLK4 Proteins) prevent chromatin breakage by regulating the Aurora B (show AURKB Proteins)-dependent abscission checkpoint.
Loss of CLK2 in luminal breast cancer cells leads to the upregulation of epithelial-to-mesenchymal transition (EMT (show ITK Proteins))-related genes and a switch to mesenchymal splice variants of several genes.
LAMMER/Cdc2 (show CDK1 Proteins)-like kinase, represented by Doa and its mammalian homolog CLK2, is a critical and conserved component in the regulatory program of the mitosis-to-meiosis switch
CLK1 (show CDK11B Proteins) Increases While CLK2 Decreases HIV-1 Gene Expression.
AKT (show AKT1 Proteins) activation controls cell survival to ionizing radiation by phosphorylating CLK2, revealing an important regulatory mechanism required for promoting cell survival.
Cdc2 (show CDK1 Proteins)-like kinases and DNA topoisomerase I (show TOP1 Proteins) regulate alternative splicing of tissue factor (show F3 Proteins) in human endothelial cells.
CLK2 is a regulatory component of diet-induced thermogenesis in brown adipose tissue.
Liver-specific Clk2 knockout mice fed a high-fat diet exhibit increased fasting levels of blood ketone bodies, reduced respiratory exchange ratio, and increased gene expression of fatty acid oxidation and ketogenic pathways.
Cdc2-like kinase 2 (Clk2) directly phosphorylates the SR domain on PGC-1alpha, resulting in repression of gluconeogenic gene expression and hepatic glucose output.
This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have been shown to interact with, and phosphorylate, serine- and arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. Note that this gene is distinct from TELO2 gene (GeneID:9894), which shares CLK2 and hCLK2 symbol aliases in common with this gene, but encodes a protein that is involved in telomere length regulation.
CDC-like kinase 2
, dual specificity protein kinase CLK2
, CLK kinase
, Clk2-Scamp3 protein