Browse our Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2) ELISA Kits

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Pleckstrin Homology-Like Domain, Family A, Member 2 ELISA Kits (PHLDA2)
On www.antibodies-online.com are 21 Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2) ELISA Kits from 3 different suppliers available. Additionally we are shipping Pleckstrin Homology-Like Domain, Family A, Member 2 Antibodies (84) and Pleckstrin Homology-Like Domain, Family A, Member 2 Proteins (21) and many more products for this protein. A total of 131 Pleckstrin Homology-Like Domain, Family A, Member 2 products are currently listed.
Synonyms:
BRW1C, BWR1C, HLDA2, Ipl, phlda2, Tssc3, zgc:110459
list all ELISA KIts Gene Name GeneID UniProt
PHLDA2 7262 Q53GA4
PHLDA2 22113 O08969
PHLDA2 293637  

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More ELISA Kits for Pleckstrin Homology-Like Domain, Family A, Member 2 Interaction Partners

Human Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2) interaction partners

  1. PHLDA2 plays an important role in the occurrence and development of pregnancy complications by promoting trophoblast apoptosis and suppressing cell invasion.

  2. TSSC3 was a prognostic marker in osteosarcoma.

  3. TSSC3 downregulation promotes the Epithelial to mesenchymal transition (EMT (show ITK ELISA Kits)) of osteosarcoma cells by regulating EMT (show ITK ELISA Kits) markers via a signal transduction pathway that involves Snail (show SNAI1 ELISA Kits), Wnt (show WNT2 ELISA Kits)-beta-catenin (show CTNNB1 ELISA Kits)/TCF (show HNF4A ELISA Kits), and GSK-3beta (show GSK3b ELISA Kits)

  4. Placental PHLDA2 expression was significantly 2.3 fold higher in reduced fetal movements pregnancies resulting in delivery of a growth restricted compared with a normal birth weight infant.

  5. PHLDA2 may promote the occurrence/development of preeclampsia by inhibiting proliferation/migration/invasion of trophoblasts.

  6. The gene expression pattern of CDKN1C (show CDKN1C ELISA Kits), H19 (show NCKAP1 ELISA Kits), IGF2, KCNQ1 (show KCNQ1 ELISA Kits) and PHLDA2 genes was evaluated using RT-PCR.

  7. results suggest upregulated pleckstrin homology-like domain family A member 2 (PHLDA2) in placenta of monozygotic twins may be associated with the pathogenesis of singleton intrauterine growth restriction

  8. TSSC3 overexpression suppressed osteosarcoma cell growth and increased apoptosis through caspase-3 (show CASP3 ELISA Kits) upregulation, suggesting that TSSC3 may play a pro-apoptosis role to maintain the normal balance of growth

  9. TSSC3 inhibits osteosarcoma tumorigenicity through reducing stemness and promoting apoptosis of tumor inducing cells

  10. A luciferase reporter assay was used to identify in the PHLDA2 promoter a 15 bp repeat sequence variant that significantly reduces PHLDA2-promoter efficiency. Maternal inheritance of the variant resulted in a significant increase in birth weight.

Mouse (Murine) Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2) interaction partners

  1. Phlda2 manipulates the placenta's demands for maternal resources, a process that must be tightly regulated by epigenetic marks to ensure optimal foetal growth.

  2. data support a direct role for elevated Phlda2 in limiting fetal growth but also suggest that growth restriction only manifests when there is limited placental reserve

  3. TSSC3 plays an important role in the differentiation from trophoblast stem cell to trophoblast progenitors and/or labyrinth trophoblasts through the TSSC3/PI3K/AKT (show AKT1 ELISA Kits)/MASH2 (show ASCL2 ELISA Kits) signaling pathway.

  4. Phlda2 gene is imprinted, with preferential expression from the maternal allele in placenta. It acts as a rheostat for placental growth, with overgrowth after gene deletion and growth retardation after loss of imprinting.

  5. A critical role for the imprinted Phlda2 gene in regulating glycogen (show GYS1 ELISA Kits) storage in the eutherian placenta is identified.

  6. Embryonic expression of Ipl in mice

  7. Ipl and Tih1 (show PHLDA3 ELISA Kits) are bona fide PH domain proteins, with broad specificity and moderate affinity for PIPs (show GPRASP1 ELISA Kits).

Pig (Porcine) Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2) interaction partners

  1. In the present study, a 259 base pair-specific sequence for IPL gene of the domestic pig was obtained and a novel SNP, a T/C transition, was identified in IPL exon 1. Variable imprinting status of this gene was observed in different developmental stages.

  2. Quantitative allelic sequencing supports maternal expression of PHLDA2 in fetal liver and placental tissues using an interbreed swine model.

Cow (Bovine) Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2) interaction partners

  1. imprinting status of four cattle genes (Tssc4 (show TSSC4 ELISA Kits),Nap1l4 (show NAP1L4 ELISA Kits), Phlda2 and Osbpl5 (show OSBPL5 ELISA Kits)) in seven types of tissues, were assessed in cattle.

  2. proper expression levels of the imprinted genes CDKN1C (show CDKN1C ELISA Kits) and PHLDA2 are critical for embryo development

  3. Pleckstrin homology-like domain family A member 2 (PHLDA2) gene is expressed across a range of cattle fetal tissues and stages. It provides the first evidence that PHLDA2 is a monoallelically expressed imprinted gene in cattle fetal tissues and placenta.

Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2) Antigen Profile

Antigen Summary

This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver.

Alternative names and synonyms associated with Pleckstrin Homology-Like Domain, Family A, Member 2 (PHLDA2)

  • pleckstrin homology-like domain, family A, member 2 (PHLDA2) Elisa Kit
  • Pleckstrin homology-like domain family A member 2 (phla2) Elisa Kit
  • pleckstrin homology-like domain, family A, member 2 (Phlda2) Elisa Kit
  • pleckstrin homology-like domain, family A, member 2 (phlda2) Elisa Kit
  • BRW1C Elisa Kit
  • BWR1C Elisa Kit
  • HLDA2 Elisa Kit
  • Ipl Elisa Kit
  • phlda2 Elisa Kit
  • Tssc3 Elisa Kit
  • zgc:110459 Elisa Kit

Protein level used designations for PHLDA2

pleckstrin homology-like domain, family A, member 2 , pleckstrin homology-like domain family A member 2 , Imprinted in placenta and liver protein , beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein , imprinted in placenta and liver protein , p17-BWR1C , p17-Beckwith-Wiedemann region 1 C , p17-Beckwith-Wiedemann region 1C , tumor suppressing subchromosomal transferable fragment cDNA 3 , tumor suppressing subtransferable candidate 3 , tumor-suppressing STF cDNA 3 protein , tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein , tumor-supressing STF cDNA 3 , protein 50C15 , tumor-suppressing subchromosomal transferable fragment 3

GENE ID SPECIES
743049 Pan troglodytes
100196497 Salmo salar
7262 Homo sapiens
22113 Mus musculus
293637 Rattus norvegicus
100719774 Cavia porcellus
100379631 Sus scrofa
618810 Bos taurus
423088 Gallus gallus
100036975 Xenopus laevis
553622 Danio rerio
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