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This result strongly suggests the possibility, for the first time, that isolated mutations in the short isoform of POU1F1 could be sufficient for induction of POU1F1-related combined pituitary hormone (show CGA ELISA Kits) deficiency.
High expression level of Pit-1 was significantly associated with poor overall survival of the patients (P=0.001) and Cox (show COX8A ELISA Kits) regression analysis indicated that Pit-1 might be a prognostic factor for breast cancer prognosis (HR=1.955, 95% CI=1.295-3.035, P=0.003).
The present study reports on screening of POU1F1, PROP1 (show PROP1 ELISA Kits), and HESX1 (show HESX1 ELISA Kits) in combined pituitary hormone (show CGA ELISA Kits) deficiency patients and the novel variations identified.
Data suggest that the first screening step diagnosis for pituitary adenoma was determined based upon immunohistochemical (IHC) scores for Pit-1, SF-1 (show NR5A1 ELISA Kits), and ACTH (show POMC ELISA Kits).
A missense POU1F1 mutation is associated with isolated growth hormone deficiency.
Data identify silent subtype 3 adenomas as aggressive monomorphous plurihormonal adenomas of Pit-1 lineage that may be associated with hyperthyroidism, acromegaly or galactorrhea and amenorrhea.
investigated the specific mutations in PROP1 (show PROP1 ELISA Kits), POU1F1, LHX3 (show LHX3 ELISA Kits), and HESX1 (show HESX1 ELISA Kits) genes in patients with combined pituitary hormone (show CGA ELISA Kits) deficiency (CPHD) in Turkey
Pit-1 regulates MMP-1 (show MMP1 ELISA Kits) and MMP-13 (show MMP13 ELISA Kits), and that inhibition of MMP-13 (show MMP13 ELISA Kits) blocked invasiveness to lung in Pit-1-overexpressed breast cancer cells.
These results suggest that the anti-PIT-1 antibody is not a cause but a marker of anti-PIT-1 antibody syndrome, in which cytotoxic T lymphocytes play a pivotal role in the pathogenesis.
New target genes of POU1F1 and downstream networks controlled by this factor.
The association between a MspI polymorphism in the porcine PIT-1 gene and backfat thickness in Belgian slaughter pigs was confirmed in a number of breeds. In crossbred progeny the MspI D allele could possibly be associated with a higher backfat thickness.
paper demonstrated that the genetic variation in intron 1 of the POU1F1 (Pit1) gene was high and these polymorphisms may provide useful makers for QTL analysis
The polymorphisms in the PIT1 gene of 103 pigs were examined and their frequencies in the maternal and paternal lineages of the Pietrain and Large White breeds, were compared.
The association of IGF1 (show IGF1 ELISA Kits), GH, and PIT1 markers with growth and reproductive traits were assessed.
homozygote genotypes of GH (LL) and beta-LG (AA) were superior compared to heterozygote genotypes, whereas, the heterozygote genotype of Pit-1 gene (AB) was desirable
results showed that GC genotype at 1178 locus of POU1F1 gene was advantageous for milk yield, milk protein (show CSN2 ELISA Kits) yield, and milk fat yield
Study of genetic variation in Yakutian cattle (Bos taurus L.) using the prolactin bPRL, growth hormone bGH, and transcription factor bPit-1 genes
No significant associations of the TaqI polymorphism of the bovine POU1F1 gene with body weight and average daily gain for different growth periods were observed.
The POU1F1 gene is associated with economically important traits in dairy cattle; an SNP in exon 3 of POU1F1 that changes a proline to a histidine was identified.
Results estimate the allele frequencies in polymorphic site of exon six of POU1F1 in three Iranian native and Holstein cattle, and show no significant association between POU1F1 polymorphism and milk production.
The association of the polymorphism of the POU1F1 gene with growth traits among Qinchuan, Limousin x Qinchuan, Angus x Qinchuan and Germany Yellow x Qinchuan crosses was analyzed.
may regulate growth hormone (show GH1 ELISA Kits) expression in somatotropes through the stimulation of POU1F1
We thereby analyzed multiple genomic publications related to POU1F1 and pituitary development in this study to identify genes and agents regulating POU1F1 lineage cell differentiation.
The maintenance conformation at the Pit-1 chromatin locus is dependent on autoregulation by Pit-1 protein.
Mice with hypomorphic expression of the sodium-phosphate cotransporter (show SLC17A3 ELISA Kits) PiT1/Slc20a1 (show SLC20A1 ELISA Kits) have an unexpected normal bone mineralization.
EKLF (show KLF1 ELISA Kits) increases PIT1 expression during RBC (show CACNA1C ELISA Kits) maturation by binding to its promoter in vivo.
Results suggested that Pit-1 w could be involved in the paracrine/autocrine system in mice and may be necessary for normal testicular function via its possible role in regulating PRL (show PRL ELISA Kits) expression in testicular germ cells.
Significant differences in gene expression were noted between each mutant and their normal littermates, as well as between Prop1 (show PROP1 ELISA Kits) and Pit1 mutants.
Data indicate that protective alleles of Mtap1a (show MAP1A ELISA Kits) are not sufficient to rescue DW/J-Pou1f1dw/dw mutant hearing.
Mouse Pit-1 w plays a role in spermatogenesis. This is the first report demonstrating the expression of Pit-1 variants arising from alternative promoters in mammals.
This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.
POU domain, class 1, transcription factor 1
, growth hormone factor 1
, pituitary-specific positive transcription factor 1
, pituitary-specific transcription factor 1
, POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)
, pituitary specific transcription factor
, pituitary-specific positive transcription factor 1 variant alpha
, pituitary specific transcription factor 1
, POU-domain transcriptional regulator
, pituitary growth factor
, Pituary specific transcription factor 1 (growth hormone factor 1)
, homeodomain protein for Growth Hormone (GH)
, pituitary-specific positive transcription factor 1 variant w
, pit-1/GHF-1 transcription factor
, pituitary specific transcription factor 1, related sequence 1