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ARHGAP24 may regulate pseudopod formation downstream of activated ARF6 (show ARF6 ELISA Kits) in MDA-MB-231 human breast carcinoma cells.
Study identified FilGAP as a negative regulator of lymphocyte polarization and migration and shows that FilGAP may suppress lamellae formation at the front of migrating lymphocyte.
Src (show SRC ELISA Kits) family tyrosine kinase (show TXK ELISA Kits) signaling may regulate FilGAP through association with RBM10 (show RBM10 ELISA Kits)
FilGAP may contribute to change in cell motility of B-lymphocytes and in addition, its expression appears to be useful for predicting the behavior of B-cell lymphoma, in particular follicular lymphoma.
study suggests that Arf6 (show ARF6 ELISA Kits) and phosphorylation of FilGAP may regulate FilGAP, and phosphorylation of Ser (show SIGLEC1 ELISA Kits)-402 may play a role in the regulation of cell spreading on fibronectin (show FN1 ELISA Kits)
Polymorphism rs346473 in the ARHGAP24 gene might be a part of the genetic variants.
FilGAP may function as a mediator of the regulation of Rac (show AKT1 ELISA Kits) by Arf6 (show ARF6 ELISA Kits).
Data indicate that phosphorylation of FilGAP by ROCK appears to promote amoeboid morphology.
Consistent with structural predictions, strain increases beta-integrin binding to FLNA (show FLNA ELISA Kits), whereas it causes FilGAP to dissociate from FLNA (show FLNA ELISA Kits), providing a direct and specific molecular basis for cellular mechanotransduction
sequencing of the ARHGAP24 gene in patients with focal segmental glomerulosclerosis (FSGS (show ACTN4 ELISA Kits)) identified a mutation that impaired its Rac1-GAP activity and was associated with disease in a family with FSGS (show ACTN4 ELISA Kits)
New function of p73, independent of p53 (show TP53 ELISA Kits), in the neurogenic architecture of the SVZ of rodent brain.
these results therefore highlight an unanticipated role for p53 (show TP53 ELISA Kits) family proteins in a regulatory network that integrates essential Wnt (show WNT2 ELISA Kits)-Tcf (show HNF4A ELISA Kits) and nodal-Smad (show SMAD1 ELISA Kits) inputs.
TAp73 (show TP73 ELISA Kits) as necessary and sufficient for basal body docking, axonemal extension, and motility during the differentiation of Motile multiciliated cell progenitors.
p73 drives multiciliogenesis, both through transcriptional activation of a master ciliogenesis transcription factor FoxJ1 (show FOXJ1 ELISA Kits) and through regulation of multiple genes central to ciliogenesis.
The p73 acts as a critical regulator of multiciliogenesis in its capacity as a sequence-specific transcription factor, through genomic binding and regulation of genes.
Data show that the Mdm4 (show MDM4 ELISA Kits)-p73 axis cannot override the dominant role of p53 (show TP53 ELISA Kits) in development and tumorigenesis and that Mdm4 (show MDM4 ELISA Kits) and p73 interaction during development and tumorigenesis suggests new insight into the role of p53 (show TP53 ELISA Kits) family members.
In vivo inhibition of both p63 (show CKAP4 ELISA Kits) and p73 in combination accelerates tumor regression and increases survival of p53 (show TP53 ELISA Kits)-deficient mice.
Results indicate that p73 regulates basal and starvation-induced fuel metabolism in the liver, a finding that is likely to be highly relevant for metabolism-associated disorders, such as diabetes and cancer.
MDM2 (show MDM2 ELISA Kits) mediates p73 ubiquitination
p73 is required for endothelial cell differentiation, migration and the formation of vascular networks regulating VEGF (show VEGFA ELISA Kits) and TGFbeta (show TGFB1 ELISA Kits) signaling
ARHGAPs, such as ARHGAP24, encode negative regulators of Rho GTPases (see ARHA\; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004
RAC1- and CDC42-specific GTPase-activating protein of 72 kDa
, filamin-A-associated RhoGAP
, rho GTPase-activating protein 24
, rho-type GTPase-activating protein 24
, rhoGAP of 73 kDa
, sarcoma antigen NY-SAR-88
, Down-regulated in nephrectomized rat kidney 2
, p53-like transcription factor
, p53-related protein
, tumor protein p73
, transformation related protein 73