Browse our DISC1 Proteins (DISC1)

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Disrupted in Schizophrenia 1 Proteins (DISC1)
On are 9 Disrupted in Schizophrenia 1 (DISC1) Proteins from 5 different suppliers available. Additionally we are shipping DISC1 Antibodies (186) and DISC1 Kits (3) and many more products for this protein. A total of 210 DISC1 products are currently listed.
C1orf136, DISC1, SCZD9
list all proteins Gene Name GeneID UniProt
DISC1 27185 Q9NRI5
DISC1 244667 Q811T9
DISC1 307940 Q810H6

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DISC1 Proteins (DISC1) by Origin

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More Proteins for DISC1 Interaction Partners

Zebrafish Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. A Disc1 peptide binds to GSK3beta, and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin-mediated Wnt signaling and inhibiting GSK3beta activity.

  2. Disc1 and nrg1 (show NRG1 Proteins) function in controlling development of oligodendrocytes and neurones from olig2 (show OLIG2 Proteins)-expressing precursor cells.

  3. Disc1 functions in the transcriptional repression of foxd3 (show FOXD3 Proteins) and sox10 (show SOX10 Proteins), thus mediating cranial neural crest cell migration and differentiation.

Human Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. Findings indicate that disrupted-in-schizophrenia 1 (DISC1) and close homolog of L1 (show CHL1 Proteins) may engage in physical and functional interaction in neural development, supporting the notion that DISC1 regulates neurite outgrowth with a receptor belonging to the neural cell adhesion molecules.

  2. DISC1 increased the risk for late-onset Alzheimer's disease in northern Han Chinese population.

  3. Findings suggest that synapse-associated protein of 97-kDa molecular weight and disrupted in schizophrenia 1 contribute to maintaining Wnt/beta-catenin signaling activity within a homeostatic range by regulating glycogen synthase kinase 3 beta phosphorylation.

  4. DISC1 has distinctly folded regions, which are bisected by mental illness-related mutations

  5. These results should contribute to reveal DISC1 physiological function and potential pathogenic role in severe mental illnesses

  6. This population-based case-control study was carried out to determine whether polymorphisms in DISC1 and NRG1 (show NRG1 Proteins) genes could be associated with schizophrenia in the Chinese population.

  7. This study demonstrated that the Increased density of DISC1-immunoreactive oligodendroglial cells in fronto-parietal white matter of patients with paranoid schizophrenia.

  8. The present findings, at least in part, provide some clues for further investigating the association of DISC1 variants with SCZ susceptibility

  9. DISC1 may be involved in sleep regulation

  10. Polymorphisms in DISC1 play a role in vulnerability to opioid dependence in a Polish sample.

Mouse (Murine) Disrupted in Schizophrenia 1 (DISC1) interaction partners

  1. Co-disruption of DISC1 and NRG1 (show NRG1 Proteins), indicative of epistasis, evoked an impairment in sociability and enhanced self-grooming, accompanied by changes in hypothalamic oxytocin/vasopressin (show AVP Proteins) gene expression in a mouse schizophrenia model.

  2. the 100P mutation in Disc1 prevents expression of parvalbumin (show PVALB Proteins) by a normally sized cohort of interneurons and altering Disc1 function in cortical excitatory neurons indirectly affects parvalbumin (show PVALB Proteins) expression by cortical interneurons, perhaps as a result of altered functional input from the excitatory neurons.

  3. mutant DISC1 diminished the capacity of astrocytes to support dendritic and synaptic maturation in co-cultured neurons

  4. abnormality in hippocampal activity at the goal zone during the task may underlie the learning deficit observed in the DISC1 mutant mice.

  5. Missense mutation in DISC1 C-terminal coiled-coil has GSK3beta signaling and sex-dependent behavioral effects in mice

  6. Systematic investigation suggests that DISC1 is present in several cellular compartments, including synapses, where it interacts with a wider molecular network to mediate cellular and synaptic function.

  7. Hypoxic preconditioning decreases NF-kappaB (show NFKB1 Proteins) activity via Disc1.

  8. Results indicate that DISC1 attenuates Abeta (show APP Proteins) generation and cognitive deficits of APP (show APP Proteins)/PS1 (show PSEN1 Proteins) transgenic mice through promoting lysosomal degradation of BACE1 (show BACE Proteins)

  9. These results suggest that alteration of CB1R (show CNR1 Proteins)-mediated signaling in DN-DISC1 mice may underlie susceptibility to detrimental effects of adolescent cannabis exposure on adult behaviors.

  10. These results uncover an unexpected role for DISC1 in normal beta-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition.

DISC1 Protein Profile

Protein Summary

This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1\;11)(q42.1\;q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with DISC1

  • disrupted in schizophrenia 1 (disc1)
  • disrupted in schizophrenia 1 (DISC1)
  • disrupted in schizophrenia 1 (Disc1)
  • C1orf136 protein
  • DISC1 protein
  • SCZD9 protein

Protein level used designations for DISC1

disrupted in schizophrenia 1 protein , disrupted in schizophrenia 1 , disrupted in schizophrenia 1 homolog

407621 Danio rerio
719086 Macaca mulatta
742093 Pan troglodytes
100060246 Equus caballus
488970 Canis lupus familiaris
613555 Bos taurus
100156849 Sus scrofa
100356059 Oryctolagus cuniculus
100580606 Nomascus leucogenys
27185 Homo sapiens
244667 Mus musculus
307940 Rattus norvegicus
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