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anti-Human DSCAM Antibodies:
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Human Polyclonal DSCAM Primary Antibody for ELISA, WB - ABIN188562
Li, Guan: The Down syndrome cell adhesion molecule (DSCAM) interacts with and activates Pak. in The Journal of biological chemistry 2004
Migrating cells utilize dscam to remodel the developing embryo
Dscam1, the role of which during heart development was previously unknown, is required for both normal migration of cardioblasts and luminal expansion.
Sema1a and Dscam1 might play essential roles in the Drosophila DA1 (show TPM2 Antibodies) ventral olfactory projection neurons morphogenesis.
Studies suggest that the somatic mutually alternative splicing within a single gene may offer a simplified way of expressing a large Dscam repertoire.
Protein production, crystallization and preliminary crystallographic analysis of the four N-terminal immunoglobulin domains of Dscam1 has been reported.
Dysregulated Dscam binds to Abl through its cytoplasmic domain to enlarge presynaptic arbors in the Drosophila fragile X (show FMR1 Antibodies) syndrome model.
As thousands of Dscam isoforms are needed for the self-avoidance of the neuron, we propose that an increase in self-binding affinity provides the basis for the successful evolution of the arthropod brain
Manipulation of the Dscam1 isoform pool in single neurons caused severe disruption of collateral formation of mechanosensory axons.
The data of this study suggested that Dscam1 is required cell autonomously for normal adult motoneuron dendrite growth in Drosophila.
Dscam1 splicing is probabilistic through the analysis of alternative exon 4 expression using splicing reporters; widespread probabilistic splicing supports a role for Dscam1 diversity in self-recognition throughout the developing nervous system.
The found uncover a function of Dscam in presynaptic size control and provide insights into how dysregulated Dscam may contribute to the pathogenesis of neurological disorders.
Our study did not repeatedly confirm the association of the rs2222973 or the rs11770843 SNP with adolescent idiopathic scoliosis in a Chinese Han population.
The most significant was DSCAM, a neurological gene expressed widely in the developing brain and in the amygdala and hippocampus of the adult brain.
DSCAM physically interacts with tubulin folding cofactor D (show TBCD Antibodies).
DSCAM as a Hirschsprung disease (HSCR (show EDNRB Antibodies)) susceptibility locus, both in Down syndrome and HSCR (show EDNRB Antibodies) isolated cases.
Down syndrome cell adhesion molecule interacts with PRKAG1 (show PRKAG1 Antibodies) subunit and plays an important role in netrin-1 (show NTN1 Antibodies) induced neurite outgrowth.
knockdown of DSCAM inhibits netrin-induced tyrosine phosphorylation of UNC5C (show Unc5c Antibodies) and Fyn (show FYN Antibodies) as well as the interaction of UNC5C (show Unc5c Antibodies) with Fyn (show FYN Antibodies). The double knockdown of both receptors abolishes the induction of Fyn (show FYN Antibodies) tyrosine phosphorylation by netrin-1 (show NTN1 Antibodies)
The specificity of Drosophila Dscam is due to complementarity of variable residues in epitope I.
Overall, our study found a significant association of IL-17RC (show IL17RC Antibodies) gene polymorphisms with AIS (show AR Antibodies) in a Chinese Han population, indicating IL-17RC (show IL17RC Antibodies) gene may be as a susceptibility gene for AIS (show AR Antibodies).
Dscam may be involved in the generation and development of intractable epilepsy.
functionally conserved with Drosophila Dscam[TM1 (show TPM2 Antibodies)] isoforms
Together, these results demonstrate that different cell types have different dependencies on the PDZ-interacting C-termini of DSCAM and DSCAML1 for function, indicating multiple intracellular molecular mechanisms are involved.
work presents the correlation between DSCAM gene overexpression and a dysregulation of the P21 (show D4S234E Antibodies)-activated kinases pathway.
DSCAM mutation induces dystonic hypertonia and a disruption of locomotor gaits.
DSCAM mutation reduces or abolishes spinal reflexes in both neonatal isolated spinal cords and adult mice.
Results suggest that down syndrome cell adhesion molecule collaborates with deleted in colorectal cancer (show DCC Antibodies) to regulate microtubule dynamics via direct binding to dynamic TUBB3 (show TUBB3 Antibodies) in Netrin-1 (show NTN1 Antibodies)-induced axon branching.
Our results indicate an important role of DSCAM and DSCAML1 in the development of cortical neural network.
DSCAM colocalizes in developmentally dynamic patterns with adhesion and synaptic proteins in the mouse retina.
The findings of this study are as follows: (1) DSCAM is sufficient to drive cell death (2) dendrite avoidance defects in the Dscam loss-of-function retina do not reflect a role for DSCAM, and necessary and sufficient to target neurites.
A novel splice isoform of Dscam causes defects in lamination of type 2 and type 6 cone bipolar cells in Dscam mutant mice.
DSCAM contributes to pyramidal neuron morphogenesis by regulating dendrite arborization and spine formation during cortical circuit development
This gene is a member of the immunoglobulin superfamily of cell adhesion molecules (Ig-CAMs), and is involved in human central and peripheral nervous system development. This gene is a candidate for Down syndrome and congenital heart disease (DSCHD). A gene encoding a similar Ig-CAM protein is located on chromosome 11. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Down syndrome cell adhesion molecule
, Down's syndrome cell adhesion molecule
, down syndrome cell adhesion molecule
, down syndrome cell-adhesion molecule
, drosophila down syndrome cell adhesion molecule
, drosophila down syndrome cell adhesion molecule 1
, down syndrome cell adhesion molecule-like
, human CHD2-52 down syndrome cell adhesion molecule
, Down syndrome cell adhesion molecule homolog