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identified two novel native phosphorylation sites in the C terminus of NaV1.5 (show SCN5A ELISA Kits) that impair FGF13-dependent regulation of channel inactivation and may contribute to CaMKIIdeltac-dependent arrhythmogenic disorders in failing hearts.
These data showed the diversity of the roles of the FGF13 N-termini in NaV1.5 (show SCN5A ELISA Kits) channel modulation and suggested the importance of isoform-specific regulation
the FGF13/Nav1.7 (show SCN9A ELISA Kits) complex is essential for sustaining the transmission of noxious heat signals
for PCa (show FLVCR1 ELISA Kits) patients after RP, FGF13 serves as a potential novel prognostic marker that improves prediction of BCR (show BCR ELISA Kits)-free survival, in particular if combined with other clinical parameters.
The findings of this study reveal a novel cause of this syndrome and underscore the powerful role of FGF13 in control of neuronal excitability.
X-chromosome deletions may be a cause of WS with larger deletions being lethal to males and that FGF13 mutations may be a cause of Wildervanck Syndrome (WS).
Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells
FGF13 has a role in hair follicle growth and in the hair cycle as shown in a family with X-linked congenital generalized hypertrichosis
These results implicate that FGF13 is a critical cardiac Na(+) channel modulator and Fgf13 knockout mice have increased arrhythmia susceptibility in the setting of Na(+) channel blockade.
FGF13 down-regulated Spry1 (show SPRY1 ELISA Kits) protein expression, activating the ERK1/2 (show MAPK1/3 ELISA Kits) pathway by phosphorylation and leading to C2C12 cell differentiation inhibition.
Fibroblast growth factor homologous factors (FGF11 (show FGF11 ELISA Kits)-14) modulate cardiac calcium channels.
FGF13 has a role in hair follicle growth and in the hair cycle
Genetic deletion of FGF13 in mice results in neuronal migration defects in both the neocortex and the hippocampus. FGF13-deficient mice also exhibit weakened learning and memory.
FGF-13 may play a role in regulating the function of cells in the bulge region and basal layer of the epidermis.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini.
, fibroblast growth factor 13
, Fibroblast growth factor 13
, fibroblast growth factor homologous factor 2