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Irrespective of subtype, Acute Lymphoblastic Leukemia with high levels of IGHM, IGLL1 and VPREB1 are arrested at the pre-B stage and correlate with good prognosis in high-risk pediatric B-cell precursor acute lymphoblastic leukemia.
Hhydrophobic residues from the lambda5-UR is crucial for the interaction with GAL1 (show LGALS1 ELISA Kits) and for pre-BCR (show BCR ELISA Kits) clustering.
Data show no autoantibody production was detectable in surrogate light chain (SLC) components VpreB/CD179a and lambda5/CD179b transgenic mice.
Mice triply deficient for VpreB2 show B cell developmental defects but functional allelic exclusion of the IgH locus.
Data demonstrate that the pre-B-cell receptor is essential for monoallelic silencing of VpreB and lambda5 at the large pre-BII (show CACNA1E ELISA Kits)-cell stage.
The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene.
Ig lambda chain V-1 region
, Ig light chain variable region
, immunoglobulin lambda-like polypeptide 1
, Immunoglobulin lambda-like polypeptide 1-like
, CD179 antigen-like family member B
, CD179b antigen
, Pre-B lymphocyte-specific protein-2
, ig lambda-5
, immunoglobulin omega polypeptide chain
, immunoglobulin-related 14.1 protein
, immunoglobulin-related protein 14.1
, immunoglobulin lambda chain 5
, lambda 5
, Lambda 5
, immunoglobulin omega chain