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Both CLU (show CLU Antibodies) and PLXNA4 have been genetically associated with Alzheimer disease (AD) risk and our data thus provide a direct relationship between two AD risk genes. Our data suggest that increasing the levels of PLXNA4 or targeting CLU (show CLU Antibodies)-PLXNA4 interactions may have therapeutic value in AD.
Data indicate that plexin A1 (show PLXNA1 Antibodies)-4 (PLXNA1 (show PLXNA1 Antibodies)-4) mediation of neuroanatomical traits can be detected using in vivo neuroimaging techniques.
There is a significant association between Alzheimer's disease risk and SNPs in PLXNA4.
Rare variants in PLXNA4 and Parkinson's disease.
Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF (show VEGFA Antibodies) and bFGF (show FGF2 Antibodies) signaling.
These findings suggest that by interacting with PlexA4, TrkA (show NTRK1 Antibodies) plays a crucial role in redirecting local Sema3A (show SEMA3A Antibodies) signaling to retrograde axonal transport, thereby regulating dendritic GluA2 (show GRIA2 Antibodies) localization and patterning.
Distinct cytoplasmic domains in Plexin-A4 mediate diverse responses to semaphorin 3A (show SEMA3A Antibodies) in developing mammalian neurons.
results suggest that Plexin-A4 is involved in the precise positioning of oligodendrocyte precursor cells in developing cerebral cortex.
null mutations in Sema6A (show SEMA6A Antibodies) or PlexinA4 (PlexA4) exhibit a pronounced defect in OPL (show ZIC1 Antibodies) stratification of horizontal cell axons without any apparent deficits in bipolar cell dendrite or photoreceptor axon targeting.
Findings suggest plexin-A4 and Sema3A (show SEMA3A Antibodies) as new intervention points for treating sepsis.
suggesting that a Semaphorin6A-Plexin-A4 cis (show CISH Antibodies) interaction serves as an inhibitory mechanism.
plexin-A4 was expressed in the developing nervous system with a pattern different to that of other members of the plexin-A subfamily (plexin-A1 (show PLXNA1 Antibodies), plexin-A2 (show Plxna2 Antibodies) and plexin-A3 (show PLXNA3 Antibodies))
PlexA4 expressed in oligodendrocyte precursor cells acts as a mediator of semaphorin signals
plexin-A4, as a component of the receptor complex for class III semaphorins, negatively regulates T cell-mediated immune responses
Involved in the development of primary sensory neurons especially in branching of the peripheral axons. Interacts with the SLIT2 signaling specifically to promote axonal branching of Rohon-Beard neurons and the trigeminal sensory ganglion neurons.
, plexin A4, A
, plexin A4
, putative plexin 2