Browse our anti-ROBO2 (ROBO2) Antibodies

Full name:
anti-Roundabout, Axon Guidance Receptor, Homolog 2 (Drosophila) Antibodies (ROBO2)
On www.antibodies-online.com are 79 Roundabout, Axon Guidance Receptor, Homolog 2 (Drosophila) (ROBO2) Antibodies from 19 different suppliers available. Additionally we are shipping ROBO2 Proteins (9) and ROBO2 Kits (1) and many more products for this protein. A total of 97 ROBO2 products are currently listed.
Synonyms:
2600013A04Rik, 9430089E08Rik, anon-EST:Liang-1.75, BB097918, CG5481, CG5574, CG14347, CG14348, clone 1.75, CT17326, D-robo2, D230004I22Rik, Dmel\\CG5481, dRobo-2, fus4, mKIAA1568, robo-2, robo2, Robo 2, sax3, unp1881
list all antibodies Gene Name GeneID UniProt
ROBO2 6092 Q9HCK4
ROBO2 84409  
ROBO2 268902  

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anti-Human ROBO2 Antibodies:

anti-Rat (Rattus) ROBO2 Antibodies:

anti-Mouse (Murine) ROBO2 Antibodies:

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Top referenced anti-ROBO2 Antibodies

  1. Human Monoclonal ROBO2 Primary Antibody for ELISA, WB - ABIN4948252 : Rose, Behm, Drgon, Johnson, Uhl: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. in Molecular medicine (Cambridge, Mass.) 2010 (PubMed)
    Show all 5 references for 4948252

  2. Human Monoclonal ROBO2 Primary Antibody for FACS, ICC - ABIN4900566 : Guijarro-Muñoz, Cuesta, Alvarez-Cienfuegos, Geng, Alvarez-Vallina, Sanz: The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis. in Experimental cell research 2012 (PubMed)
    Show all 3 references for 4900566

  3. Human Polyclonal ROBO2 Primary Antibody for ICC, IF - ABIN4350856 : Sanz-Pamplona, Berenguer, Cordero, Molleví, Crous-Bou, Sole, Paré-Brunet, Guino, Salazar, Santos, de Oca, Sanjuan, Rodriguez-Moranta, Moreno: Aberrant gene expression in mucosa adjacent to tumor reveals a molecular crosstalk in colon cancer. in Molecular cancer 2014 (PubMed)

  4. Cow (Bovine) Polyclonal ROBO2 Primary Antibody for WB - ABIN2782202 : Bertoli-Avella, Conte, Punzo, de Graaf, Lama, La Manna, Polito, Grassia, Nobili, Rambaldi, Oostra, Perrotta: ROBO2 gene variants are associated with familial vesicoureteral reflux. in Journal of the American Society of Nephrology : JASN 2008 (PubMed)

  5. Human Polyclonal ROBO2 Primary Antibody for ELISA, WB - ABIN334482 : Fujisawa, Wrana, Culotti: The slit receptor EVA-1 coactivates a SAX-3/Robo mediated guidance signal in C. elegans. in Science (New York, N.Y.) 2007 (PubMed)

  6. Human Polyclonal ROBO2 Primary Antibody for IHC, ELISA - ABIN1535320 : Kidd, Brose, Mitchell, Fetter, Tessier-Lavigne, Goodman, Tear: Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. in Cell 1998 (PubMed)

More Antibodies against ROBO2 Interaction Partners

Human Roundabout, Axon Guidance Receptor, Homolog 2 (Drosophila) (ROBO2) interaction partners

  1. human placental multipotent mesenchymal stromal cell express Slit2 (show SLIT3 Antibodies) and both Robo1 (show ROBO1 Antibodies) and Robo4 (show ROBO4 Antibodies) are present in human umbilical vein endothelial cells.

  2. ROBO2 variants were not found to be associated with nonsyndromic vesicoureteral reflux with or without renal hypoplasia/dysplasia, providing further evidence for genetic heterogeneity

  3. ROBO2 and RASSF2A gene methylations may be related to gastric tumorigenesis, and ROBO2 gene methylation is associated with sporadic gastric cancer.

  4. Overexpression of ROBO2 induces its tumor suppressive effects in Breast cancer

  5. ROBO2 somatic mutation is associated with myelodysplastic syndrome progression. Overexpression of ROBO2 produces anti-proliferative and pro-apoptotic effects in leukemia cells. This effect was lost in ROBO mutants and ROBO-SLIT2 signaling is impaired.

  6. Common variation near ROBO2 is associated with expressive vocabulary in infancy.

  7. Mutations of the SLIT2 (show SLIT3 Antibodies)-ROBO2 pathway genes SLIT2 (show SLIT3 Antibodies) and SRGAP1 (show SRGAP1 Antibodies) confer risk for congenital anomalies of the kidney and urinary tract

  8. Down-regulation of ROBO2 expression is associated with prostate cancers.

  9. Frameshift mutations of ROBO1 (show ROBO1 Antibodies) and ROBO2 genes and alteration of ROBO2 expression in gastric and colorectal cancers suggest that both genes might play roles in the pathogenesis of both cancers.

  10. The finding that a polymorphism associated with the ROBO2 gene, which is involved in neurodevelopment, confers risk for the common emotionally reactive, impulsive aspects of conduct disorder, independent of concurrent risk for psychopathy.

Fruit Fly (Drosophila melanogaster) Roundabout, Axon Guidance Receptor, Homolog 2 (Drosophila) (ROBO2) interaction partners

  1. repulsive Slit-Robo2-Ena signaling exerts an extrusive force downstream of JNK (show MAPK8 Antibodies) to eliminate scrib (show SCRIB Antibodies) cells from epithelia by disrupting E-cadherin (show CDH1 Antibodies).

  2. The authors describe a distinct mechanism to inhibit Robo1 repulsion and promote midline crossing, in which Roundabout2 (Robo2) binds to and prevents Robo1 signaling.

  3. a Robo2-mediated mechanism, independent of signaling, is essential to limiting Slit distribution and which might be relevant to the regulation of Slit-mediated short-range signaling in additional systems

  4. Data identify Robo2 and Robo3 (show ROBO3 Antibodies) as key effectors of Hb9 (show MNX1 Antibodies) in regulating nervous system development.

  5. Data show that Robo and Robo2 promote midline repulsion, while Robo2 and Robo3 (show ROBO3 Antibodies) specify the position of longitudinal axon pathways.

  6. Study found that lateral positioning does not rely on structural differences between the Robo1 (show ROBO1 Antibodies) and Robo2 receptors-neither in their ectodomain nor cytoplasmic domains instead expression differences alone can account for lateral pathway selection.

  7. At the CNS midline, Slit functions as a repellent for tracheal branches and this function is mediated primarily by Robo. Robo2 is necessary for the tracheal response to the attractive Slit signal and its function is antagonized by Robo.

  8. robo, robo2, and robo3 (show ROBO3 Antibodies) play a role in the guidance of sensory axons in the Drosophila embryo by both slit-dependent and slit-independent mechanisms.

  9. axon guidance molecules roundabout2 and roundabout3 (robo2/3) are necessary for serotonergic neuron differentiation

  10. midline-secreted Slit activates Robo/Robo2 signalling to control the migration of the vmd1a sensory precursor cells

Zebrafish Roundabout, Axon Guidance Receptor, Homolog 2 (Drosophila) (ROBO2) interaction partners

  1. Genetic analysis showed that Caspase-3 (show CASP3 Antibodies), Caspase-9 (show CASP9 Antibodies), and p38 MAPK (show MAPK14 Antibodies) interacted with Slit1a-Robo2 signaling.

  2. The N-terminal domain unique to Robo3a (show ROBO3 Antibodies).1 mediates blockade of Robo2 repulsive activity.

  3. Robo2-Slit and Dcc (show DCC Antibodies)-Netrin1 coordinate the axonal projection choices of neurons developing in the forebrain.

  4. These results reveal that subtype-specific activity of Robo2 regulates subcircuit morphogenesis in the trigeminal sensory system.

  5. Increased arborization in robo2 mutants was phenocopied by dominant-negative Robo2 expressed in single retinal ganglion cells and rescued by full-length Robo2, indicating that Robo2 acts cell-autonomously.

  6. Robo2 acted initially to split the tract of the postoptic commissure into discrete fascicles upon entering a broad domain of Slit1a expression in the ventrocaudal diencephalon.

Mouse (Murine) Roundabout, Axon Guidance Receptor, Homolog 2 (Drosophila) (ROBO2) interaction partners

  1. While Slit1 (show SLIT1 Antibodies) and Robo2 are only expressed in peripheral axons and their cell bodies, Slit2 (show SLIT2 Antibodies), Slit3 (show SLIT3 Antibodies) and Robo1 (show ROBO1 Antibodies) are also expressed in satellite cells of the dorsal root ganglion, Schwann cells and fibroblasts of peripheral nerves.

  2. Robo1 (show ROBO1 Antibodies)/2 regulate follicle atresia through manipulating granulosa cell apoptosis in mice

  3. Roundabout receptor (Robo) genes are expressed in pulmonary neuroendocrine cells (PNECs), a rare, innervated epithelial population. Robo inactivation in mouse lung results in an inability of PNECs to cluster into sensory organoids and triggers increased neuropeptide production upon exposure to air.

  4. Loss of Robo2 resulted in a failure of the normal separation of the mesenchyme from the Wolffian duct/ureteric epithelium.

  5. Mutations of the SLIT2 (show SLIT2 Antibodies)-ROBO2 pathway genes SLIT2 (show SLIT2 Antibodies) and SRGAP1 (show SRGAP1 Antibodies) confer risk for congenital anomalies of the kidney and urinary tract

  6. Slit2 (show SLIT2 Antibodies) signaling through Robo1 (show ROBO1 Antibodies) and Robo2 has a role in retinal neovascularization

  7. Mycbp2 (show MYCBP2 Antibodies) and Robo2 were found to cooperate within a genetic network that has profound effects on axon guidance

  8. Report role of Robo2 in development of the caval veins and pericardium.

  9. Inactivation of Robo 2 leads to mispositioning of the stomach in the thoracic instead of the abdominal cavity, which likely contributes to poor lung inflation and lethality at birth, reminiscent of congenital diaphragmatic hernia.

  10. Robo2 signaling acts as a negative regulator on nephrin (show NPHS1 Antibodies) to influence podocyte foot process architecture.

ROBO2 Antigen Profile

Antigen Summary

This gene belongs to the ROBO family, part of the immunoglobulin superfamily proteins that are highly conserved from fly to human. The encoded protein is a receptor for SLIT2, molecules known to function in axon guidance and cell migration. Defects in this gene are the cause of vesicoureteral reflux type 2. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Alternative names and synonyms associated with ROBO2

  • roundabout, axon guidance receptor, homolog 2 (Drosophila) (ROBO2) antibody
  • roundabout, axon guidance receptor, homolog 2 (Drosophila) (Robo2) antibody
  • roundabout homolog 2-like (LOC534842) antibody
  • roundabout, axon guidance receptor, homolog 2 (Drosophila) (LOC100221297) antibody
  • roundabout, axon guidance receptor, homolog 2 (Drosophila) (robo2) antibody
  • leak (lea) antibody
  • roundabout homolog 2 (robo2) antibody
  • roundabout homolog 2 (Drosophila) (Robo2) antibody
  • roundabout, axon guidance receptor, homolog 2 (ROBO2) antibody
  • Robo2 (LOC100125614) antibody
  • roundabout, axon guidance receptor, homolog 2 (robo2) antibody
  • 2600013A04Rik antibody
  • 9430089E08Rik antibody
  • anon-EST:Liang-1.75 antibody
  • BB097918 antibody
  • CG5481 antibody
  • CG5574 antibody
  • CG14347 antibody
  • CG14348 antibody
  • clone 1.75 antibody
  • CT17326 antibody
  • D-robo2 antibody
  • D230004I22Rik antibody
  • Dmel\\CG5481 antibody
  • dRobo-2 antibody
  • fus4 antibody
  • mKIAA1568 antibody
  • robo-2 antibody
  • robo2 antibody
  • Robo 2 antibody
  • sax3 antibody
  • unp1881 antibody

Protein level used designations for ROBO2

roundabout homolog 2 , roundabout 2 precursor , Roundabout2 protein , roundabout, axon guidance receptor, homolog 2 (Drosophila) , roundabout, axon guidance receptor, homolog 2 , roundabout homolog 2-like , CG5481-PA , CG5481-PB , Robo2 , Roundabout2 , SGP cluster fusion defects 4 , lea-PA , lea-PB , roundabout 2 , ast , astray , zmp:0000000549 , Robo 2 , roundabout-2

GENE ID SPECIES
6092 Homo sapiens
84409 Rattus norvegicus
395291 Gallus gallus
460517 Pan troglodytes
487691 Canis lupus familiaris
534842 Bos taurus
100221297 Taeniopygia guttata
100388667 Callithrix jacchus
100493913 Xenopus (Silurana) tropicalis
100545405 Meleagris gallopavo
100567276 Anolis carolinensis
44522 Drosophila melanogaster
60309 Danio rerio
268902 Mus musculus
460516 Pan troglodytes
100125614 Ovis aries
100462919 Xenopus laevis
100068957 Equus caballus
100739586 Sus scrofa
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