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Mouse (Murine) SEMA3A Protein expressed in Human Cells - ABIN2008081
Chadborn, Ahmed, Holt, Prinjha, Dunn, Jones, Eickholt: PTEN couples Sema3A signalling to growth cone collapse. in Journal of cell science 2006
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Serum level of Sema3A taken from diagnosed celiac without gluten-free diet was higher significantly than healthy controls.
Sema3A serum levels and the expression of sema3A on Tregs was significantly lower in patients with moderate to severe asthma when compared to healthy individuals.
Sema3a-Nrp2 (show NELL2 Proteins) signaling along an unrecognized pancreatic developmental axis constitutes a chemoattractant system essential for generating the hallmark morphogenetic properties of pancreatic islets.
EV-delivered Sema3A orchestrates loss of barrier integrity in glioblastoma
IL6 (show IL6 Proteins) underexpression is associated with Breast Cancer.
We also demonstrate that the effects of RET (show RET Proteins) and NRG1 (show NRG1 Proteins) are universal across European and Asian ancestries. In contrast, we detected a European-specific association of a low-frequency variant, rs80227144, in SEMA3. Conditional analyses on the lead SNPs revealed a secondary association signal, corresponding to an Asian-specific, low-frequency missense variant encoding RET (show RET Proteins) p.Asp489Asn
Semaphorin3A serum concentrations were similar in ankylosing spondylitis patients and controls and were not altered on treatment in anti-TNF (show TNF Proteins) agents.
The self-renewal ability abolished by Sema3a knockdown could not be recovered by exogenous addition of recombinant SEMA3A. In addition, the activity of mammalian target of rapamycin (show FRAP1 Proteins) complex 1 (mTORC1) and the expression of its substrate p70S6K1 (show RPS6KB1 Proteins) were also decreased. These results demonstrate that Sema3a is a potential therapeutic target in eradication of CSCs.
Study shows a significant reduction of the serum Sema3A level and its mRNA expression in peripheral blood mononuclear cells in patients with relapsing-remitting multiple sclerosis compared with normal individuals.
Sema3A expression on T and B regulatory lymphocytes is low in familial Mediterranean fever (show MEFV Proteins) patients during attack and in smoldering disease compared to the expression in remission and healthy controls.
Sema3a-Nrp2 (show NRP2 Proteins) signaling along an unrecognized pancreatic developmental axis constitutes a chemoattractant system essential for generating the hallmark morphogenetic properties of pancreatic islets.
These data suggest that both Nrp1 (show NRP1 Proteins) and Sema3a are expressed in the cochlea during time points when spiral ganglion cell begin to innervate the organ of Corti.
We show that PTP-3, a LAR (show PTPRF Proteins) homolog in Caenorhabditis elegans, participates in Sema2A-regulated axon guidance. PTPdelta, a member of vertebrate LAR (show PTPRF Proteins) class PTPs (show PTS Proteins), is involved in Sema3A-regulated cortical dendritic growth. In Sema3A signaling, PTPdelta activates Fyn (show FYN Proteins) and Src (show SRC Proteins) kinases by dephosphorylating their C-terminal Tyr (show TYR Proteins) residues.
Investigated the effects of BotoxA-induced paralysis on the sprouting capacity of neuromuscular junctions (NMJs) in the K108N-SEMA3A mutant, and observed no change in the differential neuronal plasticity found at NMJs on fast-fatigable or slow muscle fibers due to the presence of the SEMA3A mutant protein.
The aim was to elucidate whether ectopic muscles are a result of misguidance of myoblast precursors due to the loss of Sema3A-Npn-1 (show NRP1 Proteins) signaling.
These findings suggest that by interacting with PlexA4 (show PLXNA4 Proteins), TrkA (show NTRK1 Proteins) plays a crucial role in redirecting local Sema3A signaling to retrograde axonal transport, thereby regulating dendritic GluA2 (show GRIA2 Proteins) localization and patterning.
Findings indicate that Rho and ROCK knockout may improve the behavior of mice and prevent MPTP (show PTPN2 Proteins)-induced dopaminergic neurons damage by regulating Sema3A, PlexinA and NRP-1 (show NRP1 Proteins) in a mouse model of Parkinson's disease.
Sema3A signaling exerts its oncogenic effect by promoting an mTORC1-mediated metabolic shift from oxidative phosphorylation to aerobic glycolysis.
Semaphorin 3A (Sema3A) is a protein secreted during the development of the nervous system that acts as a cue for axon induction .
this paper shows that Nav1.7 (show SCN9A Proteins), by coupling with CRMP1 (show CRMP1 Proteins), mediates the axonal retrograde signaling of Sema3A in axonal guidance
This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease.
, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
, semaphorin 3A
, collapsin 1
, semaphorin D
, semaphorin III
, semaphorin L
, sema D
, sema III
, Semaphorin 3a
, sema domain, immunoglobulin domain (Ig), short basic domain, sec