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Serum levels of soluble SEMA4D were elevated in patients with ANCA-associated vasculitis. Cell-surface expression of SEMA4D was downregulated, a consequence of proteolytic cleavage of membrane SEMA4D. Soluble SEMA4D exerted pro-inflammatory effects on endothelial cells. Membranous SEMA4D on neutrophils bound to plexin B2 on endothelial cells, and this interaction decreased NET formation.
We identified a novel genome-wide significant African-specific locus for BMI (SEMA4D, rs80068415). A novel variant in SEMA4D was significantly associated with body mass index. Carriers of the C allele were 4.6 BMI units heavier than carriers of the T allele.
A critical pathogenic engagement of Semaphorin 4D produced by gamma delta T cells in the development of medication-related osteonecrosis of the jaw
Our results identified FGL2 (show FGL2 Proteins), GAL (show GAL Proteins), SEMA4D, SEMA7A (show SEMA7A Proteins), and IDO1 (show IDO1 Proteins) as new candidate genes that could be involved in MSCs-mediated immunomodulation. FGL2 (show FGL2 Proteins), GAL (show GAL Proteins), SEMA4D, SEMA7A (show SEMA7A Proteins), and IDO1 (show IDO1 Proteins) genes appeared to be differentially transcribed in the different MSC (show MSC Proteins) populations. Moreover, these genes were not similarly modulated following MSCs-exposure to inflammatory signals
Interferon-alpha (show IFNA Proteins)-induced CD100 expression on naive CD8 (show CD8A Proteins)(+) T cells enhances antiviral responses to hepatitis C infection through CD72 (show CD72 Proteins) signal transduction.
In this review, we summarized the current findings on neuroimmune Sema4A (show Sema4a Proteins) and Sema4D molecules in chronic inflammation underlying many diseases and discussed their positive or negative impacts on the implicated molecular and cellular processes
we have identified a novel reverse signaling pathway acting through Tiam1 (show TIAM1 Proteins) and Rac (show AKT1 Proteins) that promotes aggressive behavior in OSCC expressing S4D and PB1 (show SMR3A Proteins).
sema (show SEMA3B Proteins) 4D was the direct target of miR (show MLXIP Proteins)-214 and was negatively regulated by miR (show MLXIP Proteins)-214 in ovarian cancer cells
Tax (show CNTN2 Proteins) and semaphorin 4D released from lymphocytes infected with human lymphotropic virus type 1 and inhibit neurite growth in a neuron cell line.
This assay specifically and reproducibly measured cSEMA4D saturation and expression levels. Evaluation of the SEMA4D-specific PD markers were critical in determining the clinical saturation threshold of cSEMA4D by VX15/2503
our findings revealed for the first time that Sema4D positively regulated both the adaptive and innate immune responses in contact hypersensitivity
SEMA4D-/- neutrophils show impaired NET formation when in contact with endothelial cells.
Absence of Sema4D improves oligodendrocyte recovery after cerebral ischemia/reperfusion injury in mice
Sema4D-deficiency affected ischemia-induced microglial activation in morphology, iNOS (show NOS2 Proteins) expression, and proliferation, and this deficiency most likely resulted in moderation of cytotoxicity and locomotor behavioral abnormality after cerebral ischemia
The addition of recombinant Sema4D to Sema4D/ vaginal epithelial cells in culture significantly enhanced apoptosis of the vaginal epithelial cells.
Sema4D may be an essential apoptosis-inducing ligand that acts downstream of estrogen action in vaginal epithelium during pubertal tissue remodeling.
therapeutic effects via bone-targeting systems featuring interference of Sema4d are able to partly counteract alveolar bone loss caused by osteoporosis.
CD100-mediated signals are critical for effective activation of gammadelta IEL to produce growth factors, including KGF (show FGF7 Proteins)-1, that are required for healing of the colon epithelium during colitis.
Deletion of plexin-B1 (show PLXNB1 Proteins), the high affinity receptor for semaphorin 4D, significantly (one-way ANOVA; p < 0.001) reduced thrombus weight (- 40%) in oxidative venous thrombosis.
Data indicate neuroimmune semaphorin 4D (Sema4D) as an important regulator of Th2-driven lung pathophysiology and as a potential target for a combinatory disease immunotherapy.
Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system\; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA (By similarity).
, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D
, M-sema G
, sema J
, semaphorin H
, semaphorin-C-like 2
, semaphorin 4D