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SMAD Specific E3 Ubiquitin Protein Ligase 1 ELISA Kits (SMURF1)
On www.antibodies-online.com are 3 SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) ELISA Kits from 2 different suppliers available. Additionally we are shipping SMURF1 Antibodies (109) and SMURF1 Proteins (5) and many more products for this protein. A total of 127 SMURF1 products are currently listed.
Synonyms:
4930431E10Rik, mKIAA1625, RGD1309707
list all ELISA KIts Gene Name GeneID UniProt
SMURF1 57154 Q9HCE7
SMURF1 75788 Q9CUN6
Rat SMURF1 SMURF1 690516  

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Human SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) interaction partners

  1. Data suggest that SMURF1 is required for S phase progression; SMURF1 promotes ubiquitination-dependent degradation of WEE1 (show WEE1 ELISA Kits); these functions of SMURF1 appear to be linked and may be important in cell proliferation and tumorigenesis. (SMURF1 = SMAD specific E3 ubiquitin protein ligase 1; WEE1 (show WEE1 ELISA Kits) = wee 1 (show WEE1 ELISA Kits) homolog [S pombe] protein)

  2. Taken together, our study for the first time clarified that the E3 ligase Smurf1 regulates USP5 protein stability and USP5-mediated TNF-alpha production through the ubiquitin proteasome pathway.

  3. results reveal the regulatory circuit between RUNX2 (show RUNX2 ELISA Kits) and SMURF1 controls RUNX2 (show RUNX2 ELISA Kits) expression and regulates odntoblastic differentiation in hDPSCs.

  4. EGF (show EGF ELISA Kits)/Smurf1 inhibits Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits)-induced osteogenic differentiation and that Smurf1 downregulates Wnt/b-catenin signaling by enhancing proteasomal degradation of beta-catenin (show CTNNB1 ELISA Kits).

  5. a model that CD166 (show ALCAM ELISA Kits) regulates MCAM (show MCAM ELISA Kits) through a signaling flow from activation of PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) and c-Raf (show RAF1 ELISA Kits)/MEK (show MAP2K1 ELISA Kits)/ERK (show EPHB2 ELISA Kits) signaling to the inhibition of potential MCAM (show MCAM ELISA Kits) ubiquitin E3 ligases, betaTrCP (show BTRC ELISA Kits) and Smurf1.

  6. SND1 (show SND1 ELISA Kits) promoted expression of the E3 ubiquitin ligase Smurf1, leading to RhoA (show RHOA ELISA Kits) ubiquitination and degradation.

  7. NF-kappaB (show NFKB1 ELISA Kits) bind to the -411 to -420 region of the SMURF1 promoter and plays an essential role in the expression of SMURF1.

  8. Smurf1 determines cell apoptosis rates downstream of DNA damage-induced ATR/Chk1 signalling by promoting degradation of RhoB.

  9. The role of SMURF1 and inhibition of BMP signaling in maintaining a CSC-like population was confirmed by the loss of a CD44 (show CD44 ELISA Kits)(high) expressing.

  10. Results suggest that elevated transcription and expression levels of ubiquitin ligase E3s WWP1, Smurf1 and Smurf2 (show SMURF2 ELISA Kits) genes may be the mechanisms of occurrence, development and metastasis of prostate cancer.

Mouse (Murine) SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) interaction partners

  1. Smurf1 regulates glucose metabolism and inhibits osteoblast differentiation. Smurf1 function requires the presence of serine 148 (S148) in Smurf1.

  2. Smurf1 mediates NGF (show NGFB ELISA Kits) signaling and ubiquitinates RhoA (show RHOA ELISA Kits) in growth cones, regulating the need for local translation and degradation.

  3. Smurf-mediated endocytosis of Patched1 (show PTCH1 ELISA Kits) is required in sonic hedgehog (show SHH ELISA Kits) signal reception

  4. Inhibition of rhBMP-2-induced ALP activity by intracellular delivery of SMURF1 in murine calvarial preosteoblast cells.

  5. Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin1 (show AXIN1 ELISA Kits) negatively regulates Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling.

  6. These results suggest that the JNK (show MAPK8 ELISA Kits)/AP-1 (show JUN ELISA Kits) and ERK (show EPHB2 ELISA Kits)/Runx2 (show RUNX2 ELISA Kits) signaling pathways mediate TNF-alpha (show TNF ELISA Kits)-dependent Smurf1 transcription.

  7. Smurf1 is a negative feedback regulator for IFN-gamma (show IFNG ELISA Kits) signaling by targeting STAT1 (show STAT1 ELISA Kits) for ubiquitination and proteasomal degradation.

  8. studies uncover a cell-cycle-independent function of Cdh1 (show CDH1 ELISA Kits), establishing Cdh1 (show CDH1 ELISA Kits) as an upstream component that governs Smurf1 activity

  9. ER stress induces Smurf1 degradation and WFS1 (show WFS1 ELISA Kits) up-regulation

  10. Smurf1 negatively regulates mesenchymal stem cell proliferation and differentiation by controlling JunB turnover through an ubiquitin-proteasome pathway.

Xenopus laevis SMAD Specific E3 Ubiquitin Protein Ligase 1 (SMURF1) interaction partners

  1. Data demonstrate that Smurf1 and Smurf2 (show SMURF2 ELISA Kits) have overlapping and distinct functionalities during early frog embryogenesis; collectively, they regulate ectodermal and mesodermal induction and patterning to ensure normal development of Xenopus embryos.

  2. In Xenopus embryos, the BMP pathway is a major physiological target of Smurf1. We propose that in normal development Smurf1 cooperates with secreted BMP antagonists to limit BMP signaling in dorsal ectoderm.

SMURF1 Antigen Profile

Antigen Summary

This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with SMURF1

  • SMAD specific E3 ubiquitin protein ligase 1 (SMURF1) Elisa Kit
  • SMAD specific E3 ubiquitin protein ligase 1 (LOC100220332) Elisa Kit
  • SMAD specific E3 ubiquitin protein ligase 1 (smurf1) Elisa Kit
  • SMAD specific E3 ubiquitin protein ligase 1 (Smurf1) Elisa Kit
  • 4930431E10Rik Elisa Kit
  • mKIAA1625 Elisa Kit
  • RGD1309707 Elisa Kit

Protein level used designations for SMURF1

Smad ubiquitination regulatory factor 1 , E3 ubiquitin-protein ligase SMURF1 , SMAD specific E3 ubiquitin protein ligase 1 , e3 ubiquitin-protein ligase SMURF1-like , E3 ubiquitin ligase SMURF1 , SMAD-specific E3 ubiquitin-protein ligase 1 , Smad-specific E3 ubiquitin ligase 1 , hSMURF1 , SMAD ubiquitination regulatory factor 1 , xSMURF1

GENE ID SPECIES
416487 Gallus gallus
513902 Bos taurus
608821 Canis lupus familiaris
100063241 Equus caballus
472670 Pan troglodytes
718616 Macaca mulatta
100081555 Ornithorhynchus anatinus
100220332 Taeniopygia guttata
100456599 Pongo abelii
100465094 Ailuropoda melanoleuca
100540915 Meleagris gallopavo
100556808 Anolis carolinensis
57154 Homo sapiens
75788 Mus musculus
100621443 Sus scrofa
690516 Rattus norvegicus
398131 Xenopus laevis
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