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Three CNGA1 (show CNGA1 Proteins) subunits and a single CNGB1 subunit form the rod cyclic nucleotide-gated ion channels.
Glutamic acid-rich proteins could provide the environment needed for protein interactions in the rim (show RBBP8 Proteins) region of optic discs.
Results suggest a novel role for glutamic acid-rich protein-2 as a regulator of spontaneous activation of rod photoreceptor phosphodiesterase, allowing rods to operate at the single photon detection limit.
Here, we present the first case of RP45 caused by an unequivocal homozygous nonsense variant of CNGB1 identified by run of homozygosity (ROH) analysis.
Helios (show ZNFN1A2 Proteins), and not FoxP3 (show FOXP3 Proteins), is the marker of activated Tregs expressing GARP/LAP, and FoxP3 (show FOXP3 Proteins)+Helios (show ZNFN1A2 Proteins)+ Tregs have more suppressive characteristics, compared with FoxP3 (show FOXP3 Proteins)+Helios (show ZNFN1A2 Proteins)- Tregs.
GARP2 expression in cones can be detrimental to cones. RDS (show PRPH2 Proteins)/GARP interactions remain under investigation but are critical for both OS structure and function.
Deletion of the cyclic nucleotide gated channel CNGB1 alters response waveform but leaves light adaptation intact in a transgenic model.
When expressed in a heterologous expression system the corresponding mutant full-length CNGB1a subunit was more susceptible to proteosomal degradation compared to the wild-type counterpart
we report targeting of cyclic nucleotide-gated channel(CNG (show CNGA1 Proteins)) to rod outer segment required interaction with ankyrin-G; ankyrin-G localized to rod outer segments, coimmunoprecipitated with CNG (show CNGA1 Proteins) channel & bound to C-terminal domain of channel beta1 subunit
olfactory sensory neurons in NCKX4 (show Slc24a4 Proteins)(-/-);CNGB1(DeltaCaM) mice displayed markedly reduced electro-olfactogram amplitude accompanied by alterations in other response attributes
Overexpression of rod photoreceptor glutamic acid rich protein 2 (GARP2) increases gain and slows recovery in mouse retina
Eliminating Cngb1 and reducing RDS (show PRPH2 Proteins) leads to additive defects in RDS (show PRPH2 Proteins) expression levels and rod electroretinogram (ERG (show ERG Proteins)) function, (e.g., Cngb1-/-/rds (show PRPH2 Proteins)+/- versus rds (show PRPH2 Proteins)+/- or Cngb1-/-) but not to additive defects in rod ultrastructure.
Peripherin-2 links CNGB1 to the light-detector rhodopsin in outer segments of rod photoreceptors.
These results confirm that rods are marginally functional in the absence of the beta-subunit (show POLG Proteins) and in addition show that CFF (show HCFC1 Proteins) (critical flicker frequency)may be a more sensitive measure of remaining functional cone vision
In Cngb1(-/-) x rd1 (show PDE6B Proteins) double mutants, cGMP levels are high, but rod photoreceptor viability and outer segment morphology are improved.
Deletion of the cyclic nucleotide gated channel CNGB1 alters response waveform but leaves light adaptation intact.
Our results show that CNGB1 is a crucial determinant of native cyclic nucleotide-gated channel targeting.
The role of CNGB1 in the function of the olfactory bulb and nucleotide-gated ion channel function is reported.
Ca2 (show CA2 Proteins)+/calmodulin-mediated CNG (show CNGA1 Proteins) channel fast desensitization is less important in regulating the sensitivity to recurring stimulation than previously thought and instead functions primarily to terminate olfactory sensory neuron responses
Subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit.
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
, cyclic nucleotide gated channel alpha 4
, cardiac hyperpolarization-activated current subunit 4
, cyclic nucleotide gated channel beta 1
, cyclic nucleotide gated channel alpha 3-like
, Cyclic nucleotide-gated cation channel alpha-4-like
, cyclic nucleotide-gated cation channel beta-1-like
, cyclic nucleotide-gated cation channel alpha-4-like
, CNG channel beta-1
, cyclic nucleotide-gated cation channel 4
, cyclic nucleotide-gated cation channel beta-1
, cyclic nucleotide-gated cation channel gamma
, cyclic nucleotide-gated cation channel modulatory subunit
, cyclic nucleotide-gated channel beta-1
, glutamic acid-rich protein
, glutamic-acid-rich protein
, cDNA sequence BC016201
, cyclic nucleotide-gated channel beta subunit 1
, 240 kDa protein of rod photoreceptor CNG-channel
, CNG channel 4