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Data support the notion that the Galpha (show SUCLG1 Proteins), but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 (show TRPC4 Proteins) activation and unveil new roles for RGS (show PITX2 Proteins) and AGS3 in fine-tuning TRPC4 (show TRPC4 Proteins) activities.
This study reviewed that Neurologic Phenotypes Associated with Mutations in RNASEH2C (show RNASEH2C Proteins) in patients with Aicardi-Goutieres Syndrome.
Activator of G-protein Signaling 3 is an important regulator of esophageal squamous cell carcinoma proliferation
Results confirmed that Ric-8A (show RIC8A Proteins) can directly bind to AGS3S but failed to facilitate Galpha (show SUCLG1 Proteins)(i)-induced suppression of adenylyl cyclase, suggesting that it may not serve as a guanine exchange factor for AGS3/Galpha (show SUCLG1 Proteins)(i/o)-GDP complex in a cellular environment.
RNase H2 complex is assembled in the cytosol and imported into the nucleus in an RNase H2B (show RNASEH2B Proteins)-dependent manner.
High GPSM1 gene methylation is associated with gastric tumor aggressiveness.
Data identified three new loci for type 2 diabetes with genome-wide significance: MIR129-LEP (show LEP Proteins), GPSM1 and SLC16A13 (show SLC16A13 Proteins).
Our data indicate that decreased expression of AGS3 is correlated with reduced levels of p-CREB (show CREB1 Proteins) in the apoptotic model. The negative role of AGS3 in cell apoptosis was further confirmed by knocking down AGS3.
these results indicate that GRK6 (show GRK6 Proteins) complexes with AGS3-Galphai2 (show GNAI2 Proteins) to regulate CXCR2 (show CXCR2 Proteins)-mediated leukocyte functions at different levels, including downstream effector activation, receptor trafficking, and expression at the cell membrane.
These results provide mechanistic insights into how reversible modulation of Galpha(i3) activity by AGS3 and GIV maintains the delicate equilibrium between promotion and inhibition of autophagy.
We conclude that LPS (show TLR4 Proteins) priming increases AGS3 levels, which enhances lysosomal function and increases the capacity of macrophages to eliminate intracellular pathogens.
level of basal autophagy, autophagic induction, autophagic flux, autophagic degradation and the anti-autophagic action in macrophages that lacked Galphai3 (show GNAI3 Proteins), AGS3, or RGS19 (show RGS19 Proteins); or had been treated with pertussis toxin, were similar to controls
AGS3 has a role in the regulation of G-protein signaling in the immune system
The present study demonstrates an important role for GPSM1 in controlling the dynamics of cyst progression in an orthologous mouse model of autosomal dominant polycystic kidney disease.
These data suggest that Gpsm1 acts through a novel receptor-independent mechanism to facilitate renal tubular epithelial cell proliferation and renal tubular regeneration.
AGS3 null mice exhibited a lean phenotype, reduced fat mass, and increased nocturnal energy expenditure.
The GPR (show ALDH18A1 Proteins) motif in this protein and other proteins is actually associated with activity as a GDI - guanine nucleotide dissociation inhibitor and not GTPase (show RACGAP1 Proteins) activator as initially suggested.
G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
RNase H1 small subunit
, RNase H2 subunit C
, aicardi-Goutieres syndrome 3 protein
, ribonuclease H2 subunit C
, ribonuclease HI subunit C
, G-protein-signaling modulator 1
, activator of G-protein signaling 3
, G-protein signaling modulator 1 (AGS3-like, C. elegans)
, G-protein signalling modulator 1 (AGS3-like, C. elegans)