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rd3 colocalizes and interacts with GC1 and GC2 in rod and cone photoreceptor cells of normal mice
guanylate cyclase 1 and guanylate cyclase 2 have roles in function of rod and cone photoreceptors
Results show GUCY2F gene was implicated in the pathogenesis of breast, lung, and pancreatic cancers and it may be useful targets for diagnostic and therapeutic intervention in selected patients.
Mutants of GC-activating protein 2 modulated ROS-GC2 in a manner different from their action on ROS-GC1 (show GUCY2D ELISA Kits) indicating that the Ca2 (show CA2 ELISA Kits)+ sensitivity of the Ca2 (show CA2 ELISA Kits)+ sensor is controlled by the mode of target-sensor interaction.
The findings define a new regulatory mechanism of the ROS-GC (show GUCY2D ELISA Kits) system that affects visual transduction and is likely to affect the course of retinal diseases caused by cGMP toxicity.
The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa.
, guanylate cyclase 2F, retinal
, guanylate cyclase F
, retinal guanylyl cyclase 2
, rod outer segment membrane guanylate cyclase 2
, guanylate cyclase 2D-like, membrane (retina-specific)