anti-Human Integrin beta 3 antibody for Biochemical Assay

Recommended Integrin beta 3 Antibody (supplied by: Log in to see )

Antigen
Integrin beta 3 (ITGB3) Antibodies
  • CD61
  • GP3A
  • INGRB3
  • BDPLT16
  • BDPLT2
  • GPIIIa
  • GT
  • INTB3
  • integrin
  • GPIIIA
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
  • integrin beta 3
  • integrin, beta 3
  • ITGB3
  • Itgb3
Reactivity
Human
602
249
203
28
27
25
24
19
16
13
6
5
4
4
4
3
2
2
2
2
2
2
1
1
1
1
Host
Mouse
377
238
52
29
28
4
1
Clonality
Monoclonal
Conjugate
This Integrin beta 3 antibody is conjugated to APC
78
54
27
22
18
13
13
13
13
10
9
8
8
8
7
7
7
7
6
6
6
5
2
2
2
2
2
2
2
Application
Biochemical Assay (BCA)
440
283
167
137
111
91
81
76
65
27
14
13
13
8
6
5
5
4
2
2
1
1
1
1
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Catalog No. ABIN2658696
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2658697 BCA APC Mouse IgG1 kappa Log in to see VI-PL2 3

General

Antigen Integrin beta 3 (ITGB3) Antibodies
Reactivity Human
(602), (249), (203), (28), (27), (25), (24), (19), (16), (13), (6), (5), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Host Mouse
(377), (238), (52), (29), (28), (4), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Integrin beta 3 antibody is conjugated to APC
(78), (54), (27), (22), (18), (13), (13), (13), (13), (10), (9), (8), (8), (8), (7), (7), (7), (7), (6), (6), (6), (5), (2), (2), (2), (2), (2), (2), (2)
Application Biochemical Assay (BCA)
(440), (283), (167), (137), (111), (91), (81), (76), (65), (27), (14), (13), (13), (8), (6), (5), (5), (4), (2), (2), (1), (1), (1), (1)
Pubmed 3 references available
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Product Details anti-Integrin beta 3 Antibody

Target Details Integrin beta 3 Application Details Handling References for anti-Integrin beta 3 antibody (ABIN2658696) Images
Cross-Reactivity Baboon, Rhesus Monkey, Cynomolgus
Purification The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.
Clone VI-PL2
Isotype IgG1 kappa

Target Details Integrin beta 3

Product Details anti-Integrin beta 3 Antibody Application Details Handling References for anti-Integrin beta 3 antibody (ABIN2658696) Images back to top
Antigen
Alternative Name CD61 (ITGB3 Antibody Abstract)
Background CD61, also known as integrin β3 and glycoprotein IIIa (gpIIIa), is a 90 kD type I integral transmembrane glycoprotein. It is a member of the integrin family, associating with platelet gpIIb (CD41) to form CD41/CD61 complex and with integrin αV (CD51) to form αV/β3 (CD51/CD61) integrin. CD41/CD61 is expressed on platelets and megakaryocytes, and plays a role in platelet activation and aggregation through interaction with fibrinogen, fibronectin, vWF, and other RGD-containing adhesion molecules. CD51/CD61 is expressed on platelets, osteoclasts, fibroblasts, macrophages, and some tumor cells involved in tumor metastasis, and in adenovirus infection through binding to RGD motif in extracellular matrix proteins.
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex

Application Details

Product Details anti-Integrin beta 3 Antibody Target Details Integrin beta 3 Handling References for anti-Integrin beta 3 antibody (ABIN2658696) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-Integrin beta 3 Antibody Target Details Integrin beta 3 Application Details References for anti-Integrin beta 3 antibody (ABIN2658696) Images back to top
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-Integrin beta 3 antibody (ABIN2658696)

Product Details anti-Integrin beta 3 Antibody Target Details Integrin beta 3 Application Details Handling Images back to top
Background publications

Roberts, Woods, Dale, Van Der Sluijs, Norman: "Protein kinase B/Akt acts via glycogen synthase kinase 3 to regulate recycling of alpha v beta 3 and alpha 5 beta 1 integrins." in: Molecular and cellular biology, Vol. 24, Issue 4, pp. 1505-15, 2004

Ciarlet, Crawford, Cheng, Blutt, Rice, Bergelson, Estes: "VLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment." in: Journal of virology, Vol. 76, Issue 3, pp. 1109-23, 2002

Davies, Warwick, Totty, Philp, Helfrich, Horton: "The osteoclast functional antigen, implicated in the regulation of bone resorption, is biochemically related to the vitronectin receptor." in: The Journal of cell biology, Vol. 109, Issue 4 Pt 1, pp. 1817-26, 1989

Images

Product Details anti-Integrin beta 3 Antibody Target Details Integrin beta 3 Application Details Handling References for anti-Integrin beta 3 antibody (ABIN2658696) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-Integrin beta 3 (ITGB3) antibody (APC) (ABIN2658696) anti-Integrin beta 3 (ITGB3) antibody (APC)