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Browse our LRRK2 (LRRK2) ELISA Kits

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Leucine-Rich Repeat Kinase 2 ELISA Kits (LRRK2)
On are 0 Leucine-Rich Repeat Kinase 2 (LRRK2) ELISA Kits from different suppliers available. A total of 0 LRRK2 products are currently listed.
4921513O20Rik, 9330188B09Rik, AURA17, AW561911, cI-46, D630001M17Rik, DARDARIN, Gm927, LRRK2, PARK8, RIPK7, ROCO2
list all ELISA KIts Gene Name GeneID UniProt
Human LRRK2 LRRK2 120892 Q5S007
Mouse LRRK2 LRRK2 66725 Q5S006
Rat LRRK2 LRRK2 300160  

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More ELISA Kits for LRRK2 Interaction Partners

Zebrafish Leucine-Rich Repeat Kinase 2 (LRRK2) interaction partners

  1. our similar early study and recent confirming experiments using the same reagents reported by Sheng et al. failed to reproduce the phenotype of the loss of dopaminergic neurons, although the mRNA of LRRK2 was molecularly disrupted

  2. results demonstrate that zLRRK2 is an ortholog of hLRRK2 and that the deletion of WD40 domain (show DCAF12L2 ELISA Kits) of zLRRK2 provides a disease model for PD

Human Leucine-Rich Repeat Kinase 2 (LRRK2) interaction partners

  1. DaT (show SLC6A3 ELISA Kits)-SPECT assessment depicts dopamine depletion among asymptomatic G2019S LRRK2 mutation carriers.

  2. This study demonstrated suggested that although olfactory function in LRRK2-PD patients is impaired, it is similar to that in Parkinson's Disease patients.

  3. This is the first report of LRRK2 I2020T and G2385R GTPase (show RACGAP1 ELISA Kits) activities and shows that most of the LRRK2 mutations that are pathogenic or a risk factor altered either kinase or GTPase (show RACGAP1 ELISA Kits) activity, suggesting that their physiological consequences are caused by altered enzyme activities.

  4. The present study demonstrates that MB expression of hLRRK2 in flies recapitulates the clinical features of the sleep disturbances in PD, and that melatonin attenuates hLRRK2-induced sleep disorders and synaptic dysfunction, suggesting the therapeutic potential of melatonin in PD patients carrying LRRK2 mutations.

  5. LRRK2 G2385R genotype may not be associated with cognitive dysfunction in Parkinson's disease.

  6. LRRK2 p.Gly2385Arg can explain most if not all of the PD association at rs1994090 in East Asians, but other nonsynonymous variants are independent.

  7. This study showed that LRRK2, PARK2 (show PARK2 ELISA Kits) and ATP13A2 (show ATP13A2 ELISA Kits) are under copy number variations influence in patient with Parkinson disease.

  8. decreased levels of miRNAs targeting LRRK2 might result in a gain of function for LRRK2, and by extension, loss of neuronal viability

  9. Pathogenic LRRK2 variants mapping to different functional domains increase phosphorylation of Rab (show HRB ELISA Kits) GTPases and this strongly decreases their affinity to regulatory proteins.

  10. Knockdown of either ULK1 (show ULK1 ELISA Kits) or DLP1 (show DNM1L ELISA Kits) expression with shRNAs suppresses LRRK2 G2019S expression-induced mitochondrial clearance, suggesting that LRRK2 G2019S expression induces mitochondrial fission through DLP1 (show DNM1L ELISA Kits) followed by mitophagy via an ULK1 (show ULK1 ELISA Kits) dependent pathway.

Mouse (Murine) Leucine-Rich Repeat Kinase 2 (LRRK2) interaction partners

  1. findings reveal a novel function of LRRK2 in regulating EPO (show EPO ELISA Kits) expression and imply a potentially novel relationship between PD genes and hematopoiesis.

  2. In the present study demonstrated that the up-regulation of HOTAIR and LRRK2 in the midbrain of PD mice induced by MPTP (show PTPN2 ELISA Kits).

  3. that mutant LRRK2 may impair synaptic vesicle dynamics via aberrant phosphorylation of N-ethylmaleimide sensitive fusion

  4. 14-3-3theta can regulate LRRK2 and reduce the toxicity of mutant LRRK2 through a reduction of kinase activity.

  5. LRRK2 has a role in microglia activation and sustainment of neuroinflammation.

  6. p21-activated kinase 6 (PAK6 (show PAK6 ELISA Kits)) as a novel interactor of leucine-rich repeat kinase 2 (LRRK2), a kinase involved in Parkinson's disease

  7. The data implicate gain of LRRK2 function in the pathogenesis of Parkinson disease

  8. LRRK2 regulates lysosome size, number and function in primary astrocytes and results show that expression of Parkinson's disease associated LRRK2 variants results in enlarged lysosomes

  9. Present results suggest that LRRK2 may play novel roles in both the immune system and the pathogenesis of various diseases.

  10. Selective expression of Parkinson's disease-related Leucine-rich repeat kinase 2 G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression

Pig (Porcine) Leucine-Rich Repeat Kinase 2 (LRRK2) interaction partners

  1. show that the LRRK2 sequence and expression patterns are conserved between pig and human

LRRK2 Antigen Profile

Antigen Summary

This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.

Alternative names and synonyms associated with LRRK2

  • leucine-rich repeat kinase 2 (lrrk2) Elisa Kit
  • leucine-rich repeat kinase 2 (LRRK2) Elisa Kit
  • leucine-rich repeat kinase 2 (Lrrk2) Elisa Kit
  • 4921513O20Rik Elisa Kit
  • 9330188B09Rik Elisa Kit
  • AURA17 Elisa Kit
  • AW561911 Elisa Kit
  • cI-46 Elisa Kit
  • D630001M17Rik Elisa Kit
  • DARDARIN Elisa Kit
  • Gm927 Elisa Kit
  • LRRK2 Elisa Kit
  • PARK8 Elisa Kit
  • RIPK7 Elisa Kit
  • ROCO2 Elisa Kit

Protein level used designations for LRRK2

leucine-rich repeat serine/threonine-protein kinase 2 , leucine-rich repeat kinase 2 , leucine-rich repeat serine/threonine-protein kinase 2-like , augmented in rheumatoid arthritis 17

559366 Danio rerio
745893 Pan troglodytes
100137384 Papio anubis
100145062 Xenopus (Silurana) tropicalis
100440374 Pongo abelii
100548936 Meleagris gallopavo
120892 Homo sapiens
66725 Mus musculus
300160 Rattus norvegicus
486608 Canis lupus familiaris
535652 Bos taurus
780403 Sus scrofa
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