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Prostaglandin D2 suppressed the lipolysis by repression of the cAMP-PKA-hormone-sensitive lipase (show LIPE ELISA Kits) axis through CRTH2 in adipocytes.
CRTH2 plays a pro-inflammatory role in TNBS-induced colitis. Eosinophils contribute to the severity of the inflammation, which is improved by a selective CRTH2 antagonist.
Consistent with this, murine group 2 innate lymphoid cells expressed CRTH2, migrated toward PGD2 in vitro, and accumulated in the lung in response to PGD2 in vivo
PGD2 (show PTGDS ELISA Kits) markedly augments disease activity through its ability to enhance the proinflammatory actions of macrophages and subsequent neutrophil activation.
Using various depression-related animal models, study demonstrated that the central CRTH2-mediated pathway is involved in depression
A deficiency in the prostaglandin D2 receptor CRTH2 exacerbates adjuvant-induced joint inflammation.
Prostaglandin D2 acts through the Dp2 (show TFDP2 ELISA Kits) receptor to influence male germ cell differentiation in the foetal mouse testis.
Our study provides the first evidence that central CRTH2 regulates specific emotional behaviors
Pyl upregulates CR3 (show ITGAM ELISA Kits) via CRTH2.
PGD2 (show PTGDS ELISA Kits) inhibits hair follicle regeneration through the Gpr44 receptor and imply that inhibition of PGD2 (show PTGDS ELISA Kits) production or Gpr44 signaling will promote skin regeneration.
CRTH2 plays a pro-inflammatory role in TNBS-induced colitis and Crohn's disease. Eosinophils contribute to the severity of the inflammation, which is improved by a selective CRTH2 antagonist. Serum levels of PGD2 (show PTGDS ELISA Kits) and Delta(12)-PGJ2 were increased in Crohn's disease patients as compared with control individuals.
this study shows that allergic rhinitis patients increased the amounts of VIP (show Vip ELISA Kits) and PGD2 (show PTGDS ELISA Kits) in their nasal secretions in the early phase reaction, however CRTH2 gene expression from leukocytes recovered in their nasal secretions was upregulated only during the late phase reaction
the CRTH2 expression on thyroid-infiltrating lymphocytes as well as on lymphocytes from peripheral blood was increased in Hashimoto's thyroiditis as compared to controls.
smaller proportion of group 2 innate lymphoid cells isolated from nondiseased human lung expressed CRTH2
Altered expression of chemoattractant CRTH2 on blood basophils and eosinophils in patients with chronic spontaneous urticaria
Hypermethylation of the selected markers (MAL, PRIMA1 (show PRIMA1 ELISA Kits), PTGDR (show PTGDR ELISA Kits) and SFRP1 (show SFRP1 ELISA Kits)) can result in reduced gene expression and may contribute to the formation of colorectal cancer.
Data indicate that in ulcerative colitis, DP2 (show APC ELISA Kits) receptor showed higher expression in neutrophils but lower in monocytes, and CRTH2 receptor was decreased in eosinophils, NK, and CD3 (show CD3 ELISA Kits)(+) T cells but not in monocytes and CD3 (show CD3 ELISA Kits)(+)/CD4 (show CD4 ELISA Kits)(+) T cells.
Low DP2 (show APC ELISA Kits) prostanoid receptor is associated with gastric cancer progression.
CRTh2 rs533116 was associated with allergic asthma in White people
CRTH2 is not expressed on human amniocytes or myocytes and plays no role in the mechanism of 15dPGJ2-mediated inhibition of NF-kappaB (show NFKB1 ELISA Kits)
This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.
G protein-coupled receptor 44
, G-protein coupled receptor
, chemoattractant receptor-homologous molecule expressed on Th2 cells
, G-protein coupled receptor 44
, PGD2 receptor
, chemoattractant receptor-homologous molecule expressed on TH2 cells
, prostaglandin D2 receptor 2
, prostaglandin D2 receptor CRTH2
, chemoattractant receptor homologous molecule expressed on T helper type 2 cells
, putative G-protein coupled receptor 44