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Mouse (Murine) ARNT ELISA Kit for Sandwich ELISA - ABIN426621
Rzemieniec, Litwa, Wnuk, Lason, Krzeptowski, Kajta: Selective Aryl Hydrocarbon Receptor Modulator 3,3'-Diindolylmethane Impairs AhR and ARNT Signaling and Protects Mouse Neuronal Cells Against Hypoxia. in Molecular neurobiology 2016
Morpholino experiments show that knockdown of ARNT1 offers protection from TCCD-induced cardiotoxicity.
Here the authors examined the crystal structures of multi-domain NPAS1 (show NPAS1 ELISA Kits)-ARNT and NPAS3 (show NPAS3 ELISA Kits)-ARNT-DNA complexes, discovering each to contain four putative ligand-binding pockets.
Findings reveal that certain blood cancers rely on ARNT isoform 1 to potentiate proliferation by antagonizing RelB (show RELB ELISA Kits) and p53 (show TP53 ELISA Kits)-dependent cell cycle arrest and apoptosis.
The structure clearly disclosed that AhRR (show CYP1A1 ELISA Kits) competitively represses AhR (show AHR ELISA Kits) binding to ARNT and target DNA and further suggested the existence of an AhRR (show CYP1A1 ELISA Kits)-ARNT-specific repression mechanism. This study provides a structural basis for understanding the mechanism by which AhRR (show CYP1A1 ELISA Kits) represses AhR (show AHR ELISA Kits)-mediated gene transcription.
Study showed that polymorphism rs2228099 of the ARNT gene could be a novel susceptibility gene to essential hypertension.
The results revealed a HIF-1alpha (show HIF1A ELISA Kits)-dependent mechanism leading to ARNT upregulation in hypoxia.
The protein levels of phosphorylated (p)Akt, Erk1/2, pErk1/2, HIF1alpha and HIF1beta were significantly increased by 5.89, 0.5, 0.59, 1.46 and 0.92fold, respectively, in the patients with PAH, compared with those in the controls group
Report quinone-mediated induction of cytochrome P450 1A1 (show CYP1A1 ELISA Kits) in HepG2 cells through increased interaction of aryl hydrocarbon receptor (show AHR ELISA Kits) with aryl hydrocarbon receptor nuclear translocator.
this study shows that ARNT is upregulated in skin from atopic dermatitis patients in China
Data suggest that activation of the AhR (show AHR ELISA Kits)/ARNT (aryl hydrocarbon receptor/aryl hydrocarbon receptor (show AHR ELISA Kits) nuclear translocator) signaling by AhR (show AHR ELISA Kits) ligands (environmental carcinogens TCDD/3MC/PCB (show PC ELISA Kits) used here) represents novel mechanism for regulating the expression of ADH1B (alcohol dehydrogenase 1B (show ADH1B ELISA Kits)) and other isoenzymes (ADH4 (show ADH4 ELISA Kits), ADH6 (show ADH6 ELISA Kits)) in hepatocytes.
Authors report here that not only HIF1alpha but also ARNT regulates VEGF expression in 3D cancer spheroids. Results suggest the utility of the in vitro 3D cancer spheroid model for investigating angiogenesis in cancerous tissues.
results provide convincing evidence that reduced hepatic ARNT can contribute to inappropriate hepatic glucose production and post-prandial dyslipidaemia
These promoters possess potential signature sequences for common as well as different transcription factors suggesting complex regulation of Arnt gene.
The only in vivo defects found in beta-Arnt mice were significant increases in the respiratory exchange ratio and in vivo carbohydrate oxidation, and a decrease in lipid oxidation
hepatocyte ARNT is not a requirement for initiation of liver fibrogenesis, but does regulate pro-fibrotic gene expression and macrophage accumulation.
HIF-1beta hepatocyte-specific knockout mice had less liver injury and steatosis in response to Gao-binge ethanol treatment.
Candidate gene analysis focused on Arnt as an influence on circadian regulation in the 'drinking in the dark' phenotype of alcohol consumption.
crystal structures for each of mouse HIF-2alpha (show EPAS1 ELISA Kits)-ARNT and HIF-1alpha (show HIF1A ELISA Kits)-ARNT heterodimers in states that include bound small molecules and their hypoxia response element
We determined that ARNT is essential for adult and fetal hematopoietic stem cell viability and homeostasis.
ARNT is a critical regulator of myocardial fatty acid metabolism and its deletion leads to cardiomyopathy and an increase in triglyceride accumulation through PPARA (show PPARA ELISA Kits).
This study demonstrates for the first time the requirement of HIF1 for FSH (show BRD2 ELISA Kits)-regulated Vegfa (show VEGFA ELISA Kits) expression in vivo and that HIF1 acts via a single hypoxia response element in the Vegfa (show VEGFA ELISA Kits) promoter to exert its regulatory functions.
The aryl hydrocarbon (Ah) receptor is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the Ah receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound Ah receptor to xenobiotic responsive elements in the promoters of genes for these enzymes. This gene encodes a protein that forms a complex with the ligand-bound Ah receptor, and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1. A t(1\;12)(q21\;p13) translocation, which results in a TEL-ARNT fusion protein, is associated with acute myeloblastic leukemia. Alternative splicing results in multiple transcript variants.
aryl hydrocarbon receptor nuclear translocator
, aryl hydrocarbon receptor nuclear translocater
, ARNT protein
, HIF-1 beta
, dioxin receptor, nuclear translocator
, hypoxia-inducible factor 1 beta
, hypoxia-inducible factor 1-beta
, class E basic helix-loop-helix protein 2
, hypoxia-inducible factor 1, beta subunit
, Aryl hydrocarbon receptor nuclear translocator 1