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Human BMP6 ELISA Kit for Sandwich ELISA - ABIN414610
Ma?yszko, Koc-?órawska, Levin-Iaina, Ma?yszko, Ko?mi?ski, Kobus, My?liwiec: New parameters in iron metabolism and functional iron deficiency in patients on maintenance hemodialysis. in Polskie Archiwum Medycyny Wewn?trznej 2012
Show all 6 Pubmed References
Human BMP6 ELISA Kit for Sandwich ELISA - ABIN624952
Seamon, Wang, Cui, Keller, Dighe, Balian, Cui: Adenoviral Delivery of the VEGF and BMP-6 Genes to Rat Mesenchymal Stem Cells Potentiates Osteogenesis. in Bone marrow research 2013
Show all 8 Pubmed References
Plasma BMP6 was significantly increased in chronic heart failure patients.
Our results independently add further evidence to the role of BMP6 mutations as likely contributing factors to late-onset moderate IO unrelated to mutations in the established five HH genes.
Further investigation on clinical ESCC samples and non-tumorous adjacent tissue found that tumors with triple-positive BMP6, ALK2 (show ACRV1 ELISA Kits) and BMPRII (show BMPR2 ELISA Kits) had deeper growth than tumors with only BMP6 expression
study shows that patients with CRA had high expression of BMP6 and hepcidin (show HAMP ELISA Kits) and low expression of s-HJV (show HFE2 ELISA Kits). BMP6 was found to be negatively correlated with s-HJV (show HFE2 ELISA Kits); both regulate hepcidin (show HAMP ELISA Kits) expression and play important roles in the development of anemia.
the combined delivery of VEGF (show VEGFA ELISA Kits) and BMP-6 to the bone defect significantly enhanced bone repair through the enhancement of angiogenesis and the differentiation of endogenously recruited MSCs into the bone repair site.
BMP-6 upregulates somatostatin receptor actions, leading to reduction of GnRH-induced secretion of luteinizing hormone.
These observations suggest a novel role of BMP-6 in the inhibition of breast cancer metastasis by regulating secretion of MMPs(MMP-1 (show MMP1 ELISA Kits)) in the tumor microenvironment.
BMP-dependent physical interaction of VE-cadherin (show CDH5 ELISA Kits) with the BMP receptor (show BMPR1A ELISA Kits) ALK2 (show ACRV1 ELISA Kits) (BMPRI) and BMPRII (show BMPR2 ELISA Kits), resulting in stabilization of the BMP receptor (show BMPR1A ELISA Kits) complex and, thereby, the support of BMP6-Smad (show SMAD1 ELISA Kits) signaling.
BMP6 and oxidized low-density lipoprotein independently and synergistically induced osteogenic differentiation and mineralization in vascular endothelial cells.
Identify 3 heterozygous missense mutations in BMP6 in patients with unexplained iron overload. These mutations lead to loss of signaling to SMAD (show SMAD1 ELISA Kits) proteins and reduced hepcidin (show HAMP ELISA Kits) production.
Report temporal regulation of BMP6 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
The data demonstrate that endothelial cells are the predominant source of BMP6 in the liver and support a model in which endothelial cells BMP6 has paracrine actions on hepatocyte hemojuvelin (show HFE2 ELISA Kits) to regulate hepcidin (show HAMP ELISA Kits) transcription and maintain systemic iron homeostasis.
In summary, our data suggest that in obstructive nephropathy atrophy increases and fibrosis decreases with age and that this relates to increased BMP signaling, most likely due to higher BMP6 and lower CTGF (show CTGF ELISA Kits) expression.
Western blot analysis demonstrated that following BMP2 (show BMP2 ELISA Kits) and BMP7 (show BMP7 ELISA Kits) cotransfection of MC3T3E1 cells, the protein expression levels of BMP2 (show BMP2 ELISA Kits), BMP4 (show BMP4 ELISA Kits), BMP6, BMP7 (show BMP7 ELISA Kits), BMP9 (show GDF2 ELISA Kits) and Wnt3a (show WNT3A ELISA Kits) were increased compared with control cells
In Bmp6-/- mice, iron activated endogenous compensatory mechanisms of other BMPs that were not sufficient for preventing hemochromatosis (show HFE ELISA Kits) and bone loss.
BMP6 expression levels may have potential as predictive markers for the progression of non-alcoholic liver disease.
The expression of BMP6 in periodontal ligaments may contribute to interaction between the tooth and bone during the eruption and anchoring process.
BMP-6 secreted by prostate cancer cells induces IL-6 (show IL6 ELISA Kits) expression in macrophages; IL-6 (show IL6 ELISA Kits), in turn, stimulates the neuroendocrine differentiation of prostate cancer cells.
these data highlight a therapeutically innovative role for BMP6 by providing a means to enhance the amount of myogenic lineage derived brown fat.
These results are consistent with novel mechanisms for regulating Bmp6 and Hamp1 (show HAMP ELISA Kits) expression.
Prostate cancer-derived BMP-6 stimulates tumor-associated macrophages to produce IL-1a (show IL1A ELISA Kits) through a crosstalk between Smad1 (show SMAD1 ELISA Kits) and NF-kB1 (show NFKB1 ELISA Kits); IL-1a (show IL1A ELISA Kits), in turn, promotes angiogenesis and prostate cancer growth.
High BMP6 expression is associated with cystic ovarian disease.
BMP-6 mRNA is increased during transition from primordial to primary/secondary follicles in the goat ovaries.
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
bone morphogenetic protein 6
, VG-1-related protein
, Vg1-related sequence
, vegetal related growth factor (TGFB-related)
, vegetal-related (TGFB related) cytokine
, bone morphogenic protein 6