Browse our anti-CACNA1A (CACNA1A) Antibodies

Full name:
anti-Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit Antibodies (CACNA1A)
On www.antibodies-online.com are 32 Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A) Antibodies from 9 different suppliers available. Additionally we are shipping CACNA1A Kits (12) and CACNA1A Proteins (6) and many more products for this protein. A total of 50 CACNA1A products are currently listed.
Synonyms:
alpha1A, APCA, BccA1, BI, ca(v)2.1, Caca1a, CACH4, CACN3, cacna-a, cacna1a, Cacnl1a4, CAV2.1, Ccha1a, EA2, FHM, HPCA, la, leaner, MHP, MHP1, nmf352, rbA-1, rkr, rocker, SCA6, si:ch211-237k17.1, tg, tottering
list all antibodies Gene Name GeneID UniProt
CACNA1A 25398 P54282
CACNA1A 773 O00555
CACNA1A 12286 P97445

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Most Popular Reactivities for anti-CACNA1A (CACNA1A) Antibodies

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anti-Rat (Rattus) CACNA1A Antibodies:

anti-Human CACNA1A Antibodies:

anti-Mouse (Murine) CACNA1A Antibodies:

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Top referenced anti-CACNA1A Antibodies

  1. Human Polyclonal CACNA1A Primary Antibody for IHC, WB - ABIN350134 : Barry, Viglione, Kim, Froehner: Expression and antibody inhibition of P-type calcium channels in human small-cell lung carcinoma cells. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1995 (PubMed)
    Show all 5 references for 350134

  2. Rat (Rattus) Polyclonal CACNA1A Primary Antibody for WB - ABIN4620379 : Snutch, Leonard, Gilbert, Lester, Davidson: Rat brain expresses a heterogeneous family of calcium channels. in Proceedings of the National Academy of Sciences of the United States of America 1990 (PubMed)
    Show all 5 references for 4620379

  3. Human Polyclonal CACNA1A Primary Antibody for IHC, WB - ABIN1742172 : Scheuber, Miles, Poncer: Presynaptic Cav2.1 and Cav2.2 differentially influence release dynamics at hippocampal excitatory synapses. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 (PubMed)
    Show all 3 references for 1742172

  4. Rat (Rattus) Polyclonal CACNA1A Primary Antibody for WB - ABIN265030 : Starr, Prystay, Snutch: Primary structure of a calcium channel that is highly expressed in the rat cerebellum. in Proceedings of the National Academy of Sciences of the United States of America 1991 (PubMed)

More Antibodies against CACNA1A Interaction Partners

Zebrafish Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A) interaction partners

  1. The efficient activation of CaV2.1 channels during action potentials may contribute to the highly reliable transmission at zebrafish neuromuscular junctions.

Human Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A) interaction partners

  1. the novel R1673P allele of CACNA1A produces neurodegenerative phenotypes in flies and human, likely due to a toxic gain of function

  2. Whole exome sequencing technique confirmed, for the first time in the Polish population, a heterozygous T666M mutation (c.1997C>T; p.Thr666Met) in the CACNA1A gene in the proband, the proband's son and in several other family members. CONCLUSION: The presented report provides clinical and genetic insight into familial hemiplegic migraine 1 resulting from a mutation in the CACNA1A gene.

  3. CACNA1A and SPG7 are major ataxia genes.

  4. To assess the gene dosage effect in SCA6 homozygotes, study determined the effect of CACNA1A CAG repeat (show CELF3 Antibodies) length on the age-of-onset in heterozygotes, found that the total number of CAG repeats in both the normal and expanded alleles was inversely correlated with the age-of-onset in SCA6

  5. Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha (show RIMS1 Antibodies) for the CaV2.1 variant containing the region encoded by exons 44 and 47.

  6. Mutations in SLC1A2 (show SLC1A2 Antibodies) and CACNA1A Are Important Causes of Epileptic Encephalopathies

  7. Eye movement disorders are an early manifestation of CACNA1A mutations phenotype in children.

  8. The presence of SCN1A (show SCN1A Antibodies) mutations and absence of mutations in ATP1A2 (show ATP1A2 Antibodies) or CACNA1A suggest that the Polish patients represent FHM type 3.

  9. South American cohort did not confirm the effect of the four candidate loci as modifier of onset age: mithocondrial A10398G polymorphism and CAGn at RAI1 (show DOM3Z Antibodies), CACNA1A, ATXN3 (show ATXN3 Antibodies), and ATXN7 (show ATXN7 Antibodies) genes

  10. Cav2.1 dysfunction in episodic ataxia type 2 has unexpected effects on axon excitability.

Mouse (Murine) Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A) interaction partners

  1. These results demonstrate that a functional deficit in P/Q-type channels does not alter propulsive colonic motility. Myenteric neuron L-type Ca(2 (show CA2 Antibodies)+) channel function increases to compensate for loss of functional P/Q-type Ca(2 (show CA2 Antibodies)+) channels.

  2. Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha (show RIMS1 Antibodies) for the CaV2.1 variant containing the region encoded by exons 44 and 47.

  3. Cacna1a mutation plays a significant role in protein expression patterns in cerebellum of mutant mice.

  4. Our findings that BAG3 (show BAG3 Antibodies) is localized at the sarcolemma and t-tubules while modulating myocyte contraction and action potential duration through specific interaction with the beta1-adrenergic receptor and L-type Ca(2 (show CA2 Antibodies)+) channel provide novel insight into the role of BAG3 (show BAG3 Antibodies) in cardiomyopathies and increased arrhythmia risks in heart failure.

  5. Findings demonstrate that the mutant Cav2.1 channel exerts a protective effect against cryogenic brain injury in rolling Nagoya mice

  6. results indicate that regulation of CaV2.1 channels by Ca(2 (show CA2 Antibodies)+) sensor proteins is essential for normal synaptic plasticity at the neuromuscular junction and for muscle strength, endurance, and motor coordination in mice in vivo

  7. regulation of CaV2.1 channels by calcium sensor proteins is required for normal short-term plasticity

  8. Thus, GHSR1a differentially inhibits CaV2 (show CAV2 Antibodies) channels by Gi/o or Gq protein pathways depending on its mode of activation.

  9. Genetic ablation of Cacna1a in layer VI neurons produced Absence Epilepsy.

  10. CACNA1A regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis.

Cow (Bovine) Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A) interaction partners

  1. new information on the hypothalamic expression of alpha1A and alpha1D subunits during development in a mammal with a long gestation period and a large and convoluted brain.

  2. cloned the full-length alpha1A subunit

Rabbit Calcium Channel, Voltage-Dependent, P/Q Type, alpha 1A Subunit (CACNA1A) interaction partners

  1. Gem (show GEM Antibodies) contains two candidate inhibitory sites, each capable of producing full inhibition of P/Q-type Ca(2 (show CA2 Antibodies)+) channels.

  2. describe a CACNA1A mutation (A454T) that disturbs the functional interaction between SNAREs and the poreforming alpha1A subunit, resulting in mutant P/Q channels that are less efficiently coupled to secretion.

CACNA1A Antigen Profile

Antigen Summary

Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6.

Alternative names and synonyms associated with CACNA1A

  • calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (cacna1a) antibody
  • calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, a (cacna1aa) antibody
  • calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (CACNA1A) antibody
  • calcium channel, voltage-dependent, P/Q type, alpha 1A subunit (Cacna1a) antibody
  • P/Q-type voltage-gated calcium channel alpha1A subunit ChCaChA1A (LOC395892) antibody
  • alpha1A antibody
  • APCA antibody
  • BccA1 antibody
  • BI antibody
  • ca(v)2.1 antibody
  • Caca1a antibody
  • CACH4 antibody
  • CACN3 antibody
  • cacna-a antibody
  • cacna1a antibody
  • Cacnl1a4 antibody
  • CAV2.1 antibody
  • Ccha1a antibody
  • EA2 antibody
  • FHM antibody
  • HPCA antibody
  • la antibody
  • leaner antibody
  • MHP antibody
  • MHP1 antibody
  • nmf352 antibody
  • rbA-1 antibody
  • rkr antibody
  • rocker antibody
  • SCA6 antibody
  • si:ch211-237k17.1 antibody
  • tg antibody
  • tottering antibody

Protein level used designations for CACNA1A

calcium channel, voltage-dependent, P/Q type, alpha 1A subunit , voltage-dependent calcium ion channel alpha subunit , ZfCav2.1 , BI , RBA-I , brain calcium channel 1 , brain calcium channel I , brain class A , calcium channel alpha 1A , calcium channel, L type, alpha-1 polypeptide , calcium channel, voltage-dependent, alpha 1A subunit , voltage-dependent P/Q-type calcium channel subunit alpha-1A , voltage-gated calcium channel subunit alpha Cav2.1 , P/Q-type calcium channel alpha1A subunit , calcium channel, P/Q type, alpha 1A , calcium channel, alpha 1A subunit , voltage-gated calcium channel alpha 1A subunit , calcium channel BI-1 , calcium channel BI-2

GENE ID SPECIES
373828 Xenopus laevis
562059 Danio rerio
100021108 Monodelphis domestica
25398 Rattus norvegicus
773 Homo sapiens
12286 Mus musculus
282648 Bos taurus
100009265 Oryctolagus cuniculus
395892 Gallus gallus
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