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This study identified histone modification by SUMO as the first post-translational modification that stimulates intranucleosomal demethylation by the developmentally critical LSD1 (show KDM1A ELISA Kits)-CoREST complex.
results demonstrate that CoREST and LSD1 (show KDM1A ELISA Kits) downregulate the Notch (show NOTCH1 ELISA Kits) pathway in the developing cerebral cortex
ERalpha (show ESR1 ELISA Kits) engages not only LSD1 (show KDM1A ELISA Kits), but its partners of the CoREST corepressor complex and the molecular chaperone (show HSP90AA1 ELISA Kits) Hsp90 (show HSP90 ELISA Kits).
Expressions of REST and RCOR1 genes may downregulate SYN1 (show SYN1 ELISA Kits) expression in gliomas.
Rcor1 knock-out monocytes exhibited extensive self-renewal associated with hematopoietic stem cell expansion.
The results suggest that LSD1 (show KDM1A ELISA Kits)/CoREST interacts with extranucleosomal DNA when it productively engages its nucleosome substrate.
results suggest that LSD1 (show KDM1A ELISA Kits)-CoREST functions as an ergonomic clamp (show PDZK1 ELISA Kits) that induces the detachment of the H3 histone (show HIST1H3B ELISA Kits) tail from the nucleosomal DNA to make it available for capture by the enzyme active site.
Genomic deletions in RCOR1 are associated with a specific gene expression signature and with unfavorable clinical outcomes in diffuse large B-cell lymphoma patients.
Data show that miR (show MLXIP ELISA Kits)-22 specifically interacts with the 3' UTRs of the Rcor1, Rgs2 (show RGS2 ELISA Kits) and HDAC4 (show HDAC4 ELISA Kits) mRNAs.
Gfi-1B p32 (show C1QBP ELISA Kits) isoform binds to Gfi-1B target gene promoters and associates with the LSD1 (show KDM1A ELISA Kits)-CoREST repressor complex more efficiently than the major Gfi-1B p37 (show CCNH ELISA Kits) isoform
In mature erythroid cells, a strong upsurge in Rcor3 (show RCOR3 ELISA Kits) and a sharp decline in Rcor1 (show Rcor2 ELISA Kits) levels counteract LSD1 (show KDM1A ELISA Kits)/Rcor1 (show Rcor2 ELISA Kits)/2-mediated differentiation.
Rcor1 (show Rcor2 ELISA Kits) promotes erythropoiesis by repressing hematopoietic stem cells and/or progenitor genes, as well as the genes and signaling pathways that lead to myeloid cell fate.
This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor).
REST corepressor 1