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Through selective degradation of Clp subunits, AtCHIP could positively regulate homeostasis of Clp proteolytic subunits and maximize the production of functional chloroplasts. Similar results were obtained from transgenic tobacco plants.
we propose that CHIP and NBR1 (show NBR1 ELISA Kits) mediate two distinct but complementary anti-proteotoxic pathways and protein's propensity to aggregate under stress conditions is one of the critical factors for pathway selection of protein degradation
Hsc70-4 and CHIP were highly induced in ppi2 mutant plants, where they mediated the degradation of chloroplast-targeted precursors through the ubiquitin-26S proteasome (show Psmd4 ELISA Kits) system.
AtCHIP, an E3 ubiquitin liagase, functions upstream of protein phosphatase 2A in stress-responsive signal transduction pathways under conditions of low temperature or in the dark. [AtCHIP]
The interaction of CHIP with FtsH1 in vitro, in normal and in CHIP-over-expressing plants is reported.
The chaperone protein Hsp70 (show HSP70 ELISA Kits) was found to be important for CHIP and NUCB1 (show NUCB1 ELISA Kits) interaction as well as CHIP-mediated NUCB1 (show NUCB1 ELISA Kits) down-regulation.
CHIP is a negative regulator of RIPK1 (show RIPK1 ELISA Kits) and RIPK3 (show RIPK3 ELISA Kits), thus inhibiting necroptosis.
our study demonstrated that over-expressing miR (show MLXIP ELISA Kits)-21 in UCBMSCs could improve neovascularization in Critical limb ischemia (CLI (show CLU ELISA Kits)) through enhancing HIF-1alpha (show HIF1A ELISA Kits) activity by targeting CHIP, which may hold great therapeutic promise in treating CLI (show CLU ELISA Kits)
PABPN1 (show PABPN1 ELISA Kits) interacts with and is stabilized by heat shock protein 90 (show HSP90 ELISA Kits).
CHIP targets Osx (show SP7 ELISA Kits) for ubiquitination and degradation in osteoblasts after chronic exposure to TNF-alpha (show TNF ELISA Kits).
CHIP/TRAF3 (show TRAF3 ELISA Kits)/NIK (show MAP4K4 ELISA Kits) interactions recruit NIK (show MAP4K4 ELISA Kits) to E3 ligase complexes for ubiquitination and degradation, thus maintaining NIK (show MAP4K4 ELISA Kits) at low levels
Cbl-b, together with Stub1, ubiquitinate Foxp3 (show FOXP3 ELISA Kits), and regulate tTreg development.
CHIP regulates the levels of FMR1 (show FMR1 ELISA Kits) as an E3 ubiquitin ligase in phosphorylation-dependent manner, suggesting that CHIP regulates FMR1 (show FMR1 ELISA Kits)-mediated translational repression by regulating the levels of FMR1 (show FMR1 ELISA Kits).
The cardiac CHIP appears to play a role in regulating autophagy during the development of cardiac hypertrophy, possibly by its role in supporting Akt (show AKT1 ELISA Kits) signalling, induced by voluntary running in vivo.
Ebp1 (show NFKB1 ELISA Kits) p42 (show EPB42 ELISA Kits) isoform regulates the proteasomal degradation of the p85 (show ECM1 ELISA Kits) regulatory subunit of PI3K by recruiting a chaperone-E3 ligase complex HSP70 (show HSP70 ELISA Kits)/CHIP.
CHIP may serve as a promising prognostic biomarker for non-small cell lung cancer (NSCLC] patients and it may be involved in NSCLC angiogenesis through regulating VEGF (show VEGFA ELISA Kits) secretion and expression of VEGFR2 (show KDR ELISA Kits).
Cdk5 (show CDK5 ELISA Kits)-mediated phosphorylation of CHIP negatively regulates its neuroprotective function, thereby contributing to neuronal cell death progression following neurotoxic stimuli.
CHIP is a bona fide negative regulator of the RIPK1 (show RIPK1 ELISA Kits)-RIPK3 (show RIPK3 ELISA Kits) necrosome formation leading to desensitization of TNF (show TNF ELISA Kits)-mediated necroptosis
Protein-protein interactions modulate the docking-dependent E3-ubiquitin ligase activity of CHIP.
Data show that the E3 ubiquitin ligase CHIP interacts with protein arginine methyltransferase-5 (PRMT5 (show PRMT5 ELISA Kits)) both in vivo and in vitro.
These results indicate that CHIP decreases the Kv1.5 (show KCNA5 ELISA Kits) protein level and functional channel by facilitating its degradation in concert with chaperone Hsc70 (show HSPA8 ELISA Kits)
detailed and systematic investigation to characterize if there are significant differences in the CHIP in vitro ubiquitination of human Hsp70 (show HSP70 ELISA Kits) and Hsc70 (show HSPA8 ELISA Kits).
CHIP stabilizes amyloid precursor protein (show APP ELISA Kits) via proteasomal degradation and p53 (show TP53 ELISA Kits)-mediated trans-repression of BACE1 (show BACE ELISA Kits).
Our findings demonstrate for the first time that CHIP may be involved in RCC (show XRCC1 ELISA Kits) angiogenesis through regulating VEGF (show VEGFA ELISA Kits) secretion and expression of VEGFR2 (show KDR ELISA Kits).
results indicate that the post-endocytic ubiquitination of CFTR (show CFTR ELISA Kits) by CHIP is a critical step in the peripheral quality control of cell surface DeltaF508 CFTR (show CFTR ELISA Kits)
STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 2008
STIP1 homology and U-box containing protein 1
, STIP1 homology and U box-containing protein 1
, E3 ubiquitin-protein ligase CHIP
, carboxy terminus of Hsp70-interacting protein
, CLL-associated antigen KW-8
, antigen NY-CO-7
, heat shock protein A binding protein 2 (c-terminal)
, serologically defined colon cancer antigen 7
, STIP1 homology and U-Box containing protein 1