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Through selective degradation of Clp subunits, AtCHIP could positively regulate homeostasis of Clp proteolytic subunits and maximize the production of functional chloroplasts. Similar results were obtained from transgenic tobacco plants.
we propose that CHIP and NBR1 (show NBR1 ELISA Kits) mediate two distinct but complementary anti-proteotoxic pathways and protein's propensity to aggregate under stress conditions is one of the critical factors for pathway selection of protein degradation
Hsc70-4 and CHIP were highly induced in ppi2 mutant plants, where they mediated the degradation of chloroplast-targeted precursors through the ubiquitin-26S proteasome (show Psmd4 ELISA Kits) system.
AtCHIP, an E3 ubiquitin liagase, functions upstream of protein phosphatase 2A in stress-responsive signal transduction pathways under conditions of low temperature or in the dark. [AtCHIP]
The interaction of CHIP with FtsH1 in vitro, in normal and in CHIP-over-expressing plants is reported.
Consistent with reduced transcription factor EB (TFEB) activity, accumulation of phosphorylated TFEB in STUB1-deficient cells resulted in reduced autophagy and reduced mitochondrial biogenesis. These studies reveal that the ubiquitin-proteasome pathway participates in regulating autophagy and lysosomal functions by regulating the activity of TFEB.
ACR (show ACR ELISA Kits) interacts with proteins that regulate the ubiquitin-proteasome system, predominantly with the E3 ubiquitin-protein ligases Stub1, which binds the NH2 terminus of the ACR (show ACR ELISA Kits), and CRL4(CRBN (show CRBN ELISA Kits)), which is formed by Cul4a (show CUL4A ELISA Kits)/b, Ddb1, and Crbn (show CRBN ELISA Kits), and interacts with the COOH terminus of the ACR (show ACR ELISA Kits) via Crbn (show CRBN ELISA Kits).
The chaperone protein Hsp70 (show HSP70 ELISA Kits) was found to be important for CHIP and NUCB1 (show NUCB1 ELISA Kits) interaction as well as CHIP-mediated NUCB1 (show NUCB1 ELISA Kits) down-regulation.
CHIP is a negative regulator of RIPK1 (show RIPK1 ELISA Kits) and RIPK3 (show RIPK3 ELISA Kits), thus inhibiting necroptosis.
our study demonstrated that over-expressing miR (show MLXIP ELISA Kits)-21 in UCBMSCs could improve neovascularization in Critical limb ischemia (CLI (show CLU ELISA Kits)) through enhancing HIF-1alpha (show HIF1A ELISA Kits) activity by targeting CHIP, which may hold great therapeutic promise in treating CLI (show CLU ELISA Kits)
PABPN1 (show PABPN1 ELISA Kits) interacts with and is stabilized by heat shock protein 90 (show HSP90 ELISA Kits).
CHIP targets Osx (show SP7 ELISA Kits) for ubiquitination and degradation in osteoblasts after chronic exposure to TNF-alpha (show TNF ELISA Kits).
CHIP/TRAF3 (show TRAF3 ELISA Kits)/NIK (show MAP4K4 ELISA Kits) interactions recruit NIK (show MAP4K4 ELISA Kits) to E3 ligase complexes for ubiquitination and degradation, thus maintaining NIK (show MAP4K4 ELISA Kits) at low levels
Cbl-b, together with Stub1, ubiquitinate Foxp3 (show FOXP3 ELISA Kits), and regulate tTreg development.
CHIP regulates the levels of FMR1 (show FMR1 ELISA Kits) as an E3 ubiquitin ligase in phosphorylation-dependent manner, suggesting that CHIP regulates FMR1 (show FMR1 ELISA Kits)-mediated translational repression by regulating the levels of FMR1 (show FMR1 ELISA Kits).
These findings provide clinical and imaging support for the notion that CHIP is a crucial converging point of manifold neurodegenerative processes, corresponding with its universal biological function in neurodegeneration and reveal the second STUB1 family with ataxia plus hypogonadism.
the CHIP/CLEC-2 (show CLEC1B ELISA Kits) axis may play an important role in the modulation of immune response.
these findings indicate that the stability of the DDIAS protein is regulated by CHIP/HSP70 (show HSP70 ELISA Kits)-mediated proteasomal degradation and that CHIP overexpression stimulates the apoptosis of lung cancer cells in response to DNA-damaging agents
Study reveals a mechanism that the Warburg effect is regulated by CHIP through its function as an E3 ligase, which mediates the degradation of PKM2 during tumor progression.
The E3 ubiquitin ligase STUB1 is a negative regulator of both RUNX1 (show RUNX1 ELISA Kits) and RUNX1 (show RUNX1 ELISA Kits)-RUNX1T1 (show RUNX1T1 ELISA Kits). Activation of STUB1 could be a promising therapeutic strategy for RUNX1 (show RUNX1 ELISA Kits)-RUNX1T1 (show RUNX1T1 ELISA Kits) leukemia.
Data show that carboxyl-terminus of Hsp70-interacting protein (CHIP) promotes polyubiquitination of transglutaminase 2 (TG2 (show TGM2 ELISA Kits)) and its subsequent proteasomal degradation.
we report the identification of an unconventional p14ARF degradation pathway induced by the chaperone HSP90 in association with the E3 ubiquitin ligase C-terminus of HSP70-interacting protein (CHIP).
C terminus of Hsc70-interacting protein (show ST13 ELISA Kits) (CHIP) selectively interacted with epidermal growth factor receptor (EGFR (show EGFR ELISA Kits)) mutants and simultaneously induced their ubiquitination and proteasomal degradation.
Study reveals an important function of CHIP-mediated proteolysis in insulin (show INS ELISA Kits) and IGF1 (show IGF1 ELISA Kits) signaling; upon proteotoxic stress conditions and during aging, CHIP is recruited toward disposal of misfolded proteins, reducing its capacity to degrade the INSR (show INSR ELISA Kits); identify a degradation pathway that controls the level of active DAF-2 (show INSR ELISA Kits)/INSR (show INSR ELISA Kits) in C. elegans, Drosophila and human cells.
STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 2008
STIP1 homology and U-box containing protein 1
, STIP1 homology and U box-containing protein 1
, E3 ubiquitin-protein ligase CHIP
, carboxy terminus of Hsp70-interacting protein
, CLL-associated antigen KW-8
, antigen NY-CO-7
, heat shock protein A binding protein 2 (c-terminal)
, serologically defined colon cancer antigen 7
, STIP1 homology and U-Box containing protein 1