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Blocking CD226 inhibited NK cell-mediated cytotoxicity of the GM-CSF (show CSF2 Proteins)-stimulated Flt3 ligand (show FLT3LG Proteins) conventional dendritic cells. The CD226(+)NKG2A (show KLRC1 Proteins)(-) subset of NK cells was better at targeting GM-CSF (show CSF2 Proteins)-stimulated Flt3 ligand (show FLT3LG Proteins) conventional dendritic cells. CD155 (show PVR Proteins), a known ligand for CD226, could also act as an inhibitor of NK cell-mediated lysis, as dendritic cells lacking CD155 (show PVR Proteins) were more sensitive to NK cell-mediated lysis.
inflammatory monocytes, together with NK cells, are essential in the early control of CMV through the DNAM-1-PVR (show PVRL2 Proteins) pathway.
Data show that CD155 (show PVR Proteins) protein/CD226 antigen mainly mediates the interaction between NK cells and leukemic cells in acute myeloid leukemia (show BCL11A Proteins). To investigate the interaction between leukemic cells
absence of either CD155 (show PVR Proteins) or CD226 in BALB/c mice causes a profound shift in the Natural Killer T-Cells subtype composition in thymus, expanding the frequency and numbers of iNKT1 cells at the expense of iNKT2 cells, as well as iNKT17 cells.
our results suggest a limited role for DNAM-1 in solid allograft rejection. Blocking DNAM-1 is not sufficient to prevent allograft rejection and might be relevant only in combination with additional inhibitors of costimulation.
we propose that expression of DNAM-1 on inflammatory monocytes are evolutionally conserved and act as an adhesion molecule (show NCAM1 Proteins) on blood inflammatory monocytes.
Data indicate that DNAM-1 (CD226) signaling was required to enhance cytotoxicity.
Regulatory T cells derived (show CD4 Proteins)from Cd226-deficient mice showed similarly reduced inhibitory activity, eventually resulting in an exacerbated disease course of experimental autoimmune encephalomyelitis.
CD226 limits spontaneous multiple myeloma development in Vk*MYC (show MYC Proteins) transgenic mice. This is mediated both by NK and CD8 (show CD8A Proteins)+ T cells through perforin (show PRF1 Proteins) and IFN-gamma (show IFNG Proteins) pathways. It also is needed for cyclophosphamide and bortezomib treatment effectiveness.
Findings suggest that TIGIT (show TIGIT Proteins) is a key checkpoint inhibitor of chronic antiviral and antitumor responses through impairing CD226 function when disrupting its homodimerization.
cumulative incidences of acute graft-versus-host disease in patients with high maximal serum levels of sDNAM-1 (>/=30 pM) in the 7 days before allogeneic hematopoietic stem cell transplantation were significantly higher than those in patients with low maximal serum levels of sDNAM-1 in the same period. Our data suggest sDNAM-1 is potentially a unique candidate as a predictive biomarker for the development of acute GVHD.
Our results support an important association of rs4810485 in CD40 (show CD40 Proteins) gene and rs763361 in CD226 gene polymorphism, combined effect of rs4810485 and rs763361 with increased risk of systemic lupus erythematosus.
our results support and explain the mechanism behind the recently reported finding that in EOC, NK-cell recognition and killing of tumor cells was mainly dependent on DNAM-1 signaling while the contribution of the NKG2D (show KLRK1 Proteins) receptor-ligand pathway was complementary and uncertain.
CD226 rs763361 polymorphism was significantly associated with susceptibility to T1D.
Age and CMV serostatus influence the expression of NKp30 (show NCR3 Proteins), NKp46 (show NCR1 Proteins) and DNAM-1 activating receptors on resting and IL-2 (show IL2 Proteins) activated natural killer cells.
DNAM-1 ligands CD112 (show PVRL2 Proteins) and CD155 (show PVR Proteins) as well as the NKG2D (show KLRK1 Proteins) ligands MICA (show MICA Proteins) and MICB (show MICB Proteins) were expressed on the hiPSC lines
The CD226 gene has been identified as novel association with JIA, and a SNP near CD28 (show CD28 Proteins) as a suggestive association.
Effector and regulatory CD4 (show CD4 Proteins)+ memory T cells of healthy individuals carrying the predisposing CD226 variant showed, in comparison to carriers of the protective variant, reduced surface expression of CD226 and impaired induction of CD226 after stimulation.
The present study provides evidence that regulation of the PVR/CD155 (show PVR Proteins) DNAM-1 ligand expression by nitric oxide may represent an additional immune-mediated mechanism and supports the anti-myeloma activity of nitric oxide donors.
This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation.
, CD226 molecule
, platelet and T cell activation antigen 1
, platelet and T-cell activation antigen 1
, DNAX accessory molecule 1
, DNAX accessory molecule-1
, T lineage-specific activation antigen 1 antigen
, adhesion glycoprotein