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Data suggest that killer cell lectin-like receptors NKR (show TACR3 ELISA Kits)-P1B:Clr-b (Klrb1 (show KLRB1 ELISA Kits):Clec2d) interactions may provide a model for human hematopoietic cell transplants.
Reductions of Clr-b may be involved in sensitizing poxvirus-infected cells to natural killer (NK) cells.
LLT1 and CD161 have roles in modulating immune responses to pathogens; and interferon-gamma (show IFNG ELISA Kits) contributes to modulate immune responses
cloning and characterization of a cognate ligand, Ocil, for the inhibitory NK receptors (NKR)-P1B and NKR-P1D. Ocil/Clr-b is displayed at high levels on nearly all hematopoietic cells, in a pattern that is similar to that of class I MHC molecules.
Data show that osteoclast inhibitory lectin (OCIL) binds a range of physiologically important glycosaminoglycans, and this property may modulate OCIL actions upon other cells.
Limited divergence of the BALB/c Nkrp1-Ocil/Clr region helps explain a longstanding confusion regarding the strain-specific NK1.1 alloantigen reactivity of mouse natural killer cells.
OCIL is a physiological negative regulator of bone.
PTHrp (show PTHLH ELISA Kits)(1-34) regulates OCIL expression in vitro through cAMP/PKA, Ca(2 (show CA2 ELISA Kits)+)/CaMK II (show CAMK2B ELISA Kits), and MAPK (show MAPK1 ELISA Kits) signaling pathways.
Identification of a novel family of genes, named Clr (show CALCR ELISA Kits), encoding C-type lectin-like molecules, which maps in the natural killer (NK) gene complex (NKC) on mouse Chromosome 6.
Mouse Nkrp1d and Nkrp1f bind specific C-type lectin-related (Clr (show CALCR ELISA Kits)) molecules. Nkrp1d mediated inhibition when recognizing Clrb, a molecule expressed in dendritic cells and macrophages. Nkrp1 and Clr (show CALCR ELISA Kits) are intertwined in a genetically conserved NKC region.
these data suggest that LLT1-CD161 (show KLRB1 ELISA Kits) interactions play a novel and important role in B cell maturation (show TNFRSF17 ELISA Kits) within the Germinal center in humans.
In RA joints, LLT1 is expressed by cells of the monocyte/macrophage lineage.
The hexamer of glycosylated LLT1 consists of three classical dimers. The hexameric packing may indicate a possible mode of interaction of C-type lectin (show MBL2 ELISA Kits)-like proteins in the glycosylated form.
One polymorphism in LLT1 was found to be associated with our Crohn's Disease population (P<0.034).Our Ulcerative Colitis cohort was not associated with the variation in LLT1 (P=0.33)
LLT1 and CD161 (show KLRB1 ELISA Kits) have roles in modulating immune responses to pathogens; and interferon-gamma (show IFNG ELISA Kits) contributes to modulate immune responses
Molecular basis for LLT1 protein recognition by human CD161 (show KLRB1 ELISA Kits) protein (NKRP1A/KLRB1 (show KLRB1 ELISA Kits)).
Data show that only CLEC2D isoform 1 (LLT1) is expressed on the cell surface.
LLT1 used Src (show SRC ELISA Kits)-PTK, p38 (show CRK ELISA Kits) and ERK (show EPHB2 ELISA Kits) signalling pathways, but not PKC, PI3K (show PIK3CA ELISA Kits) or calcineurin pathways, to increase production of IFN-gamma (show IFNG ELISA Kits) by human natural killer cells.
LLT1 induces Interferon (show IFNA ELISA Kits) Type II production by natural killer cells.
Data show that osteoclast inhibitory lectin (OCIL) binds a range of physiologically important glycosaminoglycans, and this property may modulate OCIL actions upon other cells [OCIL].
This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified for this gene.
osteoclast inhibitory lectin
, c-type lectin-like receptor
, C-type lectin domain family 2, member D
, C-type lectin domain family 2 member D
, C-type lectin-domain family 2 member D
, C-type lectin-related protein B
, lectin-like transmembrane protein
, C-type lectin related f
, C-type lectin superfamily 2, member D
, lectin-like NK cell receptor
, lectin-like transcript 1
, C-type lectin domain family 2 member D5