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anti-Mouse (Murine) H2-T23 Antibodies:
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Mouse (Murine) Monoclonal H2-T23 Primary Antibody for BR, FACS - ABIN1177269
Lo, Ong, Metcalf, Soloski: T cell responses to Gram-negative intracellular bacterial pathogens: a role for CD8+ T cells in immunity to Salmonella infection and the involvement of MHC class Ib molecules. in Journal of immunology (Baltimore, Md. : 1950) 1999
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Mouse (Murine) Monoclonal H2-T23 Primary Antibody for FACS - ABIN2689887
Noble, Zhao, Cantor: Suppression of immune responses by CD8 cells. II. Qa-1 on activated B cells stimulates CD8 cell suppression of T helper 2 responses. in Journal of immunology (Baltimore, Md. : 1950) 1998
Show all 7 references for 2689887
In this study of C57BL mice, both H2-T23b and H2-T11b histocompatibility antigens are functional genes.
Qa-1 antigens are sensors for defects in peptide processing in the endoplasmic reticulum.
Qa-1(b) is critically involved in regulating IFN-gamma (show IFNG Antibodies) synthesis by NK cells in vivo through its interaction with CD94 (show KLRD1 Antibodies)/NKG2A (show KLRC1 Antibodies) inhibitory receptors[Qa-1(b)]
Qa-1 in complex with dominant peptide Qdm must be continuously replenished on target cells to inhibit recognition by CD94 (show KLRD1 Antibodies)/NKG2A (show KLRC1 Antibodies)+ natural killer (NK) cells at physiological temperature, even when bound to peptide with an ideal binding sequence.
Qa-1-NKG2A (show KLRC1 Antibodies) interaction protected activated CD4 (show CD4 Antibodies)+ T cells from lysis by a subset of NKG2A (show KLRC1 Antibodies)+ natural-killer cells
Stable expression of Qa1 on the surface of mature dendritic cells (DC) contributes to the protection of DC from natural killer cell-mediated lysis.
genetic disruption of the Qa-1-CD94 (show KLRD1 Antibodies)/NKG2A (show KLRC1 Antibodies) interaction unleashes robust CD8 (show CD8A Antibodies) Treg cell activity that completely abolishes development of experimental allergic encephalomyelitis
Involved in the presentation of foreign antigens to the immune system.
H-2 class I histocompatibility antigen, D-37 alpha chain
, MHC class I antigen Qa1
, MHC classIb Qa1