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In this study of C57BL mice, both H2-T23b and H2-T11b histocompatibility antigens are functional genes.
Qa-1 antigens are sensors for defects in peptide processing in the endoplasmic reticulum.
Qa-1(b) is critically involved in regulating IFN-gamma (show IFNG Proteins) synthesis by NK cells in vivo through its interaction with CD94 (show KLRD1 Proteins)/NKG2A (show KLRC1 Proteins) inhibitory receptors[Qa-1(b)]
Qa-1 in complex with dominant peptide Qdm must be continuously replenished on target cells to inhibit recognition by CD94 (show KLRD1 Proteins)/NKG2A (show KLRC1 Proteins)+ natural killer (NK) cells at physiological temperature, even when bound to peptide with an ideal binding sequence.
Qa-1-NKG2A (show KLRC1 Proteins) interaction protected activated CD4 (show CD4 Proteins)+ T cells from lysis by a subset of NKG2A (show KLRC1 Proteins)+ natural-killer cells
Stable expression of Qa1 on the surface of mature dendritic cells (DC) contributes to the protection of DC from natural killer cell-mediated lysis.
genetic disruption of the Qa-1-CD94 (show KLRD1 Proteins)/NKG2A (show KLRC1 Proteins) interaction unleashes robust CD8 (show CD8A Proteins) Treg cell activity that completely abolishes development of experimental allergic encephalomyelitis
Involved in the presentation of foreign antigens to the immune system.
H-2 class I histocompatibility antigen, D-37 alpha chain
, MHC class I antigen Qa1
, MHC classIb Qa1