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soluble HLA-Ib molecules HLA-G and HLA-E are present in BM plasma samples in physiological and pathological conditions, and their concentration correlated with stage disease in NB patients.
this study shows the high expression of HLA-E in actinic chelitis and in lip squamous cell carcinoma, which reflects the capacity that these pathologies have for evasion and progression
Our study reveals that HLA-E polymorphism is associated with nasopharyngeal cancer.
High expression of HLA-E is associated with non-small cell lung carcinoma.
The positive correlation has been found between the HLA-E*01:01/01:03 A>G polymorphism, plasma HLA-E level, and advanced fibrosis stages in chronic hepatitis B patients.
the promoter region of the HLA-E gene presents few and rare variable sites in Brazilian population sample.
HLA-E regulates NKG2C (show KLRC2 Proteins)+ natural killer cell function through presentation of a restricted peptide repertoire
HLA-E is capable of presenting a highly conserved peptide from HIV-1 capsid (AISPRTLNA) that is not recognized by NKG2A (show KLRC1 Proteins)/CD94 (show KLRD1 Proteins).
over-expression of HLA-E is associated with melanoma
Peptide-induced HLA-E expression in human PBMCs is dependent on peptide sequence and the HLA-E genotype.
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.
HLA class I histocompatibility antigen, E alpha chain
, HLA class I histocompatibility antigen, alpha chain E
, MHC HLA-E alpha-1
, MHC HLA-E alpha-2.1
, MHC class I antigen E
, lymphocyte antigen